Outlook, Teams, Chrome, COMRAD (radiology RIS), Spotify and InteleViewer (DICOM viewer). Without restarts Spotify stops working, the software loses track of what day it is (it assumes the day prior) and things get slow or unresponsive.

Maybe it’s the software and not the OS. I run all those except COMRAD on a Mac ok though.

Mac and multi display and window location is a special hell. My father is a heavy Photohop user and palette organisation is a daily battle with multi screen. When screens wake up windows and palettes reorganise if the system detects one screen and not two briefly. It’s a big drain on productivity.