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Re:French authorities label Vitamin D as endocrine disruptor by drgoodvibe on Sunday November 19, 2023 @12:37PM (#38335197)
Everyone is built different. 4 years ago my bloodwork came back with an extremely low level of Vit D (so low the dr. Said they’ve never seen it that low. I live in Canada and work in an office so not a big surprise. But the severity and frequency of flu/colds lead me to investigate further including doing a genetic test. Turns out I am genetically predisposed to low vit d absorption. With dr supervision I began megadosing 4-5000 IUs daily. As of my latest bloodwork which was 3 weeks ago my vit. D is still just below average. What I have noticed is that the severity and frequency of my cold/flu is much lower than what it was pre-dosing. I know this is not placebo because often in the past if I got the flu it would lead to pneumonia. Since dosing I have not had a single case of it. My 2 cents N=1.
Re:French authorities label Vitamin D as endocrine disruptor by ronhav3 on Sunday November 19, 2023 @12:43PM (#38335301)
5000 is not 'megadosing' according to the latest research. It may well be on the low side of what is required.
Re:French authorities label Vitamin D as endocrine disruptor by mschwarz on Sunday November 19, 2023 @01:07PM (#38335636)
He said 4 x 5000 daily, which is considered a large dose
Re:French authorities label Vitamin D as endocrine disruptor by extra88 on Sunday November 19, 2023 @01:21PM (#38335831)
They didn't use an x, they used a hyphen. > I began megadosing 4-5000 IUs daily

That reads as "four to five thousand IUs."

Re:French authorities label Vitamin D as endocrine disruptor by _ink_ on Sunday November 19, 2023 @01:02PM (#38335565)
Where did you do the genetic test? Is there something else than 23andMe?
Re:French authorities label Vitamin D as endocrine disruptor by shepherdjerred on Sunday November 19, 2023 @01:08PM (#38335642)
> I know this is not placebo because often in the past if I got the flu it would lead to pneumonia. Since dosing I have not had a single case of it.

Just because something worked doesn't mean it wasn't a placebo.

Re:French authorities label Vitamin D as endocrine disruptor by pan69 on Sunday November 19, 2023 @02:13PM (#38336587)
Why would it be a placebo? Vit D can literally be measured, not?
Re:French authorities label Vitamin D as endocrine disruptor by HellzStormer on Sunday November 19, 2023 @03:32PM (#38337528)
When talking about placebo effect, it's the idea that the same thing could have happened taking a fake pill, just because the mind knows you are taking something that should have an effect.

Sure, the vitamin D in his blood may increase, but the anecdote of "it works" is about him getting sick less. And that could be a placebo effect and any sake pill would have had the same effect.

And the placebo effect can happen even when the person knows it's a fake pill.

Re:French authorities label Vitamin D as endocrine disruptor by shepherdjerred on Monday November 20, 2023 @02:23PM (#38353070)
Thank you for explaining that so well! I wasn't sure exactly how to phrase it.
Re:French authorities label Vitamin D as endocrine disruptor by jeanofthedead on Sunday November 19, 2023 @01:28PM (#38335943)
I don’t think we can call 4-5k IU’s of D3 a day ‘megadosing.’ megadosing is more like 50-100k at a time.
Re:French authorities label Vitamin D as endocrine disruptor by bilsbie on Sunday November 19, 2023 @01:31PM (#38335981)
Maybe consider a slightly higher dose. Also add magnesium and vitamin k to help the absorption.
Re:French authorities label Vitamin D as endocrine disruptor by bigtex on Sunday November 19, 2023 @02:11PM (#38336555)
There is a form of vitamin d called 25 hydroxy that the body will immediately absorb. Some doctors used it during Covid because in 24 hours with iv treatment they could get a patient into the proper range.
Re:French authorities label Vitamin D as endocrine disruptor by atombender on Sunday November 19, 2023 @02:37PM (#38336909)
You need about 1,000 IU per day to raise your serum levels by 25 nmol/L. The healthy level according to modern analysis is around 75-100 nmol/L.

What's important is that vitamin D is fat-soluble and will accumulate in your body. So if you do 5,000 IU/day for ever, your serum levels will likely just go up and up. 5,000 IU per day is not (as the other comments point out) anywhere a "megadose" — most people produce thousands of IU per hour when out in full sunlight — but it can eventually cause problems, including kidney stones and bone mineral density loss. (There's evidence that taking vitamin K2 together with the vitamin D helps maintain bone density.)

What's better is to do this for a while, then test your blood, then change the dose accordingly. Since the lag time is measured in weeks, it may take a while to find the right dose.

Re:French authorities label Vitamin D as endocrine disruptor by Projectiboga on Sunday November 19, 2023 @11:26PM (#38342241)
An interesting thing about the form from sunlight is that it can be stored at high doses safely and get converted into the active form as needed. And yes vitamin d supplements should be combined with vitamin K. D gets calcium into the blood, K gets it into your cells.
Re:French authorities label Vitamin D as endocrine disruptor by atombender on Monday November 20, 2023 @09:39AM (#38348910)
Do you have an authorative source on the vitamin K information? Not because I doubt it, I just want to read about it.
Re:French authorities label Vitamin D as endocrine disruptor by Projectiboga on Monday November 27, 2023 @01:02AM (#38428720)
No it was from a supplement trade publication.