But we’re not quite there yet.
At least all the audio cards should be doable as external boxes.
We've also got USB-C in the meantime, including a lot of USB-C displays.
So I think this is a case of "too early". The market looks very different today at how fast external communication is.
I'd say that MacStudio is really todays TrashCan. Much better timing, so much better success.
It is almost the reverse of TB1/TB2, when a mini-DisplayPort connector was used to negotiate TB.
I struggle to think of workflows that require macOS for this, given it has conceeded the high end of performance to others.
You can't match that speed with nvme. Samsung 990 Pro only gets 7.3 GB/s sequential read.
Only the the highest bandwidth cards, like certain NVMe SSD's, and network cards, need a full bandwidth slot.
Here are some examples, used mainly in pro audio/video/broadcast workflows:
RME MADI/AES cards: https://www.rme-audio.de/internal-cards.html
ProTools HDX cards: https://www.avid.com/products/pro-tools-hdx
BlackMagic DeckLink cards: https://www.blackmagicdesign.com/nl/products/decklink
UAD DSP cards: https://www.uaudio.com/uad-accelerators/uad-2-pcie.html
Plus 25/40/100G Ethernet, NVME SSD and Fibre Channel/SAN cards.