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Re:Science of Fasting by cko on Thursday May 05, 2022 @12:18AM (#31269414)
Question on caloric restriction. I have read that it is the main reason that fasting (even intermittent) works. I heard mice that ate 40% fewer calories lived way longer or something like that.

I'm a thin dude (6'3" and 165lbs). If I don't force myself to eat I will drop towards 155lbs, as has happened before. I eat in a 6-8 hour window daily but I aim for 2000-2500 calories. What would caloric restriction in this context look like?

Re:Science of Fasting by kuhewa on Thursday May 05, 2022 @01:57AM (#31270035)
I'm not sure why you would want to restrict calories in your case? Even if the work on fasting from animal models carries over to humans beyond the benefits of reducing metabolic syndrome (which is unclear), being underweight is definitely a risk factor for all cause mortality.

If anything it kinda sounds like your natural 'set point' already has you calorie restricted insofar as it would.be beneficial

Re:Science of Fasting by jdkoeck on Thursday May 05, 2022 @01:38AM (#31269925)
Well, at this height, are you not calorie-restricted already?
Re:Science of Fasting by urubu on Thursday May 05, 2022 @01:54AM (#31270013)
Depends on the activity level. According to this calculator:

https://www.calculator.net/bmr-calculator.html

his (assuming a dude) energy expenditure is:

Basal metabolic rate: 1819 cal/day

Sedentary (little or no exercise) 2,183

Exercise 1-3 times/week 2,501

Re:Science of Fasting by watwut on Thursday May 05, 2022 @03:08AM (#31270489)
If he is in the "little or no exercise" category, he should aim to get into "Exercise" category. Exercise (in reasonable amount) is healthy whether you loose weight or not.

He should not be aiming for "basal metabolic rate".

Re:Science of Fasting by cko on Thursday May 05, 2022 @01:56AM (#31270028)
So does caloric restriction in general just mean maintaining a low-ish BMI?
Re:Science of Fasting by kuhewa on Thursday May 05, 2022 @02:04AM (#31270085)
For an animal model I imagine it means being fed less than would have been eaten ad libidum, or less than was eaten by a pair fed individual.

But considering you are probably in like the <= 3rd percentile of healthy humans in terms of BMI, your 'normal' calories are pretty damn low and probably commensurate with what would be considered calorie restricted.

Re:Science of Fasting by cko on Thursday May 05, 2022 @03:30AM (#31270600)
So if I'm eating more and gaining lean muscle, I could still fall under the calorie-restricted category?

Basically I don't enjoy being thin but I do want to live to 120. I already do calisthenics and basketball regularly, just wondering what else I could do to min-max my longevity.

Re:Science of Fasting by kuhewa on Thursday May 05, 2022 @04:59AM (#31271126)
I don't think mechanism is worked out well enough to say for sure that being calorie restricted for someone like you that already is lean and not at risk of obesity related disease would be beneficial.

My first guess would be that even if there are longevity benefits for calorie restriction, depending what the mechanism is, you could either be already enjoying them by virtue of clearly not eating that much relative to your lifestyle and metabolism, or alternatively that any benefits of starving yourself enough to clamp down on mToR or some other hypothesised mechanism may well be counterproductive by pushing you close to malnutrition or just increasing your risk of injury or whatever.

I guess you could do a self experiment if you were really interested, try a fasting mimicking diet regimen where its five days a month every month to get the benefits of calorie restriction, and see if you can maintain lean mass while getting improvement in markers.

Re:Science of Fasting by iamacyborg on Thursday May 05, 2022 @05:40AM (#31271348)
> just wondering what else I could do to min-max my longevity

Stay indoors, don't engage in medium to high risk activity, invest all your money into aging research.

Re:Science of Fasting by JackFr on Thursday May 05, 2022 @07:50AM (#31272134)
Don’t drink alcohol and stay out of cars.
Re:Science of Fasting by 2muchcoffeeman on Thursday May 05, 2022 @02:06AM (#31270103)
I think you should think about it as consuming less energy than your body needs everyday.

This specific commenter could be considered too light for his frame. 165lbs is only 75kg. If anything, eat more and put on muscle.

Re:Science of Fasting by stjohnswarts on Thursday May 05, 2022 @01:57AM (#31270034)
drop 800 calories and watch your weight for a month, you should be able to get a pretty good idea how much.