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Re:Antibiotics damage the colonic mucus barrier in a microbi... by ggm on Wednesday September 11, 2024 @08:41PM (#41516587)
Nothing to remediation or repair in this. So, observational in mice, gut is gut and probably a good analogue for any non-ruminating mammal. But, how to mitigate, how to repair, what to do afterward is missing.

We need antibiotics. I don't want to go back into the world my parents lived in before they existed, I'd prefer to be in the world I was born into when they still had significant effect without wildcat over-use.

Would phage therapy avoid the problem?

Re:Antibiotics damage the colonic mucus barrier in a microbi... by woke_neolib on Wednesday September 11, 2024 @08:55PM (#41516638)
Two distinct classes of antibiotics (neomycin and vancomycin) seem to induce ER stress in colonic cells which decreases mucus production and increases risk of bacterial inflammation etc. The point is that there appears to be a direct effect on the host mouse physiology. There are other classes of antibiotics that do not have this effect, phage would likely be one of them (there is a theory that phage provided a persistent immunity by dwelling in the mucus).
Re:Antibiotics damage the colonic mucus barrier in a microbi... by Valgrim on Wednesday September 11, 2024 @08:49PM (#41516607)
I don't think this result reflects all antibiotic treatments:

"RESULTS Oral antibiotic treatment disrupts the colonic mucus barrier"

Intraveinous administration may or may not cause the same effect, or a similar effect. Maybe oral antibiotics is generally a bad idea because it disrupts the microbiome, but in other forms it's generally fine.

Re:Antibiotics damage the colonic mucus barrier in a microbi... by AmericanChopper on Wednesday September 11, 2024 @08:54PM (#41516635)
Overprescription of antibiotics and overuse of antibiotics in agriculture have both been known as public health risks for decades. So perhaps a little more prevention is the best cure could help address this.
Re:Antibiotics damage the colonic mucus barrier in a microbi... by Mistletoe on Wednesday September 11, 2024 @08:50PM (#41516611)
It’s not permanent. Just take your antibiotics and when you don’t need them your gut will go back to normal.
Re:Antibiotics damage the colonic mucus barrier in a microbi... by jb1991 on Wednesday September 11, 2024 @08:54PM (#41516632)
Source? This article doesn’t say anything about that.
Re:Antibiotics damage the colonic mucus barrier in a microbi... by theultdev on Thursday September 12, 2024 @12:45AM (#41517680)
They are living, they reproduce. Damaged ones die off.

That's why you're told to take yogurt/other fermented foods after taking antibiotics, to provide a reproductive environment for them to grow.

However it's still a risk you could kill off a whole species and lose their function, so probably best not to take antibiotics unless you really have to.

It's an easy analysis process though, you try to recover for a couple days, if you cannot and no virus is detected, you take antibiotics.

If it's a bacterial infection and it's spreading you have to take antibiotics, otherwise you die and all of your microbes die with you.

Re:Antibiotics damage the colonic mucus barrier in a microbi... by jb1991 on Thursday September 12, 2024 @04:58AM (#41518893)
The other comments in this thread about the recovery aren’t as optimistic as you are. It seems there is significant damage and it takes quite a long time to recover, if it does.
Re:Antibiotics damage the colonic mucus barrier in a microbi... by theultdev on Thursday September 12, 2024 @05:42AM (#41519123)
There's many variables, what kind of antibiotic, their biome before taking the antibiotics, what microbe species were killed and how many were harmed/killed, etc.

There's only a few total comments in this thread overall, I counted 2 anecdotes, not exactly a scientific consensus.

And people are more likely to comment when something goes bad than when something goes good *checks product feedback*

Re:Antibiotics damage the colonic mucus barrier in a microbi... by Choco31415 on Wednesday September 11, 2024 @08:55PM (#41516641)
For me that wasn't the case. I took antibiotics as directed by my dentist and it caused years worth of issues.
Re:Antibiotics damage the colonic mucus barrier in a microbi... by mikeodds on Thursday September 12, 2024 @06:25AM (#41519296)
Dairy intolerance?
Re:Antibiotics damage the colonic mucus barrier in a microbi... by Choco31415 on Thursday September 12, 2024 @10:41AM (#41521550)
To clarify, I was on the medication for six months.

It caused a gut condition that involved nausea, insomnia, and made it difficult to concentrate.

It was also causing me psychologically to feel as if the rug had been pulled out from under me - I didn't know what I was doing anymore.

Re:Antibiotics damage the colonic mucus barrier in a microbi... by AlexeyBelov on Saturday September 14, 2024 @02:26AM (#41537891)
How did you manage to go back to normalcy?
Re:Antibiotics damage the colonic mucus barrier in a microbi... by majkinetor on Thursday September 12, 2024 @03:30AM (#41518388)
It can take up to 2 years to recover your gut from AB. There are papers about it, cbb to find it now.
Re:Antibiotics damage the colonic mucus barrier in a microbi... by ipaddr on Friday September 13, 2024 @01:34AM (#41528267)
Not antibiotics are in the same class. If we could limit the fluoroquinolone class for none life threatening situations we can avoid some of the gravest issues.

Limiting antibiotics with livestock to only sick animals would require allowing them to live in decent conditions which would make everyone healthier.

Re:Antibiotics damage the colonic mucus barrier in a microbi... by itchyouch on Friday September 13, 2024 @04:24PM (#41534782)
This really needs to be broadcasted from the rooftops. Fluoroquinolones wreak massive havoc in their wake and should only be reserved for life threatening situations.