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Re:S.Africa says vaccines, prior infection help mildness of ... by senectus1 on Monday December 20, 2021 @12:19AM (#29621790)
Now we have large numbers of vaccinated out there I really think we should see a lot less of "new infections" type stats, and a lot more of "in hospitals" type stats... in places with 90-95%+ vaccination rates THAT is the numbers that are important for things like opening up/locking down.

Then break that down to "in hospital and vaccinated with X or having had a previous infection and recovered or unvaccinated and having had no previous infection."

We're not seeing that here in Australia... its all just about the number of new infections. plus a bit of info about Delta/Omicron. it feels like fear mongering not information clarity.

Re:S.Africa says vaccines, prior infection help mildness of ... by lettergram on Monday December 20, 2021 @12:49AM (#29621914)
You actually need to go further, many people are not hospitalized FOR covid. You need those numbers.

Further, we couldn’t contain delta. If Omicron is 10x more virulent (as claimed), then we have no hope. Masks didn’t help, Lockdowns didn’t help.

Luckily, these illnesses are treatable with the plethora of therapeutics that were discovered. Plus, the strains have become less lethal over time.

It is fear mongering on the part of media (to make money) and governments (to seize power).

Re:S.Africa says vaccines, prior infection help mildness of ... by nyokodo on Monday December 20, 2021 @12:56AM (#29621928)
> If Omicron is 10x more virulent

I think you mean “10x more infectious” as virulence is how serious/deadly/damaging the infection is. Omicron is no more virulent and maybe considerably less virulent than previous strains.

Re:S.Africa says vaccines, prior infection help mildness of ... by asimpletune on Monday December 20, 2021 @03:32AM (#29622560)
So I was a little confused about the definition myself, because when I looked it up a while back my iPhone dictionary suggested both as a definition.

Is the key difference that in an infectious disease expert context, virulent means severe and infectious means contagious?

I always thought virulent was ability to spread because that’s what viruses do, but that was way before the pandemic.

Re:S.Africa says vaccines, prior infection help mildness of ... by sterlind on Monday December 20, 2021 @04:56AM (#29622982)
correct. it's confusing terminology, but virulent means severe. so MERS is very virulent (30% mortality) but not very infectious (R0<1). SARS-COV-2 is the opposite.
Re:S.Africa says vaccines, prior infection help mildness of ... by lettergram on Monday December 20, 2021 @05:10AM (#29623061)
You’re correct, brain was working a bit slower late at night -_-
Re:S.Africa says vaccines, prior infection help mildness of ... by raxxorrax on Monday December 20, 2021 @07:20AM (#29624047)
Lockdowns give you a linear factor to flatten the rise of new cases that is relevant even for an exponential curve.

Some said that vaccination proved a 70% protection to infect someone. Makes sense since the time someone can infect others is shortened because of the quicker immune response. I still believe this to be a noble lie however, since we should have seen an effect, but the curves rose just as quickly in vaccinated/unvaccinated countries and as fast as in the first wave.

Re:S.Africa says vaccines, prior infection help mildness of ... by ako on Monday December 20, 2021 @02:22AM (#29622263)
How do you know the masks and lockdowns didn't help? Things might have much worse if not for the masks and lockdowns?
Re:S.Africa says vaccines, prior infection help mildness of ... by Semaphor on Monday December 20, 2021 @12:32AM (#29621838)
We are using hospitalizations here in Germany, but a) it's an even more lagging indicator than infections and b) as a person without a booster shot (I've only been eligible to register for one since today) I appreciate the infection rates.
Re:S.Africa says vaccines, prior infection help mildness of ... by markvdb on Monday December 20, 2021 @02:52AM (#29622384)
You sound motivated to get your third vaccination early. Did you know that it has been possible for any EU resident to get a booster shot in Aachen, Nordrhein-Westfalen since two weeks at least, without an appointment? This might also hold true for other German Laender closer to you.
Re:S.Africa says vaccines, prior infection help mildness of ... by mschuster91 on Monday December 20, 2021 @02:57AM (#29622405)
The booster shots are only after 5 or 6 months, depending on the state - and the bureaucracy "experts" have managed to turn people away because six hours (!) had been missing to make the six month spacing (e.g. https://www.waz.de/staedte/velbert/sechs-stunden-zu-frueh-ke...).

Our bureaucracy and inability to improvise in times of need will kill us all.

Re:S.Africa says vaccines, prior infection help mildness of ... by rajup on Monday December 20, 2021 @03:06AM (#29622451)
The reason boosters are needed after 5 or 6 months is antibody levels apparently drop around that time, booster tops that up roughly speaking. Having a booster dose within that time period does not magically make you more immune.
Re:S.Africa says vaccines, prior infection help mildness of ... by Fnoord on Thursday December 23, 2021 @04:31PM (#29666721)
My son (1, NL) got certain vaccines a few days too early (they should've noticed that when appt was made, and now he has to get the vaccines again, or he is not offficially vaccinated against them. Infuriating but otherwise where do you draw the line with exceptions.
Re:S.Africa says vaccines, prior infection help mildness of ... by qwerty456127 on Monday December 20, 2021 @03:50AM (#29622654)
By the way, isn't it there something like the "forgetting curve" for the immune system which could justify administering boosters in specific intervals and unjustify the naïve "better sooner than later"?
Re:S.Africa says vaccines, prior infection help mildness of ... by Semaphor on Monday December 20, 2021 @06:04AM (#29623464)
I'm in SH, our vaccination site has a big warning that you'll only be able to register 5 months after your last shot. Now I'm at my (boostered) parents over Christmas, so I'll just wait till next year and get it then, it's not as if I'm particularly exposed with no contact to anyone outside the family.
Re:S.Africa says vaccines, prior infection help mildness of ... by dukeofdoom on Monday December 20, 2021 @01:20AM (#29622014)
Ontario provides a breakdown of the data. If you go to the the third graph, click on the cases, you will see a worrying trend. The vaccinated cases are growing exponentially. 2997 vaccinated cases vs 905 unvaccinated cases in the last week.

https://covid-19.ontario.ca/data?fbclid=IwAR2pRUq9GN9EEoDTm0...

Re:S.Africa says vaccines, prior infection help mildness of ... by nawgz on Monday December 20, 2021 @02:22AM (#29622265)
But these are case numbers and not hospitalization numbers… which is the parent’s point, Ontario ICU numbers are stable since nov 20 even with all this omicron news and increased case count
Re:S.Africa says vaccines, prior infection help mildness of ... by iso1210 on Monday December 20, 2021 @04:14AM (#29622775)
At the start, hospitalisations tracked cases by about 2 weeks and ICU another week later. In the UK this is still the case through October, but cases were fairly flat (there were a couple of brief "waves" which peaked in cases about 2 weeks before hospitalisations). About 1 in 40 cases resulted in hospitalisation. Everyone who wanted a vaccine had had both well in advance of those figures.

In the last week daily cases have increased 50%. If this remains with the 1 in 40 case:hospitalisation ratio, then between Christmas and New Year we'll be looking at 2,000 new hospitalisations a day.

This time last year the ratio was 1 in 13 case->hospitalisations, so clearly things are far better.

However if cases are doubling every 4-5 days - with cases 4 days ago being abeing about 100k/day, in a few days time this will be 250k/day, and by christmas 700k a day. Before New Year it will naturally plataeu at 1.5m a day (because that's 1 in 6 of the population getting it in a week, and there just aren't enough uninfected people for it to go around.)

That seems to be the strategy the country is going for.

It's too late to stop it reaching 160k/day, which would be 4k hospitalisations a day - the peak of last year - based on October's admittance rates, and there's very little sign of attempts stop it going further, meaning we could be looking at 8k attempted hospitalisations come new year.

The main hope is that Omicron, combined with boosters (which already have a >80% uptake in over 60s) will reduce that 1:40 ratio

Re:S.Africa says vaccines, prior infection help mildness of ... by nawgz on Monday December 20, 2021 @01:57PM (#29628564)
Yes, I understand ICU beds are a lagging indicator, but search "Ontario Covid Cases" and observe the exponential graph in case count without any movement in ICU count to understand that I already claim the 1:40 ratio is reduced

Further, have you seen the latest theory about the mechanism of Omicron? It grows faster in your bronchus/windpipe[0], and slower in your alveoli, so while the cytokine storm (immune response) side of the disease is still concerning, the risk of pneumonia is greatly reduced. I will not comment on cytokine storm vs pneumonia frequency in terms of long COVID or case severity as I am ignorant in this regard, but I can imagine people need the breathers less if they aren't dying of pneumonia, and I somewhat understood this to be a major issue for ICU capacity. This also explains the increased infectiousness to me, as your bronchus would emit comparatively larger viral loads with each breath than the alveoli if we still believe the droplet and not airborne theory.

[0] https://www.theguardian.com/world/2021/dec/15/omicron-found-...

Re:S.Africa says vaccines, prior infection help mildness of ... by dukeofdoom on Monday December 20, 2021 @02:34AM (#29622304)
We don't know yet if the exponential growth in cases will translate to ICU cases. The Ontario government is worried enough to put in capacity limits and lockdown measures. This will be a big test of the vaccine's ability to prevent ICU cases.
Re:S.Africa says vaccines, prior infection help mildness of ... by refurb on Monday December 20, 2021 @02:35AM (#29622311)
I’m not sure why this is too surprising. Singapore has one of the highest vaccination rates and still tests aggressively.

80%+ of new cases were in fully vaccinated back in August.

Re:S.Africa says vaccines, prior infection help mildness of ... by ceesharp on Monday December 20, 2021 @04:55AM (#29622977)
Who would have thought that there are more vaccinated cases with 76% of the people being fully vaccinated. :)
Re:S.Africa says vaccines, prior infection help mildness of ... by senectus1 on Monday December 20, 2021 @02:14AM (#29622230)
jeez those stats are not as great a result as what I was hoping for. thanks for the link
Re:S.Africa says vaccines, prior infection help mildness of ... by dukeofdoom on Monday December 20, 2021 @02:26AM (#29622279)
In ontario the unvaccinated as a group have to do rapid antigen testing 2 or 3 times per week testing to keep their jobs. So much more likely to report a positive. The "doctors" on 4chan think it's ADE in the vaccinated.
Re:S.Africa says vaccines, prior infection help mildness of ... by senectus1 on Monday December 20, 2021 @06:40AM (#29623722)
ADE?
Re:S.Africa says vaccines, prior infection help mildness of ... by nradov on Monday December 20, 2021 @08:43AM (#29624823)
Antibody dependent enhancement. There are some infectious diseases for which the antibodies created by vaccination actually make it more likely for patients to get infected by the actual virus. There is no reliable evidence of this happening with COVID-19.

https://www.nebraskamed.com/COVID/antibody-dependent-enhance...

Re:S.Africa says vaccines, prior infection help mildness of ... by heyitsguay on Monday December 20, 2021 @12:26AM (#29621820)
Basically agreed, but to me whether "new infections" matters or not hinges on the long-term effects of these different variants in vaccinated people. What's the prevalence of "long COVID" if you're vaccinated? If you're vaccinated and boosted? Is there evidence of any more or less lasting lung damage in chest X-rays than in unvaccinated people?

Hospitalization matters for short-term policy, but long-term damage could end up affecting long-term healthcare policy even more in the coming decades

Re:S.Africa says vaccines, prior infection help mildness of ... by senectus1 on Monday December 20, 2021 @02:10AM (#29622219)
oh long covid is another problem as well I agree, but I think the more immediate issue is checking to see if this new variant is so bad that we need to lock down (seems unlikely) or if we're now fortified enough to let it rip :-/
Re:S.Africa says vaccines, prior infection help mildness of ... by rsynnott on Monday December 20, 2021 @07:42AM (#29624235)
> Now we have large numbers of vaccinated out there I really think we should see a lot less of "new infections" type stats, and a lot more of "in hospitals" type stats... in places with 90-95%+ vaccination rates THAT is the numbers that are important for things like opening up/locking down.

So, the trouble with that is that hospitalisation is a lagging indicator. By the time hospitalisation starts rising rapidly, you could lock everyone in their houses and it would still rise rapidly for another week or so. Which will probably overwhelm your hospitals.

Even in places with 95% vaccination, case counts are still _generally_ a reasonable indicator of where hospitalisation is headed; some fraction of those cases will convert to hospitalisations due to that vulnerable 5%, and due to people for whom the vaccination doesn't work very well (immunocompromised and extremely ill people, generally).

Re:S.Africa says vaccines, prior infection help mildness of ... by thebigman433 on Monday December 20, 2021 @12:33AM (#29621845)
> Now we have large numbers of vaccinated out there I really think we should see a lot less of "new infections" type stats, and a lot more of "in hospitals" type stats... in places with 90-95%+ vaccination rates THAT is the numbers that are important for things like opening up/locking down.

Exactly what should be done. Instead of reporting new cases most prominently, there should be reports on how cities like SF, with 80%+ vaccination rates, have 0, or single digit death averages over the last week. For massive population centers!

Re:S.Africa says vaccines, prior infection help mildness of ... by adgjlsfhk1 on Monday December 20, 2021 @12:46AM (#29621904)
The main problem with using hospitalization is that it lags cases by 1-2 weeks which means it's not ideal for policy making.
Re:S.Africa says vaccines, prior infection help mildness of ... by switch007 on Monday December 20, 2021 @04:30AM (#29622855)
Policy shouldn't be quick, rash judgements. It's got a bigger scope than that. We need longer-term strategies. Quick judgements should be made within an existing policy.

And laws, which take time, for good reason, to propose, debate and pass.

We can't run a country with by changing direction every time case numbers of one particular virus go up or down

Re:S.Africa says vaccines, prior infection help mildness of ... by phillc73 on Monday December 20, 2021 @04:26AM (#29622839)
Austria is using ICU bed occupancy as a key metric now. This was used to justify the most recent lockdown. The publicised critical point is 33% of ICU bed capacity occupied by COVID patients. This page has the data [1].

What I now believe is missing, and would like to see, is the number of ICU COVID patients who are vaccinated and unvaccinated, as well as an age group breakdown. This is the type of data required to make informed decisions. If I had a teenage child, I’d be wanting to understand the true likelihood of them contracting COVID and ending up in an ICU bed, in order to make a decision about vaccinating them against it.

[1] https://covid19-dashboard.ages.at/dashboard_Hosp.html

Re:S.Africa says vaccines, prior infection help mildness of ... by top_post on Monday December 20, 2021 @03:57AM (#29622681)
We don't have 90-95% vaccinated in Australia or any state of Australia. It's of the eligible population and it's excluding the under 12 year olds. The whole covid is mild in children argument aside, the fact is the population simply is not 90+ vaccinated.
Re:S.Africa says vaccines, prior infection help mildness of ... by jen729w on Monday December 20, 2021 @04:16AM (#29622787)
Ahem from the ACT where our 16+ double-dose rate is “>99%”. [0]

I’ll give you the technicality that you said “state” but still, we’re doing pretty good here in the territory!

I had my booster yesterday morning. I’m 45.

[0]: https://www.health.gov.au/sites/default/files/documents/2021...

Re:S.Africa says vaccines, prior infection help mildness of ... by top_post on Monday December 20, 2021 @04:32AM (#29622863)
16+ is not the whole ACT population and was my point. Undoubtedly 99% are great numbers for 16+… but an entire cohort is excluded from vaccination statistics of which are vulnerable to infection.
Re:S.Africa says vaccines, prior infection help mildness of ... by jen729w on Monday December 20, 2021 @01:46PM (#29628403)
Ah, gotcha. Still, with our 12-15 at ~97% you’d have to think that we’re a good city to watch. Nowhere else in the world is this vaccinated. If Omicron takes hold here, we’re all buggered. Thankfully, so far it doesn’t seem to be.
Re:S.Africa says vaccines, prior infection help mildness of ... by landemva on Monday December 20, 2021 @03:05AM (#29622448)
It will be interesting to see if this data is collected, '... having had a previous infection and recovered'. And then did not vax.

It is the control group of the natural circumstance.

Re:S.Africa says vaccines, prior infection help mildness of ... by bluejekyll on Monday December 20, 2021 @12:30AM (#29621830)
While I hope what you are suggesting is the case, “scientists say it is too early to draw firm conclusions” (from linked article). We just don’t know yet what the repercussions of the most recent infections are.

It seems like a pretty big gamble to not be cautious. Masking, vaccines, and avoiding indoor crowds in poorly ventilated spaces seems to be helpful. Probably best to at a minimum continue to do that until we have more concrete evidence.

Re:S.Africa says vaccines, prior infection help mildness of ... by heavyset_go on Monday December 20, 2021 @02:06AM (#29622199)
It's the earliest indicator of all COVID-related trends, and it's the variable the that others depend on.

Every new infection results in rolling the evolutionary dice a few hundred billion times, and is how we get diseases that evade our defenses, and new diseases in general.

Also, being hospitalized isn't the only bad thing about COVID.

Re:S.Africa says vaccines, prior infection help mildness of ... by kkjjkgjjgg on Monday December 20, 2021 @02:26AM (#29622276)
"Every new infection results in rolling the evolutionary dice a few hundred billion times, and is how we get diseases that evade our defenses, and new diseases in general."

That frames it as if that was a new and scary thing and not something that has been going on for millions of years.

Re:S.Africa says vaccines, prior infection help mildness of ... by ggm on Monday December 20, 2021 @12:37AM (#29621867)
There was a Qld newspaper report today proposing some state health departments want to focus on hospitalisations as a functional measure of stress on the system. I also heard anecdotal suggestions that contact tracing was going to be dropped as too unwieldy in the face of ubiquitous infection. I find that very scary, close to a "giving up" mentality.

The hospitalisations measurement, is I think sensible. I still think underlying case rate means something.

Re:S.Africa says vaccines, prior infection help mildness of ... by lettergram on Monday December 20, 2021 @12:45AM (#29621899)
Covid is endemic and increasingly less scary.

> I find that very scary, close to a "giving up" mentality.

Everyone can have a vaccine, there are multiple highly effective therapies and even the risk of death without intervention to the majority of people (under 55) is already astronomically low.

To put it in perspective, if you’re under 30 with asthma, your risk of death from the original covid variant (not the less lethal variants) is the same as being struck by lightening.

We haven’t given up, we’ve successfully mitigated fatalities until we have effective treatments and a vaccine. Now it’s time to move on.

Re:S.Africa says vaccines, prior infection help mildness of ... by iso1210 on Monday December 20, 2021 @04:22AM (#29622825)
I'm 40, and last month I caught some bug from the kids, was in bed for 36 hours with a high temperature, but then was fine after that. PCR tests say it wasn't covid.

This this month I did catch covid. I'm not even sure I'd class it as a bad cold, it was far less debilitating than the bug I had in November - although seems to be lasting longer (4 days of coughing so far). My last vaccine was in July (went positive literally the morning by booster was due).

I suspect most people have either had covid or know someone close who has, and see that the main problem is the effects of restrictions -- not going to work while waiting for results (leading to public transport cancellations for example), kids being kept off even though they feel fine. (One symptom of covid is a headache, but that's because I've been trapped in a house with 2 very energetic very excited children for the last 10 days)

Throw in the constant disregard for the rules that the government has shown, and I can't see the acceptance of restrictions surviving in the UK past January.

The brexity type people I'm 'freinds' with on facebook began covid all in favour of restrictions and vaccines. They are fortunatly still in favour of vaccines, but are increasingly shifting to being anti restrictions. Further restrictions will push them more into the Piers Corbyn echosphere, and that's a bad thing.

Re:S.Africa says vaccines, prior infection help mildness of ... by blitzar on Monday December 20, 2021 @05:24AM (#29623146)
> brexity type people I'm 'freinds' with on facebook began covid all in favour of restrictions and vaccines

My brexity friends started covid feb 2020 - "There have been no white people die of Covid, white genetics are superior to chinese genetics and immune to covid - this is an EU conspiracy to punish the UK for brexit" - since then a few died of covid, most lost parent / aunt / uncle / family member.

Its still 100% an EU plot to destroy brexit.

Re:S.Africa says vaccines, prior infection help mildness of ... by spockz on Monday December 20, 2021 @12:57AM (#29621936)
I think dying from COVID is the least scary part. The long COVID is way more common in my area. People stay ill for longer or lose fitness. We have one acquaintance that now has issues finding the right words. Personally I lost a few points of eye sight in just the three weeks. (Coincidentally we measured just before I got ill.) other friends just are tired quickly all the time.

So I think preventing all that loss of quality of life is also worthwhile.

Re:S.Africa says vaccines, prior infection help mildness of ... by nradov on Monday December 20, 2021 @01:13AM (#29621994)
How do you propose to prevent it? The virus will be around forever and everyone will occasionally be exposed.

https://www.medpagetoday.com/opinion/vinay-prasad/94646

https://www.businessinsider.com/delta-variant-made-herd-immu...

Re:S.Africa says vaccines, prior infection help mildness of ... by spockz on Monday December 20, 2021 @07:27AM (#29624107)
I’m not sure we can completely prevent it. But maybe we can keep a significant portion of the population unaffected while the strains decrease is lethality and effect.

Whether that is a net benefit over the economic consequences of lockdowns and secondary effects of that I don’t know. I wouldn’t even know how to begin answering that question.

Re:S.Africa says vaccines, prior infection help mildness of ... by dukeofdoom on Monday December 20, 2021 @01:39AM (#29622075)
I assume increasing poverty in the world would also count in that equation. I was just watching a travel show today, and the guy said Cuba went from 4 million visitors/year to almost none this year. Can you imagine how much poverty that loss of tourism income brings to an already poor population. And poverty quickly translates to increased excess mortality.
Re:S.Africa says vaccines, prior infection help mildness of ... by rajup on Monday December 20, 2021 @03:10AM (#29622469)
This is absurd. You lost eyesight and you think it's because of "long covid"?
Re:S.Africa says vaccines, prior infection help mildness of ... by spockz on Monday December 20, 2021 @07:24AM (#29624089)
I admit that the statements could have been sharper but I don’t directly relate losing eyesight to long covid.

I’m just trying to say that there are other effects than death which seem more likely and impactful for longer for youthful people as they are more likely to get one of the other effects than they are likely to die from COVID.

In this case my eye care provider has seen more cases where patients lost eye sight after covid. Typically this amount of loss of eyesight is not observed over a single period of three weeks.

Re:S.Africa says vaccines, prior infection help mildness of ... by sjg007 on Monday December 20, 2021 @10:56AM (#29626275)
It's a thing as is erectile dysfunction.
Re:S.Africa says vaccines, prior infection help mildness of ... by 20after4 on Monday December 20, 2021 @01:15AM (#29621999)
> we’ve successfully mitigated fatalities

Mitigated, how exactly?

Re:S.Africa says vaccines, prior infection help mildness of ... by sjg007 on Monday December 20, 2021 @12:40PM (#29627475)
>Everyone can have a vaccine, there are multiple highly effective therapies

Well sorry to say that with Omicron that all bets are off. Two out of 3 mAbs don't work and the third isn't so great. And the covid pills are still a long ways off.

Re:S.Africa says vaccines, prior infection help mildness of ... by ggm on Monday December 20, 2021 @01:00AM (#29621948)
You think that stopping contact tracing is a low risk option? I am less sure, given the news about infection rates in the NT which has much lower vaccine uptake, and in a population with co-morbidities.