News for hackers. Stuff that matters.
Re:An Experience with Modafinil by pengaru on Tuesday January 25, 2022 @01:01AM (#30068668)
> 80% of people couldn't distinguish I.V. cocaine from I.V. caffeine in some study I am unable to locate at the moment, which I think involved Nora Volkow from NIH, either as PI or collaborator.

All this tells me is that I'm clearly consuming caffeine incorrectly in the form of coffee and/or tea.

Re:An Experience with Modafinil by samatman on Tuesday January 25, 2022 @08:22AM (#30071469)
Or, and hear me out, people outside of cocaine's traditional region are using it wrong.

The past being a different country, I was fortunate in the early Noughts to be able to purchase Bolivian coca tea bags from an early online drug dealer called Amazon dot com.

They were a fantastic addition to the tea shelf. I would favor a cup of the coca tea when energy was low going into an evening with social plans. Even, bright energy, short acting (duration is two hours roughly) barely feel it fading.

How does that compare to refined cocaine taken intranasally? Remarkably, I can't tell you, I don't touch the stuff. Sure wish I could still buy mate de coca though.

Re:An Experience with Modafinil by rahoulb on Tuesday January 25, 2022 @09:48AM (#30072329)
> How does that compare to refined cocaine taken intranasally?

Immediate, bright energy, short acting (duration is half hour), feel it fading within minutes (which is why you want more)

Re:An Experience with Modafinil by Enginerrrd on Tuesday January 25, 2022 @08:42AM (#30071660)
Bingo.

Coca tea is awesome.

Re:An Experience with Modafinil by sk5t on Tuesday January 25, 2022 @07:59PM (#30080327)
> intranasally

Should perhaps be insufflation

Re:An Experience with Modafinil by samatman on Wednesday January 26, 2022 @08:28AM (#30085107)
It should not be insufflation. Intranasal administration is a synonym for nasal administration you'll find in many papers, it's older.

Insufflation is actually a misnomer for nasal administration, insufflation is blowing something into a person for medical reasons, not using vacuum to pull it into the body.

Now, it's a common misnomer, which I generally let pass without correction. But sauce for the goose is sauce for the gander!

Re:An Experience with Modafinil by sauwan on Tuesday January 25, 2022 @08:16AM (#30071415)
I quit caffeine about 8 years, only having a white tea on occasions. But I love a cup of decaf every so often. One day at work, one of my coworkers swapped the decaf pot with the regular pot and I drank a 16oz mug before I realized what was going on.

I was absolutely lit up and it was an incredible experience. I felt utterly amazing. Like I could take on the world. I had a hard time focusing at work, because I just wanted to be talking to people (not an extrovert) or going for a 10 mile run.

I can't compare it to cocaine, because I've never tried it, but I'm guessing the reason for your perception of it is because of your tolerance to caffeine.

Re:An Experience with Modafinil by cecilpl2 on Tuesday January 25, 2022 @10:33AM (#30072912)
> I felt utterly amazing. Like I could take on the world. I had a hard time focusing at work, because I just wanted to be talking to people (not an extrovert) or going for a 10 mile run.

> I can't compare it to cocaine

Sounds like you just did.

Re:An Experience with Modafinil by jpalomaki on Tuesday January 25, 2022 @02:27PM (#30076726)
Best part of quitting coffee is that you can start drinking it again.
Re:An Experience with Modafinil by katbyte on Wednesday January 26, 2022 @02:30AM (#30082805)
Fairly accurate comparison to cocaine
Re:An Experience with Modafinil by robinduckett on Tuesday January 25, 2022 @04:21AM (#30069912)
Time to mainline it directly into your eyeballs
Re:An Experience with Modafinil by actually_a_dog on Tuesday January 25, 2022 @07:57AM (#30071252)
In all seriousness, taking it sublingually might actually be extremely effective. Sublingual delivery tends to be more effective with lipophillic substances than hydrophilic substances. Caffeine is a bit weird in that it is hydrophilic, but, it is sufficiently lipophyllic to cross cell membranes and penetrate the blood/brain barrier, which is what makes me suspect it would work out well.
Re:An Experience with Modafinil by kortex on Tuesday January 25, 2022 @10:04AM (#30072529)
Sublingual caffeine is definitely a thing. There is caffeinated gum you can get on Amazon. You can feel it kick in almost immediately.
Re:An Experience with Modafinil by actually_a_dog on Tuesday January 25, 2022 @12:23PM (#30074660)
Huh. Technically, that would probably be considered buccal (via the cheek) delivery, but, close enough, right? I had no idea caffeinated gum kicked in significantly faster than pills or drinks.

https://en.wikipedia.org/wiki/Buccal_administration

Re:An Experience with Modafinil by kortex on Tuesday January 25, 2022 @03:27PM (#30077577)
Yep, good catch. "buccal administration" is a bit more obscure so I often just refer to sublingual unless I know the audience.

Mucosal absorption is definitely way faster than pills (unless you chew them) or drink.

One time a friend and I tried making caffeine patches with DMSO as a transport, and put it on our arms with a cotton ball and tape...NOT PLEASANT. Extreme pruritus and erythema at the administration site. Hoo boy were we alert though. Nowadays the gum is perhaps a bit too fast even, it's easy to overdue and I get palpitations.

Follow me for more horrible ideas and biohacks. /s. I don't actually have a channel for my misadventures and shenanigans...maybe I should?

Re:An Experience with Modafinil by bryanrasmussen on Tuesday January 25, 2022 @07:51AM (#30071200)
I have a friend who can't stand the taste of coffee but of course likes caffeine as do we all, and had to import it via mail drop to Denmark in order to get his espresso-equivalent shot in the morning.
Re:An Experience with Modafinil by dpark on Tuesday January 25, 2022 @10:27AM (#30072839)
Import what? Caffeine? Where do you live? I just assumed you could buy that anywhere.

I can’t imagine buying caffeine for its own sake. The effects aren’t good enough. If I didn’t drink coffee/tea I just wouldn’t get any caffeine.

Re:An Experience with Modafinil by bryanrasmussen on Tuesday January 25, 2022 @11:05AM (#30073396)
As I heard it from him, although I haven't tried anything personally, in Denmark there are some restrictions about importing liquid caffeine, he hates to drink coffee and also soft drinks, but getting caffeine from bubble gum does not provide the same level of caffeine and the water with caffeine drinks you import do not have as high a level of caffeine as soft drinks for some reason so he had to import his own and make his own.

Also as I understand: it is against the rules to import it so it will be stopped if caught but not against the rules to have it so you do not get fines or anything on record. Thus if you buy it abroad you can bring it into country with you unless caught in which case they confiscate it. This used to be the same case with Modafinil / Adrafinil and I suppose it is still the same.

Re:An Experience with Modafinil by dpark on Tuesday January 25, 2022 @11:53AM (#30074179)
Ah, I misread. I thought you said import from Denmark. Can you not buy caffeine pills in Denmark? A quick search gives conflicting info.

I don’t know what I would even do with liquid caffeine. But again, I don’t want caffeine badly enough to be looking for alternative ways to get it.

Re:An Experience with Modafinil by bryanrasmussen on Tuesday January 25, 2022 @12:23PM (#30074662)
well this is second hand from him, so that also makes it about 12 years old, but I figured it seemed like the kind of thing they would keep if not get stricter about.

The problem of course is that they want to make sure you don't take too much caffeine and have a problem, so they want to limit the strength of what you can get and my understanding from him was the strength was limited so that it was hard to get anything into you with the strength of a cup of espresso, as ridiculous as that sounds but nanny-statism is a thing.