MDMA and Psilocybin Are Approved as Medicines for the First Time

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by whythre on Friday February 03, 2023 @07:58PM (#34650106)

… that is only there because you are putting chemicals in your body. ‘Love beyond comprehension’ thanks to a drug doesn’t sound very fun to me, it sounds like something out of Brave New World.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by dwaltrip on Friday February 03, 2023 @08:47PM (#34650476)

While you may have a point, there might be a better way to say it. Everything is chemicals.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Scoundreller on Friday February 03, 2023 @09:08PM (#34650630)

it's not like BNW because you can't really take it all the time. Trick to peak benefit is to space it out. Ideally by several weeks, if not months between sessions.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by graderjs on Friday February 03, 2023 @10:34PM (#34651166)

* * *

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Traubenfuchs on Friday February 03, 2023 @11:33PM (#34651560)

I always offered my parents who won‘t live another 10 years some of my drugs, but they refuse. "We don‘t like loss of control / altered mental states" they say. Meanwhile I just met a young man I am into who is excited to try e for the first time soon when we will go out.

You can really split people in two here, those who actively avoid gaining experience with new states of mind and those that love collecting them.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by litiholofan on Saturday February 04, 2023 @12:06AM (#34651719)

You're gay. They probably just don't want to take drugs and become gay like their son.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by comprev on Friday February 03, 2023 @08:08PM (#34650173)

MDMA isn't called the "love drug" for nothing.

Raves are very friendly places and the chillout/smoking zones are full of interesting people.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Scoundreller on Friday February 03, 2023 @09:01PM (#34650578)

outdoor smoking zones are a good place to cool down every once in a while too, whether you smoke or not.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Traubenfuchs on Friday February 03, 2023 @11:28PM (#34651535)

Friendly? Interesting? I just met sex/love/kissing crazed prey and predators. But I only ever did e at gay clubbings.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by randomopining on Friday February 03, 2023 @08:35PM (#34650389)

Does it make you yearn for that the rest of your life though? Nothing can ever be as impressive as the empathetic openness on a heavy roll with the right people around you

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Traubenfuchs on Friday February 03, 2023 @08:56PM (#34650554)

Yes, yes it does. The desire is always there, garnished with the knowledge that every single hit melts your brain and permanently erodes your serotonin receptors a little bit.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by bamboozled on Friday February 03, 2023 @11:47PM (#34651628)

Hasn’t been my personal, or my friends experience. Got some source ?

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Traubenfuchs on Saturday February 04, 2023 @06:20AM (#34653587)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1071023/

> Although initially it proved difficult to find any cognitive sequelae that correlated with these changes,11 recent animal studies have shown subtle, but lasting, deficits in cognitive behaviorsthat do correlate with the levels of damage to 5-HT systems in the hippocampus.

https://www.frontiersin.org/articles/10.3389/fnins.2015.0044...

> In this study, we found an MDMA-related decline in memory performance on a visual paired association test in the first follow-up period in heavy MDMA users,

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by randomopining on Saturday February 04, 2023 @01:41PM (#34656856)

Do you know any ways to reverse the damage or desensitization?

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Traubenfuchs on Saturday February 04, 2023 @01:58PM (#34657022)

I know of nothing specific.

Living the healthiest lifestyle possible would definitely have a great impact, but that has an impact on anyone who doesn't already live it: Food, nutrition, working out, cardio, meditation, sleep, avoiding negative emotions.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by bamboozled on Saturday February 04, 2023 @11:10PM (#34661754)

In animals ?

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by neom on Friday February 03, 2023 @08:39PM (#34650422)

Regarding your last sentence, if you want to go one step up from that, 2C-B is like MDMA x200 for a "night of fun with someone you love". It's beyond anything I've ever experienced before by a long shot, highly recommend.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Scoundreller on Friday February 03, 2023 @09:06PM (#34650622)

I thought 2-CB right after the peak of MDMA was the way to do it...

Haven't tried yet...

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by tayo42 on Friday February 03, 2023 @09:57PM (#34650936)

2cb made me feel like was having a heart attack for 2 hours and my gf threw up. No where as fun as mdma is

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by neom on Friday February 03, 2023 @10:08PM (#34651005)

Damn that's crazy, I've taken it probably 20/30 times and never had an issue, and taken it with groups of 5 or so folks and never seen that issue, not doubting you at all, just never heard of that reaction. Powder or pill? Are you sure it was good?

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by tayo42 on Friday February 03, 2023 @10:16PM (#34651051)

I bought it as a powder. We snorted a couple mgs. I tested it with one of the reagents and it checked out. I think I'm sensitive to vasocontriction. I'm aways freezing on psychedelics, this one was particularly bad. Shallow breaths, cold, tight chest. If I wasn't on drugs I would have gone to the hospital. Sex was intense though, and light visuals towards the end with trippy thoughts that just shut off at pretty much 2 hours on the dot.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by naasking on Saturday February 04, 2023 @01:15AM (#34652044)

You feel freezing even in MDMA? That seems unlikely.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by tayo42 on Saturday February 04, 2023 @10:10PM (#34661377)

no, thats the not a psychedelic either

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by naasking on Sunday February 05, 2023 @07:25PM (#34671532)

It is considered to be under the broad category of psychedelics as it causes sensory distortions at certain doses.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Traubenfuchs on Friday February 03, 2023 @11:27PM (#34651527)

I am pretty bad with acquiring illicit compounds beyond what the local hardcore gay clubbing dealer sells. Which is usually limited to e, mephedrone, crystal meth and cocaine. The last three being addictive hardcore drugs I won‘t ever try a second time.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by danayfm on Friday February 03, 2023 @10:56PM (#34651308)

I agree and totally have done MDMA while dating someone. But as good as the high was, the breakup was/is the worst of my life because of these moments we had together that were x100 more intense.

Don't recommend doing this if you think you'll later break up.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by snvzz on Friday February 03, 2023 @11:11PM (#34651424)

>Don't recommend doing this if you think you'll later break up.

Meaning, statistically, you simply shouldn't.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by siva7 on Saturday February 04, 2023 @01:50AM (#34652258)

I advise to be careful for everyone trying it out for the first time. Do it only with people you trust and feel safe around. Even then the trip is usually awesome, but after that you gain perspective as you said, and that perspective comes sometimes with the realization that the world around you isn't peaceful and awesome.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by yomly on Saturday February 04, 2023 @03:39AM (#34652820)

I have done my fair share of drugs and as much fun as they were, the experience was nowhere near close to the peak moments of my life to date. YMMV

Proposing to my fiancee, attending my brother's wedding, holding my nephew for the first time, winning my first boxing match, winning life-altering over-leveraged bets on the stock market; these are all experiences that not even the greatest of great trips can hold a candle to, and none of them came with comedowns. I've come to realise that drugs are the fast-food of experiences. You get that great sugar salt and fat rush but it's not really healthy and doesn't taste as great food prepared with love sweat and thought (IMO).

PS if you really love drugs, for me the best of the best is your own adrenaline (again YMMV)

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by Broken_Hippo on Saturday February 04, 2023 @05:07AM (#34653265)

"I have done my fair share of drugs and as much fun as they were, the experience was nowhere near close to the peak moments of my life to date."

That's not what they are saying, though. They said that they've had the happiest moments in their life on it. It might not be the best moment of your life, but you'll be freaking happy about it. There is no real comparison between a chemically-induced happiness and the enriching happiness of big life moments, and the chemically induced happy is definitely its own happy. It makes those big life moments even happier in retrospect, more so in the moment with some lasting long-term effect.

[ Parent | on HN ]

Re:MDMA and Psilocybin Are Approved as Medicines for the Fir... by epistemer on Saturday February 04, 2023 @08:09AM (#34654161)

We really need this to be legal someplace in the world. Fentanyl at this point makes any street pill an insane proposition to me.

I am surprised a country hasn't already embraced a type of psychedelic and MDMA drug tourism.

Fentanyl ultimately changes any moral argument for keeping these drugs illegal.

It is really completely immoral at this point to be nudging people towards fentanyl overdosing.

[ Parent | on HN ]