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Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by pizzeriafrida on Wednesday November 10, 2021 @11:36AM (#29176668)
Translating a dose in mg to the equivalent amount of dried mushrooms you would likely come across recreationally is quite difficult, but I believe 25mg equates to something like 4-5g of dried mushrooms which would be a full on trip beyond surfaces flowing like water :sweat-smile:
Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by kemayo on Wednesday November 10, 2021 @11:38AM (#29176710)
I did some brief googling on the topic earlier, and the best I could find was "anywhere from 5-20 milligrams of psilocybin per gram of dried mushroom". Which is very unhelpful for working out whether these people took a strong dose by recreational standards. :D
Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by Zircom on Wednesday November 10, 2021 @12:17PM (#29177262)
It's more or less impossible to know the psilocybin content of any one specific mushroom offhand, and it can vary greatly even between mushrooms from the same batch, thus microdosing with actual shrooms is an inexact science. You can grind them up into powder and mix it together to average it out, but the total psilocybin will still be an estimate at best.

There is 4 aco dmt, which is supposedly gets converted to psilocin just like psilocybin and I don't believe is illegal in the US, however it degrades very easily into psilocin if stored incorrectly so can be dicey to have since psilocin itself is still illegal.

Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by johnmaguire on Wednesday November 10, 2021 @02:05PM (#29178990)
Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by amelius on Wednesday November 10, 2021 @12:20PM (#29177312)
Isn't uptake through digestive tract unreliable? Mental disorders require extremely precise dosing, therefore probably should administer intravenously.
Re:Compass Pathways' Phase IIb psilocybin trial shows reduce... by kemayo on Wednesday November 10, 2021 @01:49PM (#29178689)
Most psychiatric medications are applied through eating pills, mind you, so this seems like a criticism that applies to a vast field of medications...