Re:An Experience with Modafinil
by actually_a_dog on Tuesday January 25, 2022 @07:57AM
(#30071252)
In all seriousness, taking it sublingually might actually be extremely effective. Sublingual delivery tends to be more effective with lipophillic substances than hydrophilic substances. Caffeine is a bit weird in that it is hydrophilic, but, it is sufficiently lipophyllic to cross cell membranes and penetrate the blood/brain barrier, which is what makes me suspect it would work out well.
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Sublingual caffeine is definitely a thing. There is caffeinated gum you can get on Amazon. You can feel it kick in almost immediately.
Re:An Experience with Modafinil
by actually_a_dog on Tuesday January 25, 2022 @12:23PM
(#30074660)
Huh. Technically, that would probably be considered buccal (via the cheek) delivery, but, close enough, right? I had no idea caffeinated gum kicked in significantly faster than pills or drinks.
Yep, good catch. "buccal administration" is a bit more obscure so I often just refer to sublingual unless I know the audience.
Mucosal absorption is definitely way faster than pills (unless you chew them) or drink.
One time a friend and I tried making caffeine patches with DMSO as a transport, and put it on our arms with a cotton ball and tape...NOT PLEASANT. Extreme pruritus and erythema at the administration site. Hoo boy were we alert though. Nowadays the gum is perhaps a bit too fast even, it's easy to overdue and I get palpitations.
Follow me for more horrible ideas and biohacks. /s. I don't actually have a channel for my misadventures and shenanigans...maybe I should?