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Re:Longevity FAQ: A beginner's guide to longevity research by grishka on Sunday February 27, 2022 @06:47AM (#30487405)
As someone who follows life extension research closely: all the lifestyle stuff like "eating less" is useless. You can't rejuvenate an organism by changing the external inputs to its natural processes. It's half-measures at best.
Re:Longevity FAQ: A beginner's guide to longevity research by ramraj07 on Sunday February 27, 2022 @08:41AM (#30488315)
Are you sure you’re actually following life extension research as opposed to some “quantified self” hacks?

I’ve personally starved and seen worms live much longer than they normally do, and regularly found worms in plates months after they should have all died. There’s nothing unnatural about an organism going into “survival” mode when food becomes scarce. It’s clearly something that benefits a species survival.

Re:Longevity FAQ: A beginner's guide to longevity research by ericmcer on Sunday February 27, 2022 @12:49PM (#30490630)
Really? It makes total sense that aging is related to cell replication mechanisms breaking down and reducing caloric input slows replication down.
Re:Longevity FAQ: A beginner's guide to longevity research by graphpercolator on Monday February 28, 2022 @10:50AM (#30501178)
We have known this for so long now. The problem is that is not the answer people want.

People want the holy grail, literally. Eat pizza, drink beer while sitting playing video games and take a magic pill that makes you young again.

Re:Longevity FAQ: A beginner's guide to longevity research by jdrc on Sunday February 27, 2022 @06:58AM (#30487496)
fasting does have something to do with longevity (in mice and other animals). Maybe not in humans but it's certainly a valid line of research
Re:Longevity FAQ: A beginner's guide to longevity research by grishka on Sunday February 27, 2022 @07:00AM (#30487514)
What I'm saying is that it doesn't reverse aging, it merely slows it down, and not by much.
Re:Longevity FAQ: A beginner's guide to longevity research by avazhi on Sunday February 27, 2022 @07:17AM (#30487670)
I don't think anybody's claimed that it reverses ageing, and if they have I think they would have clarified that they did mean 'slows' the ageing process. And there's no doubt that caloric restriction and IF both slow ageing relative to a normal caloric intake. I don't have the paper on me atm, but IIRC it was 30% longer lifespan in mice. Now whether you want to say ageing is slowed or that lifespan is increased, and I'm not denying that there's a legitimate difference, but either way caloric restriction is completely legitimate for both, and to the extent you said it's useless, I don't think that's fair at all.

For anybody interested, the mTor pathway is really interesting in this regard, and in general the effects of AMPK on cellular metabolism. TLDR is that in the modern world most people never activate these pathways (since we're always in a fed state). Ostensibly there will be some breakthroughs when we finally learn why these starvation pathways are so beneficial. Inflammation seems a decent guess - eating increases it, and fasting decreases it, as a general rule.

Re:Longevity FAQ: A beginner's guide to longevity research by exhilaration on Sunday February 27, 2022 @01:01PM (#30490741)
Isn't slowing down aging the goal of "longevity"? The word implies extending life, not necessarily renewing it.
Re:Longevity FAQ: A beginner's guide to longevity research by grishka on Sunday February 27, 2022 @11:57PM (#30496580)
Slowing it down feels like a half-measure. Especially knowing that it's a malleable process that can be reversed.
Re:Longevity FAQ: A beginner's guide to longevity research by Cicero22 on Sunday February 27, 2022 @08:02AM (#30487997)
are there other studies on animals / mice which have a larger sample size? the one linked in the post has a sample size of 106 which to an untrained eye seems small. https://static1.squarespace.com/static/5a2069c3ccc5c5325fd05...