This really resonates with where my thinking has gone. While I always try to be guided by science, my default these days is much closer to "assume it isn't safe" than "assume it is". I've got multiple chronic medical conditions that me both more susceptible to getting to sick, and more likely to have complications/have a slow recovery if I do. So for instance, I keep (medical grade) gloves at home and wear them when using any sort of cleaning chemicals. My skin is fragile anyway, and almost any sort of solvent (that isn't water) is at least somewhat bad for you, either short or long term.