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A comment on LSD microdosing does not appear to improve mood or cognitive ability: study. Parent comment

Re:LSD microdosing does not appear to improve mood or cognit... by PartiallyTyped on Sunday June 05, 2022 @03:53PM (#31634282)
I am not sure the two are comparable given that LSD does not function on dopaminergic circuits.
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Re:LSD microdosing does not appear to improve mood or cognit... by eurasiantiger on Sunday June 05, 2022 @05:35PM (#31635044)
Where do you get that from? In addition to its serotonergic effects, LSD is a D3, D4, D2 and D1 receptor agonist.

https://upload.wikimedia.org/wikipedia/en/2/20/LSDaffinities...

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Re:LSD microdosing does not appear to improve mood or cognit... by monocasa on Sunday June 05, 2022 @04:25PM (#31634514)
https://pubmed.ncbi.nlm.nih.gov/27544651/
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Re:LSD microdosing does not appear to improve mood or cognit... by PartiallyTyped on Sunday June 05, 2022 @04:43PM (#31634637)
That's because serotonin circuits (where LSD and magic mushrooms act on) are antagonists to dopaminergic circuits [1].

[1] https://moleculeofmore.com/

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Re:LSD microdosing does not appear to improve mood or cognit... by monocasa on Sunday June 05, 2022 @05:15PM (#31634931)
What you've described is a mechanism for functioning on dopaminergic circuits.
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Re:LSD microdosing does not appear to improve mood or cognit... by bgandrew on Sunday June 05, 2022 @04:40PM (#31634618)
so it's like comparing a downer to an upper, right? not the best comparison in my books.
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Re:LSD microdosing does not appear to improve mood or cognit... by PartiallyTyped on Sunday June 05, 2022 @04:44PM (#31634643)
LSD is not exactly a downer. The decreased activity is because serotonin circuits are antagonists to dopamine circuits.
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Re:LSD microdosing does not appear to improve mood or cognit... by bgandrew on Sunday June 05, 2022 @04:51PM (#31634713)
I know. I'm just saying there is very little sense in comparing it to adderall.
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Re:LSD microdosing does not appear to improve mood or cognit... by sva_ on Sunday June 05, 2022 @05:04PM (#31634848)
I think you can compare it to amphetamines (adderall): Amphetamines narrow your focus of attention, while psychdelics widen it.
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Re:LSD microdosing does not appear to improve mood or cognit... by Nuzzerino on Monday June 06, 2022 @01:48AM (#31637568)
> Amphetamines narrow your focus of attention, while psychdelics widen it.

And that's exactly why this study is bogus. Here are the two tests which they used to "measure" cognitive ability. See anything wrong here?

https://en.wikipedia.org/wiki/Digit_symbol_substitution_test

https://en.wikipedia.org/wiki/N-back

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