You can host Seafile yourself, which has end-to-end encrypted libraries[1] and version control. There are also hosted versions listed in their partners page [2] if you'd rather not manage that yourself. Apps are available for most platforms, I believe.

I don't know how good macOS support for FUSE style filesystems is these days, but you could work around the encryption problem by mounting something like an EncFS file system over your cloud drive (Homebrew seems to have it?). It'll make the files virtually inaccessible to other tools (like the GDrive web UI) but it'll protect your files and should keep away most unnecessary sync operations. I don't know if and if or how it conflicts with the GDrive application, though.

[1]: https://help.seafile.com/security_and_encryption/use_encrypt...

[2]: https://www.seafile.com/en/partner/

The only Google Drive/Dropbox like service that I am aware of that does end-to-end encryption is:

https://www.sync.com/

The other solutions would be self-hosted (i.e. mounting an encrypted cloud drive using rclone crypt or using cryptomator in combination with something like Cyber Duck or Mountain Duck)

It looks cool and easy to use, I think this is the only complete solution from the replies, but the other comments were interesting as well.

Google Drive with rclone and the crypt layer (https://rclone.org/crypt/)?

It looks like a command line application, I'm looking for something with a great OS X, iOS, Android and web GUI (and happy to pay for it).

Dropbox looks similar to Google Drive with the same problem (No E2E encryption)

Maybe https://www.arqbackup.com/ works for you? Has E2EE. As far as I know, it’s not open source, but the format is open. I use them to back up files from my Mac to Dropbox.

I also use Cryptomator but that’s just for regular files that I pull from different iOS device to Dropbox.

You can use Cryptomator with the various cloud storage backends.

https://github.com/cryptomator/cryptomator

Try Duplicati. Cross platform, free and supports several backends (google drive, s3 and s3 compatible providers etc). Supports encryption so you have data security.

It won't give you cloud just at the moment, but syncthing supports "untrusted peers" which keep all your files encrypted when they're on that remote.

Nextclouds sync client has 'virtual files' where it only downloads stuff when you need it, or when you mark a file/folder as available offline.

You could try using cryptomator to encrypt and then keep using drive or any other cloud service.

Maybe https://www.skiff.org/