Thinking hard makes the brain tired

Re:Thinking hard makes the brain tired by bitL on Sunday April 02, 2023 @12:44PM (#35412458)

Boost B1/B2/B3 vitamin supplementation, take NAD boosters like Niagen or NMN, NAC, potassium and alpha-ketoglutarate to get your neural mitochondria back into shape. Sodium-potassium pump consumes 75% of neuron's energy and too low potassium or too weak mitochondria interferes with it. Too strong mitochondria with low potassium makes it worse as well. NAC is to get rid of metabolic waste, AKG is to make cells more resilient.

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Re:Thinking hard makes the brain tired by Trasmatta on Sunday April 02, 2023 @12:59PM (#35412595)

Supplementation can only do so much when there are fundamental psychological issues at play too

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Re:Thinking hard makes the brain tired by bitL on Sunday April 02, 2023 @01:03PM (#35412646)

Psychological issues often stem from mitochondria not working properly, i.e. neurons not having enough energy to work well. Fix mitochondria and many psychological problems disappear.

See e.g.:

https://pubmed.ncbi.nlm.nih.gov/18979198/

https://www.quantamagazine.org/mitochondria-may-hold-keys-to...

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Re:Thinking hard makes the brain tired by tayo42 on Sunday April 02, 2023 @01:30PM (#35412958)

what makes you think that your mitochondria isn't working properly. reading this it sounds like your throwing a bunch of supplements at something and hoping something else happens. it doesn't sound very scientific.

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Re:Thinking hard makes the brain tired by bitL on Sunday April 02, 2023 @01:49PM (#35413180)

Did you read the second link?

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Re:Thinking hard makes the brain tired by tayo42 on Sunday April 02, 2023 @09:45PM (#35417565)

I don't think that justifies saying its often mitochondira. it doesnt explain why in the first place. it sounds like the depression is caused by an chemical imbalance thing. i dont think you can make sweeping judgements like that and say something like just take some vitamins and youll be cured

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Re:Thinking hard makes the brain tired by bitL on Monday April 03, 2023 @05:21AM (#35420647)

OP talked about burnout which is seen as a lack of mental energy. Mitochondria would be the first thing to look at when it comes to energy as it's a "power plant" that makes cells work.

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Re:Thinking hard makes the brain tired by tayo42 on Monday April 03, 2023 @10:09AM (#35423826)

I think you should read a little of what burnout actually is instead of supplement pseudoscience

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Re:Thinking hard makes the brain tired by bitL on Monday April 03, 2023 @10:18AM (#35423989)

You are accusing me of following pseudoscience yet I am the only person in this conversation to actually post scientific links...

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Re:Thinking hard makes the brain tired by tayo42 on Monday April 03, 2023 @10:47AM (#35424510)

You already expressed you don't understand what causes burnout and what experience is like. It's not just mental energy. Go read about mental health and how people actually experience. I'm not here to educate you

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Re:Thinking hard makes the brain tired by dang on Tuesday April 04, 2023 @02:01PM (#35443610)

Could you please stop posting unsubstantive and flamewar comments? You did that quite a bit in this thread and unfortunately have been doing it elsewhere too. It's not what this site is for, and destroys what it is for.

If you wouldn't mind reviewing https://news.ycombinator.com/newsguidelines.html and taking the intended spirit of the site more to heart, we'd be grateful.

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Re:Thinking hard makes the brain tired by tayo42 on Tuesday April 04, 2023 @02:21PM (#35443895)

Did someone go through my post history and just flag a bunch of posts?

This guy is giving out mental health advice based on not understanding what he is talking about. I think that is dangerous and isn't a place for being polite.

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Re:Thinking hard makes the brain tired by dang on Tuesday April 04, 2023 @02:32PM (#35444028)

Yes, I did, because you've been breaking the site guidelines. We need you to follow HN's rules regardless of how wrong someone is or you feel they are. Could you please review https://news.ycombinator.com/newsguidelines.html and stick to them going forward? We'd appreciate it.

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Re:Thinking hard makes the brain tired by tayo42 on Tuesday April 04, 2023 @03:09PM (#35444486)

Even for unsubstantiated health claims and telling people to go and take unknown supplements? Would you prefer a comment like that gets flagged?

I get the guidelines for inconsequential topics, but pretending something is valid when engaging with something that could be harmful seems like its elevating its legitimacy. In this case there is plenty of reading to do on the topic of burnout causes.

I guess the simplest answer from you would be the answer to this question. If i posted something encouraging people to not take vaccines, how does that discussion get handled? Does every comment and thought really get treated equally with curious responses? I guess to me it seems fair to, be short direct and point out the misinformation even if it appears to be flaming

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Re:Thinking hard makes the brain tired by dang on Tuesday April 04, 2023 @04:50PM (#35445695)

Yes, the guidelines cover this: "Don't feed egregious comments by replying; flag them instead."

https://news.ycombinator.com/newsguidelines.html

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Re:Thinking hard makes the brain tired by tayo42 on Tuesday April 04, 2023 @05:27PM (#35446067)

I see got it.

Anyway stuff like this https://greatergood.berkeley.edu/article/item/six_causes_of_...

is why suggesting taking supplements to cure burnout and dropping an irrelevant link to a study about mental illness is uninformed.

I'll hit report in the future then, thanks for the back and forth and explaining.

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Re:Thinking hard makes the brain tired by Name_Chawps on Monday April 03, 2023 @01:18PM (#35427669)

I think you might find this article relevant:

https://www.lesswrong.com/posts/fFY2HeC9i2Tx8FEnK/luck-based...

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Re:Thinking hard makes the brain tired by Trasmatta on Sunday April 02, 2023 @02:32PM (#35413650)

Fixing psychological issues with supplementation can sometimes be like trying to apply a bandage to a cut on your nose while somebody repeatedly punches you in the face. You should apply the bandage, but it's not going to do much good until you stop getting hit in the face.

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Re:Thinking hard makes the brain tired by bitL on Sunday April 02, 2023 @02:41PM (#35413756)

Alternate take: get your energy levels and body function in order first and then face whatever problem you have.

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Re:Thinking hard makes the brain tired by majkinetor on Sunday April 02, 2023 @02:48PM (#35413803)

Supplementation can also work wonders. There is literray almost zero downside to it except wasting money. So if you have some money to waste, start experimenting.

The above advice is solid, but I would add number of others. CoQ10, C in multiple forms, ALCAR, D, Bromelain, concentrated fish oil, etc.

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Re:Thinking hard makes the brain tired by nuancebydefault on Sunday April 02, 2023 @04:13PM (#35414662)

Personally i'm convinced they work. If and only if you believe in the working of supplements.

I am also convinced they do not work for me, because of the premises.

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Re:Thinking hard makes the brain tired by majkinetor on Sunday April 02, 2023 @04:15PM (#35414685)

What is amazing is you dismissing the entire domain of the science with a single unsubstantiated sentence. Feel free to read some schoolar journals and research papers, rather then popular zines, if that is not too much trouble...

If you could fight deficiency with a mind, we would not have deficiency disesases.

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Re:Thinking hard makes the brain tired by nuancebydefault on Sunday April 02, 2023 @04:27PM (#35414818)

I'm only speaking from experience.

> If you could fight deficiency with a mind, we would not have deficiency disesases.

That is so true. The thing is, a lot of diseases get treated as a deficiency disease.

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Re:Thinking hard makes the brain tired by majkinetor on Sunday April 02, 2023 @04:30PM (#35414848)

Experience is highly overrated. Some stuff may work for you some not, depending on your current state (dynamic thing, daily changing). Many stuff you can't experience but you must measure.

Science is important. In accute phase response deficiency is the norm, as one example.

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Re:Thinking hard makes the brain tired by bitL on Thursday April 06, 2023 @08:33PM (#35476528)

Vitamin B1 won a Nobel Prize in 1929 and solved a major generational illness in Japan. Lack of vitamin B3 has the same symptoms as schizophrenia (look up pellagra) and many people are misdiagnosed with it instead of tested for low brain B3 or genetic defects leading to lower absorption of B3.

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Re:Thinking hard makes the brain tired by TeMPOraL on Sunday April 02, 2023 @08:03PM (#35416799)

> There is literray almost zero downside to it except wasting money.

And/or nasty interactions with prescription drugs when you do it incorrectly.

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Re:Thinking hard makes the brain tired by majkinetor on Monday April 03, 2023 @02:11AM (#35419154)

And nasty depletions due to some drugs when you do it correctly - NSAID against C, beta blockers against CoQ10 etc...

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