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Re:LSD microdosing does not appear to improve mood or cognit... by monocasa on Sunday June 05, 2022 @02:33PM (#31633625)
I'm sure there's people who do meth recreationally that say the same thing about my fairly small dosage but daily adderall usage.

There's something to be said for a little bit all the time being as valid as a lot every now and then. They're focused on different effects and facets of life.

In my mind it's 'doing large doses all the time' that's generally a problem (and even then only from a 'hey, you might need to work on yourself a bit and take a deep look at why you're doing that' perspective).

Re:LSD microdosing does not appear to improve mood or cognit... by hirvi74 on Sunday June 05, 2022 @03:43PM (#31634204)
> I'm sure there's people who do meth recreationally that say the same thing about my fairly small dosage but daily adderall usage.

Sola dosis facit venenum (The dose makes the poison)

Also, Adderall (Amphetamine) != Methamphetamine. That is like saying Ethylene Glycol (a common car anti-freeze) is the same as Ethanol (drinking alcohol) or that Peroxide is the same as distilled water. In fact, the substances I listed above are more molecularly similar than methamphetamine and amphetamine.

From my understanding, meth made in quality controlled, lab tested, legally controlled, and medically administered and monitored dosages has amazing results for the conditions it treats. Commonly, dosages are in the 2mg - 20mg range vs. the multiple GRAMS of meth + whatever leftover reaction byproducts in recreational usages.

Also, stimulant medications have a higher safety profile than many OTC medications, so take that for what it's worth.

Re:LSD microdosing does not appear to improve mood or cognit... by monocasa on Sunday June 05, 2022 @04:22PM (#31634490)
> Also, Adderall (Amphetamine) != Methamphetamine. That is like saying Ethylene Glycol (a common car anti-freeze) is the same as Ethanol (drinking alcohol) or that Peroxide is the same as distilled water. In fact, the substances I listed above are more molecularly similar than methamphetamine and amphetamine.

The people I know who have made such a distinction haven't done both. The people I know who have done both tell me that they have essentially the same effects.

> Also, stimulant medications have a higher safety profile than many OTC medications, so take that for what it's worth.

Yeah, I think a lot of OTC medications are essentially grandfathered in to drug policies and would require a prescription if they came out new today.

Re:LSD microdosing does not appear to improve mood or cognit... by eurasiantiger on Monday June 06, 2022 @01:10AM (#31637399)
There have been studies done with amphetamine and methamphetamine where participants have been unable to tell which they were given. No difference in effects.
Re:LSD microdosing does not appear to improve mood or cognit... by leadingthenet on Monday June 06, 2022 @07:48AM (#31639267)
> Adderall (Amphetamine) != Methamphetamine

Have you ever tried both, though? Once you factor out the faster uptake due to that methyl group, it's essentially impossible to tell which is which at equivalent, medicinal doses.

Re:LSD microdosing does not appear to improve mood or cognit... by hirvi74 on Tuesday June 07, 2022 @01:06AM (#31650093)
I've got a lot of experience with the former (medicinally).

Would one be able to tell a difference at a much higher dosage? What about when compared to an equivalent dosage of another CNS like methylphenidate or cocaine?

Re:LSD microdosing does not appear to improve mood or cognit... by leadingthenet on Tuesday June 07, 2022 @01:36PM (#31657666)
> Would one be able to tell a difference at a much higher dosage?

I never dared risk much higher dosages, so I wouldn't know.

> What about when compared to an equivalent dosage of another CNS like methylphenidate or cocaine?

In my experience, one can definitely tell the difference between (meth)amphetamine and methylphenidate / cocaine, at any dose. They are by no means that different, though, and I wouldn't be surprised if a person with no previous exposure to either would struggle to do so. Other CNS stimulants, like nicotine and caffeine, are more obviously different.

This is all purely anecdotal, though I have skimmed studies which also claimed as much, so those might be worth looking into.

Re:LSD microdosing does not appear to improve mood or cognit... by PartiallyTyped on Sunday June 05, 2022 @03:53PM (#31634282)
I am not sure the two are comparable given that LSD does not function on dopaminergic circuits.
Re:LSD microdosing does not appear to improve mood or cognit... by eurasiantiger on Sunday June 05, 2022 @05:35PM (#31635044)
Where do you get that from? In addition to its serotonergic effects, LSD is a D3, D4, D2 and D1 receptor agonist.

https://upload.wikimedia.org/wikipedia/en/2/20/LSDaffinities...

Re:LSD microdosing does not appear to improve mood or cognit... by monocasa on Sunday June 05, 2022 @04:25PM (#31634514)
Re:LSD microdosing does not appear to improve mood or cognit... by PartiallyTyped on Sunday June 05, 2022 @04:43PM (#31634637)
That's because serotonin circuits (where LSD and magic mushrooms act on) are antagonists to dopaminergic circuits [1].

[1] https://moleculeofmore.com/

Re:LSD microdosing does not appear to improve mood or cognit... by monocasa on Sunday June 05, 2022 @05:15PM (#31634931)
What you've described is a mechanism for functioning on dopaminergic circuits.
Re:LSD microdosing does not appear to improve mood or cognit... by bgandrew on Sunday June 05, 2022 @04:40PM (#31634618)
so it's like comparing a downer to an upper, right? not the best comparison in my books.
Re:LSD microdosing does not appear to improve mood or cognit... by PartiallyTyped on Sunday June 05, 2022 @04:44PM (#31634643)
LSD is not exactly a downer. The decreased activity is because serotonin circuits are antagonists to dopamine circuits.
Re:LSD microdosing does not appear to improve mood or cognit... by bgandrew on Sunday June 05, 2022 @04:51PM (#31634713)
I know. I'm just saying there is very little sense in comparing it to adderall.
Re:LSD microdosing does not appear to improve mood or cognit... by sva_ on Sunday June 05, 2022 @05:04PM (#31634848)
I think you can compare it to amphetamines (adderall): Amphetamines narrow your focus of attention, while psychdelics widen it.
Re:LSD microdosing does not appear to improve mood or cognit... by Nuzzerino on Monday June 06, 2022 @01:48AM (#31637568)
> Amphetamines narrow your focus of attention, while psychdelics widen it.

And that's exactly why this study is bogus. Here are the two tests which they used to "measure" cognitive ability. See anything wrong here?

https://en.wikipedia.org/wiki/Digit_symbol_substitution_test

https://en.wikipedia.org/wiki/N-back

Re:LSD microdosing does not appear to improve mood or cognit... by bozhark on Sunday June 05, 2022 @03:23PM (#31634036)
There’s really not.
Re:LSD microdosing does not appear to improve mood or cognit... by monocasa on Sunday June 05, 2022 @03:25PM (#31634049)
I mean, I'm sure there are because I've met them and they've said that to me.
Re:LSD microdosing does not appear to improve mood or cognit... by jamal-kumar on Sunday June 05, 2022 @03:40PM (#31634180)
Same here...

But it's not like you can compulsively load up adderall pills into a pipe to turn into a puddle.

The huge issue I see with tweakers is that they smoke that shit like a joint and will tell you that they're doing it for medical reasons. Hilarious if it wasn't for what that does to you.

Re:LSD microdosing does not appear to improve mood or cognit... by sva_ on Sunday June 05, 2022 @05:02PM (#31634832)
I think people crush up the pills, filter the fillers and snort adderall just like meth in a habitual way (for several days at a time.)
Re:LSD microdosing does not appear to improve mood or cognit... by eurasiantiger on Monday June 06, 2022 @01:12AM (#31637403)
You don’t snort freebase, it is not water soluble.