It's sobering and makes it really hard to continue working in middle age.
Yeah, I'd rather money be put into quality rather than quantity of life.
I would choose to give my children financial benefits instead of years of late life medicine, even if I could afford to live over 100.
- Retirement age will likely be pushed until 80-85, to avoid long pensions.
- Young people will find it harder to get a job, even harder to get a well-paid one.
How are you gauging “aging has paused or is going backwards slowly”?
All of which to say: there is absolutely no way you are possibly controlling for all variables here. Things off the top of my head that could help with exercise recovery, all of which are more plausible than some poorly tested supplement:
- Changes in exercise type - Changes in exercise duration - Changes in exercise intensity - Changes in exercise form - Weight loss - Sleeping more for better recovery
I find the first 3 episodes to be absolutely stellar and was engrossed the whole hour. Pretty good takeaways.
The more recent ones are a little contentious and, as he himself admits, a little pseudosciency. He even says that these supplements are marginally helpful, and perhaps the most beneficial things is literally to just walk after a meal. Partially as a result, and partially because the recent episodes's concepts weren't explained well, I found myself distracted.
Random-- he makes a comment how the FDA often prematurely bans things e.g. peptides, which greatly hampers researchers' access to these materials.
I am willing to bet it will do more for you than taking NMN.
Peter Attia has discussed this with folks who know a lot more than Sinclair and they have concluded there is no evidence it works. The number one thing you can do to extend lifespan is exercise.
He owns part of the company that makes patented NMN which is just another form of NR which is a another form of very cheap Niacin.
He also owns part of the company that claims he is rolling back his biological clock.
That's not science, that's marketing and profiteering.
NAD production slows down with age and illness. All he is doing is supplementing what was produced more easily by a younger body.
There are a many other factors to aging, most of which cannot be changed (yet) by science.
Nowadays the small pains and aches go away in a few hours, like when I was some 15 years younger. But if I stop the supplementation, the situation reverts to the old bad standard within a month or so.
I also noticed some effect on my visual acuity.
I know this is N == 1, hard to measure precisely and subject to a possible placebo effect.
The key to NAD supplementation is the people who need it are older or ill.
There are a lot of other processes in such bodies that become deficient too.
None of the supplement methods for NAD, Niacin, NR, NMN will boost levels beyond what your body will use.
This is what the NAD cycle looks like, you can see NA (niacin) vs NR vs NMN are each closer to production but the end result is the same of what ends up in the blood vs organs like liver.
https://www.lifespan.io/wp-content/uploads/2019/06/NAD_schem...
There are wild arguments, even with scientific rigor, about NR vs NMN ability to get into cells. It is more likely that genetics matters and it varies from person to person and what else is in their diet.
My impression of Sinclair is that he likes public attention too much and often reports on work in progress with too much certainty, but results like this [1] seem to be fairly impressive.
Retirement isn’t my goal. I want to work full-time until my late 70s, and die in my early-to-mid-80s at the latest. In the meantime, I’ll spend my money flying, traveling, and on my apartment and a fast car.
We'll check back in a few decades...
And even if the problem can be solved, evolution doesn't owe you sufficient intelligence for our species to solve it.
Watching them, and also my mother struggle with health issues at 73, has really changed my perspective on aging. I am very focused on enjoying my health now (at 47). Some people are spry and enjoying life up to their early 90s (my grandparents), but some experience health declines much earlier.
The stoic idea that "there will be a last time for everything" in your life (last time you go for a jog, last hike in the mountains, last time you can move without pain, last time you can travel, etc etc) is how I think about aging. I really try to enjoy the physical health I have now, and keep in mind that it will not last forever.