All mitigations to achieve microkernel like capabilities.
Xen is unfortunately large, and the full hypervisor runs privileged.
With seL4, VM exceptions are forwarded to VMM, which handles them.
From a security standpoint, a VM escape would only yield VMM privileges, which are no higher than that of the VM itself. This is much better than a compromise of Xen, which would compromise all VMs in the system.
Makatea[0] is an effort to build a Qubes-like system using seL4 and its virtualization support. It is currently funded by a NLNet grant.
Hypervisors, userspace drivers, containers, language runtime sandboxes, bytecode deployments, driver and kernel sandboxes (safe kernel / driver guard),container only distributions,...
If you can CI/CD in minutes a reduced kernel+app and reboot in 100ms your network-facing thing (be it nginx or haproxy) you might just take latest vanilla anyway...