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Re:Researchers treat depression by reversing brain signals t... by endisneigh on Wednesday May 17, 2023 @11:53AM (#35977109)
disclaimer: I acknowledge depression as an illness and state of being.

that being said, if you take someone who is objectively "not depressed" and apply these same depression treatments, what would happen? some state of euphoria? heightened mood? happiness?

suppose that new state is now the normal state in which people are judged against. now, the before-mentioned person who was not depressed, may be considered depressed, relatively. so you now apply the same thought experiment again. clearly this can be recursively done infinitely...

such is an inflationary view. so my question really is around the cultural vs. biological construct of depression. what if it's ok to be depressed? this is not to say that we shouldn't be trying to "treat" it (and the symptoms), but I do wonder at what point do we say it's OK.

Re:Researchers treat depression by reversing brain signals t... by ebolyen on Wednesday May 17, 2023 @12:12PM (#35977425)
Instead of imagining that it works like a number line and then observing that you can use induction, you could measure outcomes: suicide, suicidal ideation, quality of life, etc.

That puts a pretty reasonable lower bound on what is or isn't depressed. It is absolutely an altered state of mind, and an information processing disorder.

For anyone who might feel like "it's ok to be depressed", this is not a normal thought, and there is no normal amount of suicidal ideation. Seek professional help or strong social support; just ask for help anywhere it might exist (go to an emergency room and just have a seat if you must). If you aren't depressed, these thoughts literally don't happen, as strange as that may sound if you are in the thick of it.

Re:Researchers treat depression by reversing brain signals t... by endisneigh on Wednesday May 17, 2023 @01:25PM (#35978500)
> , this is not a normal thought, and there is no normal amount of suicidal ideation

being depressed doesn't mean you have suicidal ideation, though.

Re:Researchers treat depression by reversing brain signals t... by jordan_curve on Wednesday May 17, 2023 @12:35PM (#35977760)
one common effect of SSRIs is that they can dull emotions. This is helpful and can be a positive effect if you are very depressed or get stuck in anxious spiraling.

If you're very stable and happy emotionally, then that dulling might be unpleasant.

Beyond that, while SSRIs tend to have fewer side effects and be more safe than many other classes of anti-depressants, even SSRIs have very noticeable side effects. They are very easy to stomach if they make a dramatic difference in your mood and quality of life, but if you were already mentally well the side effects will be more impactful than whatever benefits you might get.

Re:Researchers treat depression by reversing brain signals t... by tokyolights2 on Wednesday May 17, 2023 @01:40PM (#35978736)
Exactly this. I take a low level of SSRIs because I am an otherwise highly functioning person who has a tendency to get into severe anxious spirals that can last days on end and induce vomiting. I do all the things that a person should do to mitigate, including meditating, exercising, lots of friends, etc etc.

I know that my medication dulls my most intense emotions, but that is the point. It is slightly sad knowing that I don't experience the highest highs that I used to, but it is completely worth it to stop experiencing the lowest lows that were completely debilitating. I would stop taking them immediately if I could be assured that I wouldn't fall back into physically debilitating anxiety.

Re:Researchers treat depression by reversing brain signals t... by throitallaway on Wednesday May 17, 2023 @02:32PM (#35979380)
Or, SSRIs dull you to the point of feeling like an observer (rather than participant) of your own life, which makes one even more depressed and hopeless.
Re:Researchers treat depression by reversing brain signals t... by chresko on Wednesday May 17, 2023 @12:13PM (#35977444)
I would propose the following analogy as an answer:

1 - Person A has the flu

2 - Person B does not have the flu

3 - Person A treats the flu with rest, fluids and antiviral medications

If person B also rested, drank fluids and took antiviral medications, they would not become an unusually healthy person. Person B would not become the new normal.

What you're proposing is that it's OK to be sick. We treat every other form of illness with aggressive treatments. Depression is often ignored, poorly treated or treatment is inaccessible to many people due to cost.

Re:Researchers treat depression by reversing brain signals t... by admax88qqq on Wednesday May 17, 2023 @12:09PM (#35977374)
It's not okay to be depressed because it sucks to be a person who is depressed. Being depressed is not a nice state to be in.

This isn't an "ooo society is wrong" type of situation. Sure there are some societal pressures to appear happy which can make depression _worse_, but depression is still awful regardless of those and we treat it because it's awful.

Re:Researchers treat depression by reversing brain signals t... by johnfn on Wednesday May 17, 2023 @12:32PM (#35977717)
Analogously, what if we took someone who was already full, and then fed them food?

> what if it's ok to be depressed?

I dunno, what if it was _ok_ to be hungry? I don't think this question makes much sense.

Re:Researchers treat depression by reversing brain signals t... by endisneigh on Wednesday May 17, 2023 @03:38PM (#35980175)
But it is ok to be hungry. What’s the depression equivalent of having a completely, literally, full stomach?
Re:Researchers treat depression by reversing brain signals t... by carabiner on Wednesday May 17, 2023 @12:24PM (#35977601)
> apply these same depression treatments, what would happen? some state of euphoria? heightened mood? happiness?

No, usually nothing happens which is why people don't bother abusing antidepressants. These aren't like cocaine or alcohol.

Re:Researchers treat depression by reversing brain signals t... by supernikio2 on Wednesday May 17, 2023 @12:05PM (#35977329)
What brain signals would you reverse on a non-depressed person?
Re:Researchers treat depression by reversing brain signals t... by fpgaminer on Wednesday May 17, 2023 @02:07PM (#35979056)
This line of reasoning reminds me of a common misunderstanding of depression I've seen from people who've never been clinically depressed (1). It's an understandable mistake, albeit potentially dangerous (2).

Depression isn't on the happiness-sadness scale. It's quite tangential to that. In fact, perhaps quizzically, you can be happy and depressed. It's fairly common for people who learn about the loss of a loved one to recall how happy them seemed the day before.

Depression treatment, therefore, doesn't make one "less sad". And consequently it wouldn't make a healthy patient "more happy".

(1) I don't mean this in a negative way towards the comment I'm replying to. Nor am I implying that the commenter believes this. I just noticed a pattern and I'm responding in the spirit of education.

(2) It's okay to not understand depression; not everyone has to be an expert on everything. It only becomes dangerous when providing ill formed advice. Which is unfortunately common when it comes to depression.

Re:Researchers treat depression by reversing brain signals t... by endisneigh on Wednesday May 17, 2023 @03:37PM (#35980153)
The point I was trying to make isn’t about happiness or sadness per se, rather they depression has mental analogs that presumably are improved after treatment.
Re:Researchers treat depression by reversing brain signals t... by carabiner on Wednesday May 17, 2023 @03:43PM (#35980255)
It doesn't need analogs. Depression is mental.

Legitimately what dialogue are you attempting to start?

Re:Researchers treat depression by reversing brain signals t... by endisneigh on Wednesday May 17, 2023 @04:31PM (#35980882)
Sure it does. The dialogue is around the usefulness of depression as a category and status to attribute to someone.

If someone wants to commit suicide what difference does it make if they’re depressed or not, for example.

Re:Researchers treat depression by reversing brain signals t... by mtlmtlmtlmtl on Wednesday May 17, 2023 @05:27PM (#35981464)
I think the more accurate way to conceptualise this is that treatment works by interfering with processes in the brain that cause depression, not that it cancels out the depression by adding enough euphoria/mania/happyness to compensate.

Antidepressants don't typically cause mania in healthy people, but they could paradoxically cause depression.

Re:Researchers treat depression by reversing brain signals t... by endisneigh on Wednesday May 17, 2023 @05:49PM (#35981696)
I was referring more to the article in the OP that “reverses bad signals”.
Re:Researchers treat depression by reversing brain signals t... by pawelmurias on Thursday May 18, 2023 @08:54AM (#35987176)
You can experience depression as being chronically super sad
Re:Researchers treat depression by reversing brain signals t... by d_tr on Wednesday May 17, 2023 @03:32PM (#35980100)
Some symptoms are not OK in an absolute sense. For example, the exhaustion. It can be disabling (along with all the other nice things that go on inside your head) and go on for months without a break.
Re:Researchers treat depression by reversing brain signals t... by throwuwu on Wednesday May 17, 2023 @03:56PM (#35980429)
It’s ok if it isn’t purposeless suffering which clinical depression most certainly is. Having an occasional low mood or a temporary bout of depression due to a bad event is ok because it is informing you that something bad has happened and maybe you should retreat from normal life a bit to deal with it. Just being depressed all the time because your brain got messed up somehow is not a state anyone should be left in.