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Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by fpgaminer on Tuesday January 25, 2022 @02:30PM (#30076773)
> Highly attenuated and extremely mild to non-existent symptoms.

Hospitals are getting overloaded due to Omicron. People are dying in droves. Omicron is by no means mild.

"Omicron may be milder compared to Delta, but it’s not mild. " Source: https://yourlocalepidemiologist.substack.com/p/state-of-affa...

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by nradov on Tuesday January 25, 2022 @03:05PM (#30077283)
A lot of the deaths occurring right now are still from patients that were infected by the Delta variant weeks ago.

Preliminary research indicates that Omicron has an 87% lower fatality rate. Of course that number is a little fuzzy because it's impossible to perform a real controlled experiment.

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4010080

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by tablespoon on Tuesday January 25, 2022 @05:49PM (#30079241)
> Preliminary research indicates that Omicron has an 87% lower fatality rate.

1. 87% less of a lot isn't a little. It can still be a lot.

2. "Fatality rate" isn't a number that just floats in the air by itself. It's a factor in the equation deaths = case_count * fatality_rate, and the case_count term has skyrocketed.

3. Deaths aren't the only thing to worry about. Hospitalizations that don't result in a fatality are nothing to sneeze at. Ditto for other kinds of bad outcomes. Where's the concern about COVID-caused myocarditis?

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by nevermindiguess on Wednesday January 26, 2022 @12:06AM (#30081966)
There’s no way of winning with those like you. You just like the drama of the pandemic too much and want it to stay forever. Even if it killed 1 person a year globally, those like you would probably argue that “even one life is infinitely precious and we should be on lockdown to save it”. Perhaps you feel this is your opportunity of a lifetime to be righteous. Honestly, I am so fed up with so many of you around that I have been hoping for a global nuclear Armageddon between Russia and the USA just to shut all of you up. Don’t forget to wear your mask when you look at the strange bright light in the sky.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by tablespoon on Wednesday January 26, 2022 @01:02AM (#30082310)
> There’s no way of winning with those like you. You just like the drama of the pandemic too much and want it to stay forever....Honestly, I am so fed up with so many of you around that I have been hoping for a global nuclear Armageddon between Russia and the USA just to shut all of you up.

I'm sorry, but it seems you're complaining about a straw man that lives only in your head. Also, there are much easier and more effective ways to deal with things like that than wishing for a nuclear war.

Thanks for your comment, though. It felt nice to read it for reasons you almost certainly didn't intend.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by macilacilove on Wednesday January 26, 2022 @02:15AM (#30082719)
It is not a strawman if it speculates motivations, because people are rarely honest about their motivations, even to themselves.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by tablespoon on Wednesday January 26, 2022 @12:58PM (#30089065)
> It is not a strawman if it speculates motivations, because people are rarely honest about their motivations, even to themselves.

In some contexts that may be true, but internet comments is not one of them.

The GP is just showing us the melodrama that's going on between some characters that live in his head. He was responding to them, not so much to me.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by lamontcg on Tuesday January 25, 2022 @07:30PM (#30080126)
> Omicron has an 87% lower fatality rate.

That is likely due to so many people being vaccinated or recovered.

If you dropped Omicron on the world population in the middle of 2019 I strongly doubt it would be any more mild.

> A lot of the deaths occurring right now are still from patients that were infected by the Delta variant weeks ago.

I guess natural immunity isn't as consistent as vaccination though (which produces exactly zero shock amongst the world's virologists and epidemiologists) and also suggests that Omicron isn't intrinsically mild at all.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by nradov on Tuesday January 25, 2022 @11:04PM (#30081554)
There is now strong evidence that Omicron is significantly milder than previous variants, independent of vaccination levels and natural immunity.

https://peterattiamd.com/covid-part2/

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by lamontcg on Tuesday January 25, 2022 @11:47PM (#30081847)
What needs to be done is a comparative study during an overlapping period of Delta and Omicron infection to rule all out all the confounding factors that happen when looking at waves in entirely separate time periods.

That got done recently for transmissibility recently with the Danish study (which finds no difference in intrinsic transmissibility between Omicron and Delta and that the advantage Omicron has is entirely immune escape):

https://www.medrxiv.org/content/10.1101/2021.12.27.21268278v...

Then your unvaccinated group that you're comparing to in the Delta and Omicron waves are equally susceptible to disease and any cryptic spread and immunity may be present but will be equal.

The South Africa study cannot do this which means they're comparing different time points and they have many confounding factors. That is not strong evidence.

Plus best they get is that Omicron is about 1/4 of Delta which is 1/2 of D614G which is still terrible. That is still just SARS-CoV-2 levels and not the factor of 10 that would turn it into influenza.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by ripper1138 on Tuesday January 25, 2022 @02:44PM (#30076983)
The data in the article makes a pretty compelling argument that Omicron is extremely mild.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by obmelvin on Tuesday January 25, 2022 @03:09PM (#30077341)
I mean...it's possible for something to be both significantly less bad than something worse and also still pretty shitty.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by pelasaco on Tuesday January 25, 2022 @02:54PM (#30077118)
what surprises me is to see how Germany, despite the low number in comparison with the other countries, has capitulated in almost all areas.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by prvc on Tuesday January 25, 2022 @02:38PM (#30076893)
I don't see what the supporting evidence for that conclusion is in the article.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by ygjb on Tuesday January 25, 2022 @03:05PM (#30077268)
It doesn't.

The refrain that Omicron is "mild" is being parroted by people who don't understand what they are talking about. In fact, the Omicron variant (like other COVID variants) is relatively mild among individuals who have been vaccinated.

That hasn't stopped the vast majority of folks yeeting themselves off a dunning-kruger cliff and assuming that they are competent to discuss the topic because they read a medical journal or an opinion piece that aligns well with their own perceptions of COVID and the broad spectrum of economic, political, and medical topics (myself included sometimes).

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by xadhominemx on Tuesday January 25, 2022 @03:08PM (#30077332)
It’s mild relative to other variants for everyone. However, it is still quite dangerous for unvaccinated individuals… CFR is not that high but it is extremely contagious, so it is still killing a lot of unvaccinated people.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by tinus_hn on Tuesday January 25, 2022 @05:17PM (#30078908)
It was mild in South Africa as well, where there really is not a high vaccination rate.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by tablespoon on Tuesday January 25, 2022 @05:53PM (#30079287)
> It was mild in South Africa as well, where there really is not a high vaccination rate.

That's not the only variable. IIRC, South Africa's population is on-average much younger, less obese, and much more likely to have had a previous infection compared to America's.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by tinus_hn on Thursday January 27, 2022 @02:44AM (#30097492)
All these factors would have applied to the other variants the same.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by stefs on Tuesday January 25, 2022 @06:10PM (#30079437)
but a very high rate of previous infections
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by ygjb on Tuesday January 25, 2022 @03:29PM (#30077601)
Your first two sentences are at odds. It is not mild for everyone if it's dangerous for people who have not been vaccinated.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by rsynnott on Tuesday January 25, 2022 @05:17PM (#30078911)
Mild _relative to other variants_ for everyone. That doesn't mean mild in an absolute sense, and for unvaccinated people in particular it can be quite nasty, just not as nasty as previous variants.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by xadhominemx on Tuesday January 25, 2022 @03:30PM (#30077609)
I think my comment makes sense
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by stickfigure on Tuesday January 25, 2022 @03:41PM (#30077737)
They made their choice. It's time to move on.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by lamontcg on Tuesday January 25, 2022 @07:32PM (#30080146)
I'd love to move on, but they're filling up the fucking hospitals.

I have 80 year old parents who need medical care and can't get it right now.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by nicoburns on Tuesday January 25, 2022 @02:41PM (#30076940)
I think Omicron is almost universally mild for those who have had the existing vaccines. And as most people have (here in the UK anyway), I can understand why people are seeing it as mild.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by ygjb on Tuesday January 25, 2022 @03:07PM (#30077309)
There is an ocean of difference between "it's mild because I am vaccinated" and "it's mild", and the bridge across it is being built on the mental and physical well being of our health care providers around the world.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by fivea on Tuesday January 25, 2022 @04:06PM (#30078016)
I'd add that it's extremely disingenuous to hide the fact that high vaccination rates are the sole reason why the same disease spreading like wildfire is not leaving a trail of dead bodies stacked high on it's wake.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by cma on Tuesday January 25, 2022 @03:02PM (#30077227)
Even if it was as mild as flu, with its much higher rate of spread hospitals would probably still be seeing a big surge.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by native_samples on Tuesday January 25, 2022 @02:32PM (#30076802)
Where? In the UK hospitals are quiet for this time of year (less than 80% loaded which for the UK is quiet), and deaths are below the 5 year running average.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by fpgaminer on Tuesday January 25, 2022 @02:41PM (#30076948)
In the U.S. at least:

> There are two states and 618 counties that require circuit breakers (i.e. short-term mitigation measures needed to preserve hospital functioning) at this point because their hospitals are at or above 100% capacity (assuming that the number of staffed beds has not increased in the past week). Medical military personnel have already been dispatched to a number of hospitals across the nation. Nebraska also joined a short list of states that have enacted its Crisis Standards of Care plan. But community-wide efforts to reduce spread desperately need to be taken, too. Fourteen additional states are at high risk of exceeding 100% hospital capacity in the next 1-10 days.

Source: https://yourlocalepidemiologist.substack.com/p/state-of-affa...

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by jbirer on Tuesday January 25, 2022 @02:47PM (#30077032)
Americans also have higher dates of obesity and diabetes though so it doesn't surprise me.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by encoderer on Tuesday January 25, 2022 @02:52PM (#30077097)
It’s mild. Everybody is getting it and that strains hospitals but it’s a mild illness and many infected people won’t even be tested let alone seek treatment.

How much evidence do you need of this being a mild variant?

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by fivea on Tuesday January 25, 2022 @04:11PM (#30078085)
> It’s mild. Everybody is getting it and that strains hospitals but it’s a mild illness and many infected people won’t even be tested let alone seek treatment.

It really is not. It's mild to double- and triple-vaccinated individuals living in highly vaccinated populations. They get the shot, they brush it aside

The poor souls who didn't managed to get vaccinated, or didn't wanted to, represent the bulk of the hospitalized population and deaths.

The key factor is that the world has spent the last year bulking on vaccines, precisely to allow any infection to be at most mild. And now that we're seeing highly vaccinated populations being exposed and developing mostly mild cases are we now supposed to pretend that vaccines don't exist and the disease suddenly got tame? In whose head does this even compute?

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by Closi on Wednesday January 26, 2022 @06:48AM (#30084385)
> The poor souls who didn't managed to get vaccinated, or didn't wanted to, represent the bulk of the hospitalized population and deaths.

This is only part of the picture - it's actually the people that are unvaccinated and are very old or have comorbidities that represent the majority of deaths.

But we also shouldn't exclude that a large majority of people are dying with Covid-19 at the moment rather than because of Covid (i.e. as c20% of deaths at the moment are within a month of a positive covid test, and c5% of the population likely had Covid in the last month, we can imply that 5% of deaths would have Covid anyway if it had no impact on morbidity, so about 25% (at least) of those Covid deaths are people dying with covid. This is likely an underestimate considering Covid is probably spreading in hospitals).

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by encoderer on Tuesday January 25, 2022 @04:26PM (#30078301)
I believe you truly have bought the full narrative. I’m boosted I’m not anti vax but I’ll give you one data point that contradicts your claim:

South Africa vax rate is 52%. Their health officials have declared it to be mild.

It’s mild.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by dang on Thursday January 27, 2022 @03:32PM (#30106125)
Please make your substantive points without personal swipes.

https://news.ycombinator.com/newsguidelines.html

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by kurthr on Tuesday January 25, 2022 @02:52PM (#30077087)
It would appear that a country that is over 90% vaccinated and 60% boosted is having ~440 deaths a day with roughly 15k admitted to the hospital (ignoring simple ER visits) that week. It's worth noting that the 10% unvaccinated (even though skewed younger) are ~5x overrepresented at ~50% of the hospitalizations. It's about half as high as the peak last Jan although ventilators are less in use and treatments are better.

From your dashboard: https://coronavirus.data.gov.uk/

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by iso1210 on Tuesday January 25, 2022 @03:15PM (#30077435)
Pre covid, the UK typically had 1400 deaths a day in the winter. It's a little higher at the moment, but nowhere near 400.

https://assets.publishing.service.gov.uk/government/uploads/...

Be careful about who is in covid because of non-covid reasons that just happen to have covid, compared with those who are in hospital because of covid.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by kurthr on Tuesday January 25, 2022 @03:33PM (#30077648)
Did you look at that plot on page 2?

Choosing what certainly looks like a single dramatic outlier point which is 2 weeks older than the dashboard certainly seems like cherry picking.

Just look at the current dashboard data it shows ~440 deaths per day for the last 2 weeks. Again:

https://coronavirus.data.gov.uk/

Also note that there almost aren't deaths from other flus over the last 2 years, likely because they don't have an R value >1 due to masking etc.

Look, I'm all for getting back to normal and letting the unvaccinated (and old, poor, sick) die off as god intended, but let's not pretend it's all due to a lack of joyful evenings in the pub.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by kurthr on Tuesday January 25, 2022 @03:07PM (#30077311)
Actually, now I'm intrigued. It would appear that the total annual death rate in the UK is about 135k/yr or 370/day. So the last couple of weeks of the current Omicron wave exceeds the typical average death rate from all causes from 2010-2018 (scaled for population).

https://www.ons.gov.uk/peoplepopulationandcommunity/healthan...

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by MikeAmelung on Tuesday January 25, 2022 @03:29PM (#30077602)
Close, you're only off by ~465,000
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by native_samples on Tuesday January 25, 2022 @03:38PM (#30077692)
Up to 70% of the "COVID patients" in UK hospitals at the moment are there for other reasons:

https://www.telegraph.co.uk/news/2022/01/20/call-scrap-daily...

"Call to phase out statistics comes as it emerges that up to 70pc of virus patients in hospital being primarily treated for other problems"

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by Closi on Tuesday January 25, 2022 @02:51PM (#30077086)
In the UK our healthcare system is overloaded though because of 2 years of lockdown policy postponing any elective surgeries.

You are right on your figures though - when you look at excess deaths over 5 years there has been much fewer deaths because of Covid than the official figures would have you believe, but the impact of lockdown will be felt for many years to come.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by native_samples on Wednesday January 26, 2022 @08:42AM (#30085231)
It is both overloaded and not working at full capacity simultaneously, due to chaotic and foolish rules.
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by rich_sasha on Tuesday January 25, 2022 @04:57PM (#30078687)
True, and thank goodness, but also because hospitals kicked out everyone they could ahead of the wave.

In a “normal” winter there would be more regular patients in the hospitals.

Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by iso1210 on Tuesday January 25, 2022 @02:56PM (#30077144)
Do you have a link to UK hospitalisation figures?
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by dzhiurgis on Tuesday January 25, 2022 @02:38PM (#30076899)
UK has somewhat decent (50%) booster uptake
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by OnlyMortal on Tuesday January 25, 2022 @03:08PM (#30077333)
Re:Pfizer and BioNTech launch trial of Omicron-targeted Covi... by iso1210 on Tuesday January 25, 2022 @03:19PM (#30077476)
64.3% currently. 83.9% have had 2 doses.