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Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by analyte123 on Saturday March 11, 2023 @01:59PM (#35111406)
Kind of bizarre that the author won’t entertain the most obvious explanation given the documented problems with many generic drugs [1]. I guess the difference in this case is that the patients can tell right away.

[1] https://www.npr.org/sections/health-shots/2019/05/12/7222165...

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by Waterluvian on Saturday March 11, 2023 @02:39PM (#35111851)
The difference in Concerta and its generic is chocolate and vanilla to me.

The brand one slow releases very evenly while the generic just slams me with the calm, focused joy followed by a significant emotional low for hours.

Completely unsurprised if an Adderall generic had just as significant impacts.

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by luckydata on Saturday March 11, 2023 @02:59PM (#35112054)
the generic concerta all have a KNOWN issue with manufacturing. The slow release mechanism is mechanic, not chemical, and only ONE generic is manufactured the right way.

https://www.goodrx.com/concerta/certain-generics-are-no-long...

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by joezydeco on Sunday March 12, 2023 @12:45AM (#35117101)
It's literally a plastic capsule with microscopic holes drilled in it. A sponge on one end absorbs moisture and swells at a fixed rate, slowly pushing the methylphenidate out the other side.
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by RyJones on Saturday March 11, 2023 @04:04PM (#35112685)
That is exactly my experience. The brand-name Concerta is a smooth push all day, the generic is terrible.
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by guluarte on Saturday March 11, 2023 @04:05PM (#35112695)
same, generic vs concerta fells very different, the generic fills like a bomb while concerta it's slow and steady.
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by freeflight on Saturday March 11, 2023 @06:28PM (#35113899)
> The brand one slow releases very evenly while the generic just slams me with the calm, focused joy followed by a significant emotional low for hours.

Prolonged-release of an orally drug taken in pill form is a "special feature", it's the difference between regular Adderall and Adderall XR.

There are patented techniques involved to make it work like that, generica manufacturers probably don't have access to those/leave it out to save manufacturing costs.

You can try taking the generica in smaller dosages, to compensate for their lack of prolonged-release, as the symptoms you describe sound like you are overdosing by taking too much in too short of a time.

Concerta doesn't need such manual dosage management, as it also has prolonged-release just like Adderall XR.

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by metadat on Saturday March 11, 2023 @06:34PM (#35113942)
How often do you casually dispense medical advice to strangers? Especially without qualifying yourself as a SME expert (or non-expert), or at the very least providing reference sources or other supporting documentation?
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by djmips on Saturday March 11, 2023 @06:41PM (#35114002)
I see you are dispensing advice. I'd like to see your advice dispensing certification please.
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by freeflight on Saturday March 11, 2023 @07:09PM (#35114399)
> How often do you casually dispense medical advice to strangers?

Semi-regularly, as I work in palliative healthcare.

I'm just not sure why that would be relevant to "medical advice" like "If you experience too intense sympthoms, try lowering the dose" and explaining the differences between instant and prolonged-release drugs?

Some might consider that common sense, which shouldn't need to be pointed out.

But life is hectic and complicated, leading to a lot of overthinking, sometimes we just need a reminder of the simpler and straight forward solutions.

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by aksss on Saturday March 11, 2023 @09:22PM (#35115718)
It’s the internet: let’s stop with all the fourth-degree second guessing of hypothetical dimwits which are extreme edge cases when they exist at all, but are mostly the figments of imagination. Most often, this comes across as very hollow and disingenuous virtue signaling.

Let’s set our expectations higher. The admonishing rhetorical questions are a waste of time to post and quite boring to read. You seem to be aware of the risks of strangers dispensing advice on the internet, despite stated qualifications (which may be imaginary or real). Assume most of humanity is aware of this as well.

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by pseudalopex on Sunday March 12, 2023 @06:12PM (#35126974)
Generic substitutes for extended release medicines are extended release also. The problem is the extended release mechanisms are judged equivalent when they are not.
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by yamtaddle on Saturday March 11, 2023 @07:54PM (#35114951)
Two of our kids are on Concerta and can confirm that the first time we got generics it was very fucking obviously working quite differently (in our case, it manifested like them barely working at all). Took us a little bit to put two and two together, but sure enough, the change was just as we switched (well, got switched) to generics.

Be great if the FDA would ensure that a generic is actually the same damn thing.

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by the_mar on Saturday March 11, 2023 @08:24PM (#35115224)
Slightly off topic, I found out generic of my birth control pill is not mono-cycle, meaning not every pill in the pack has the same dosage, it fucked me up for months. It's not documented anywhere
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by kranke155 on Saturday March 11, 2023 @08:00PM (#35115016)
I’ve found the generic of quetiapine doesn’t work at all.

Certainly not in the same way.

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by novok on Saturday March 11, 2023 @08:11PM (#35115104)
That sounds like your generic is not extended release but an immediate release version, which sound like different medications overall. Maybe split the dose in half and take the second half 4 hours later which is what they usually do when people are taking immediate release? Whoever your doctor is should understand this dynamic...
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by bananaportfolio on Saturday March 11, 2023 @10:56PM (#35116472)
The FDA allows generics to be sold within much looser tolerances than the brand product (variances allowed of +/- 20% of active ingredient per dose.) If you've ever noticed a "brand medically necessary" checkbox on a prescription a doctor has given you, that's what it is there for.
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by bick_nyers on Sunday March 12, 2023 @12:12PM (#35121900)
There's no way that the variance allowed is +/- 20%. That's insane.

Does that also imply that a 30mg Adderall could come out as either a 24mg or a 36mg? In reality that is likely easier for the manufacturer to detect than the individual weights of the active ingredients in a random mixture, but still.

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by pseudalopex on Sunday March 12, 2023 @05:50PM (#35126734)
They measure maximum blood concentration and other parameters. Not just how much of the primary ingredient. But the variance allowed for those parameters is 80% to 125%.
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by bick_nyers on Sunday March 12, 2023 @05:50PM (#35126743)
I see, that makes much more sense
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by brianjking on Saturday March 11, 2023 @02:59PM (#35112041)
The brand name worked significantly better when I took seizure medication with fewer side effects. The differences between the brand name and generic medications were very pronounced.
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by suzzer99 on Saturday March 11, 2023 @05:03PM (#35113249)
I've been on 4 different brands of generic Ritalin. I'm sure I can tell them apart by taking one.

1. Normal (the first one - don't remember the manufacturer - was extremely hard to break in half)

2. Actavis - strong, but slow to hit

3. KVK - strong and hits fast

4. Mallinkrodt - weak

For years Mallinkrodt was the only brand my drug store would get. Now they switched back to KVK and it's like night and day. I only have to do half as much.

Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by weaksauce on Saturday March 11, 2023 @06:03PM (#35113694)
i've worked in the biotech industry and have been to some generics manufacturing plants and they are "up to code" but also a whole hell of a lot jankier than the big name brands.
Re:People with A.D.H.D. Claim Adderall Is ‘Different’ Now. W... by Reptur on Saturday March 11, 2023 @06:16PM (#35113801)
Not that bizarre when you look at NY Times shareholders.