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Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by hayst4ck on Monday May 17, 2021 @07:23PM (#27189572)
There are 2 concrete distinct ideas, but many are conflating both of the ideas. It results in it being very hard to have a conversation because it's unclear which idea people are talking about.

Idea 1: SARS-CoV-2 was engineered in a lab

Idea 2: SARS-CoV-2 was in/around/related to WIV and escaped

Idea 1 was widely debunked by American scientists.

Idea 2 is an idea that there is a considerable body of circumstantial evidence supporting and is certainly the most likely origin in my estimation.

> why these weird rumors about Gain of Function research that no one seemingly looks into etc.

You can read one such yourself: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258702/

  we investigated the receptor usage of the SL-CoV S by 
  combining a human immunodeficiency virus-based pseudovirus 
  system with cell lines expressing the ACE2 molecules
  of human, civet, or horseshoe bat.
Later down on the paper it describes the process by which they did the combination.

Our own American scientists said this process would likely result in biomarkers that were not found in the circulating virus (my layman, not expert, understanding).

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by trompetenaccoun on Monday May 17, 2021 @09:25PM (#27190345)
There is a 3rd option. I'm going to repost a comment I made a few days ago regarding the labs in Wuhan:

The "Wuhan Institute of Virology" is named in a couple of news articles and scientific publications. However what is rarely discussed is that the Wuhan CDC (武汉市疾病预防控制中心), which also has a virus lab and was also researching coronaviruses is in walking distance from that wet market! I took a screenshot of it, in the top right is the Huanan Seafood Market, in the bottom the CDC, which includes a virus lab: https://i.imgur.com/smODVQe.png

Unfortunately you won't find it on Google Maps but anyone who is able to read Chinese can check this themselves. All the early cases were centered around this area, including the hospital that treated the first cases. It's absurd that this is almost never talked about anywhere. On the CDC website they had an open position looking for a researcher to study, among others, exactly the kind of bat CoV that's been identified as most closely related to SARS-CoV-2. This has since been deleted but it could still be accessed during the early days of the outbreak.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by smallnamespace on Monday May 17, 2021 @11:05PM (#27190842)
> It's absurd that this is almost never talked about anywhere

FYI, this really doesn't match my experience. I got curious and Googled about the lab's location myself about a year ago, not long after the outbreak, and found the hypothesis tantalizing, even in the absence of hard evidence.

I've seen ongoing discussion about this since then on various blogs and on Twitter.

As a more meta-comment, we're all in tiny, personalized information silos nowadays based on the sites and communities we frequent. Even a pseudo-public forum like Twitter is not really public - you only see the slice that you follow.

IMO 'nobody is talking about it' is more about how you've curated your own info-stream, rather than about the world at large.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by divbzero on Tuesday May 18, 2021 @01:31AM (#27191541)
To add one more data point, for the past year I’ve been following this story passively — reading articles I’ve come across but never searching actively — and this is the first I’ve heard of the coincident location of the Wuhan CDC.
Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by sitkack on Tuesday May 18, 2021 @02:37AM (#27191844)
Replying to you and @smallnamespace, not only are we in extremely small silos, you can realize how small the silo is by

1) taking sporadic notes, but not full urls

2) attempting to follow your same trail again

I often find I can't even, with knowledge of what I read/saw find the same sources again, using the same tools and sites without basically taking detailed notes. The idea that information is public and can be connected in the same way is preposterous, but only via experience.

If you have an insight, or a linkage between facts and events, please document it in a way that is shareable and findable. I too saw the ad for the virologist post-doc position in the Wuhan lab. I think lab escape of either a wild virus or a slightly modified one is likely. It doesn't mean that it is nefarious.

I think a full text and graphical log of the research process would be highly productive.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by trompetenaccoun on Tuesday May 18, 2021 @11:59AM (#27196485)
That's important advice. The thought of documenting anything didn't even cross my mind in the early days of the pandemic. It was all so blatantly suspicious that I had no doubt large news outlets would report on it any day, and then there would be international pressure for a proper investigation. But that day never came. Instead they started spreading the bat-eating story after Chinese state media claimed the virus originated in the market, without evidence. People don't even eat bat in Wuhan. And when that got questioned they switched to pangolins. To this day no such link was found. And the Wuhan CDC lab was never investigated.

There's so much distraction, hysteria and extremely questionable science reporting. Without having in depth knowledge about Mainland China, I'm not sure if I'd not fallen for some of the misinformation as well. So yes, it's extremely important people document what they see and understand, and share it with other in a way that makes it easily accessible. When many journalists do a bad job at fact checking and questioning their sources, we have to be better than that, else we just contribute to the noise.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by Anapologetos on Wednesday May 19, 2021 @09:37AM (#27208371)
@sitkack

Check out Hunchly - https://www.hunch.ly/

"Hunchly automatically collects, documents, and annotates every web page you visit."

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by CRConrad on Thursday May 27, 2021 @07:14PM (#27309769)
> However what is rarely discussed [...] It's absurd that this is almost never talked about anywhere.

Not all that rarely IME, and certainly not "almost never". It's popped up every now and then for over a year now; here on HN among other places. (OTOH, maybe that was you I saw. :-)

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by phyalow on Tuesday May 18, 2021 @01:36AM (#27191561)
If anyone is interested in the Job posting story: https://www.youtube.com/watch?v=bpQFCcSI0pU&t=122s

Webarchive links are in the comments.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by cameldrv on Monday May 17, 2021 @07:49PM (#27189777)
What do you mean by "engineered in a lab?" No one believes that anyone just typed a sequence into their computer and created it from whole cloth.

On the other hand, the WIV has recently published papers about creating new coronaviruses by combining a gene from one virus with the rest of another virus, as well as other types of modifications to existing coronaviruses. They have active grants to continue with this type of research. They also have acknowledged performing this work in BSL-2 labs, which would not be secure enough to contain SARS-CoV-2 if it were to have been the result of one of these experiments.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by throwawaysea on Monday May 17, 2021 @08:39PM (#27190063)
Wuhan Institute of Virology (WIV) is a BSL-4 lab, but US diplomats were concerned by the untrained staff operating the lab (https://www.washingtonpost.com/opinions/2020/04/14/state-dep...). Even with the best of facilities and staff, containment can be hard. For example, back in 2014 86 lab workers at the CDC were possibly infected with anthrax (https://time.com/2902415/cdc-anthrax-atlanta/) because protocols were not followed.
Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by wk_end on Monday May 17, 2021 @08:58PM (#27190198)
WIV has a BSL-4 lab, but not all the work there was done in it.

> Before 2020, the rules followed by virologists in China and elsewhere required that experiments with the SARS1 and MERS viruses be conducted in BSL3 conditions. But all other bat coronaviruses could be studied in BSL2, the next level down. BSL2 requires taking fairly minimal safety precautions, such as wearing lab coats and gloves, not sucking up liquids in a pipette, and putting up biohazard warning signs. Yet a gain-of-function experiment conducted in BSL2 might produce an agent more infectious than either SARS1 or MERS. And if it did, then lab workers would stand a high chance of infection, especially if unvaccinated. Much of Shi [Zheng-li, head researcher at WIV]’s work on gain-of-function in coronaviruses was performed at the BSL2 safety level, as is stated in her publications and other documents. She has said in an interview with Science magazine that “[t]he coronavirus research in our laboratory is conducted in BSL-2 or BSL-3 laboratories.”

https://thebulletin.org/2021/05/the-origin-of-covid-did-peop...

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by cameldrv on Monday May 17, 2021 @08:57PM (#27190192)
WIV contains a BSL-4 lab, which is fairly new. WIV itself has been around for 65 years. It contains many labs, at various levels of security. It's a huge hassle to conduct work in the BSL-4, and researchers generally would only work in the BSL-4 if they were working with pathogens that required it.

WIV has acknowledged that at least some of their bat coronavirus research was conducted in their BSL-2 labs which have a far, far lower level of security.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by ravel-bar-foo on Monday May 17, 2021 @10:57PM (#27190810)
For context, BSL-2 is usually locked doors, cabinets of filtered air, and easily-cleanable surfaces. PPE is usually a lab coat, gloves, and goggles.
Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by temp8964 on Monday May 17, 2021 @09:57PM (#27190534)
There is a BSL-2 lab in the Walking distance from the seafood market. See trompetenaccoun's comment above.
Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by mellosouls on Monday May 17, 2021 @07:51PM (#27189784)
Idea 1 was widely debunked by American scientists

I don't personally doubt it's a conspiracy theory but would you clarify exactly where "American scientists" debunked this - is it in the link you provided, it's not clear, it appears to only deal with claim 2?

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by throwawaysea on Monday May 17, 2021 @08:15PM (#27189914)
For evidence about debunking, you can check out Twitter threads from Trevor Bedford (bio: https://bedford.io/team/trevor-bedford/) that are linked from https://twitter.com/trvrb/status/1339266367522918400

In this discussion and the older threads he links in there, Bedford basically rules out an 'engineered' virus, does not rule out a lab leak, but leans towards zoonosis (pathogen jumping from animal to human).

-

Here are Thread reader links for the older threads he references:

Were parts of HIV inserted into SARS-CoV-2? https://threadreaderapp.com/thread/1223666856923291648.html

What do the number of amino acid and nucleotide changes tell us? https://threadreaderapp.com/thread/1224207086013149184.html

Which data point are consistent with zoonosis or lab escape? https://threadreaderapp.com/thread/1230634136102064128.html

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by timr on Monday May 17, 2021 @08:31PM (#27190011)
Trevor Bedford is one scientist at the Hutch. He is certainly qualified to have an opinion, but his opinion is not the conclusive determination on the matter. Other scientists whom I respect have different opinions:

https://science.sciencemag.org/content/372/6543/694.1

The other links you provide are rebuttals of particular arguments, but in no way settle the entire question. Knowing that bits of HIV weren't inserted into SARS-CoV2, for example, tells you nothing about whether this virus may have emerged from natural selection experiments in the lab. There are good arguments on both sides, but Twitter, in particular, seems stuck on the pronouncements of early 2020, when nobody knew much of anything about the virus and a certain prominent politician was speculating wildly, thus setting up a left/right polarization over what should be a factual debate.

We need to stop this hostile form of "scientific debate" where one person's opinion is held up as "the science", while all other voices are dismissed as fringe.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by temp8964 on Monday May 17, 2021 @09:10PM (#27190259)
I find the word "debunk" has been frequently used by one political side to label any idea they disagree with.

This is a very strange word. When I read history of science books, this word was almost never used. Change of scientific consensus is not uncommon in the history of science. Scientists disagree with each other, debate with each other, but they don't claim they debunk each other.

I don't believe people use this word in good faith. It seems to be politically loaded power grab.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by mistermann on Monday May 17, 2021 @09:31PM (#27190382)
Misinformation is another word that has become extremely popular in the last year or two.

I don't think very many people think very deeply about the meaning of words, and how subtle changes in the ones that are chosen can influence the collective consciousness. A lot of people even seem to strongly dislike the topic being mentioned.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by brippalcharrid on Tuesday May 18, 2021 @12:32AM (#27191279)
I think that practitioners of Postmodernism have spent a lot of time thinking about the meanings of words that they can cause people to perceive, and that they have had a very successful track record of using this to shift cultural parameters and achieve their political objectives.

They'd probably prefer that you didn't notice they were doing this.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by mistermann on Tuesday May 18, 2021 @12:38AM (#27191295)
Politicians and journalists are probably a bit choked that others are stealing their bit!
Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by JPKab on Monday May 17, 2021 @08:33PM (#27190022)
Define "engineered".

If it was bred in a lab via humanized mice engineered with human ACE 2 receptors, would you consider that? What about forms of "no seeum" splicing?

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by adolph on Monday May 17, 2021 @09:20PM (#27190319)
Also, Dr. Shi was trained by Ralph S. Baric of the University of North Carolina in building “chimera” viruses — taking, for example, the spike protein from a new virus and splicing it to the backbone of a known one like SARS. He invented “no-see-um” techniques that left no trace of the splice.

From

https://donaldgmcneiljr1954.medium.com/how-i-learned-to-stop...

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by noofen on Monday May 17, 2021 @08:46PM (#27190109)
> Bedford basically rules out an 'engineered' virus, does not rule out a lab leak, but leans towards zoonosis (pathogen jumping from animal to human).

Where are all these animals in the wild (since the lab theory has been "debunked") with SARS-CoV-2?

I'd imagine we'd have found tons of them by now, right?

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by Reason077 on Tuesday May 18, 2021 @04:29AM (#27192374)
> "Our own American scientists said this process would likely result in biomarkers that were not found in the circulating virus"

There is debate about that. Interesting article here:

https://thebulletin.org/2021/05/the-origin-of-covid-did-peop...

(It also suggests that one of the loudest early detractors of the "escaped from lab" theory, the main author of the Feb 19, 2020 Lancet letter, had an undeclared conflict of interest because he is president of an organisation which funded Coronavirus research at WIV)

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by isaacremuant on Tuesday May 18, 2021 @03:22AM (#27192041)
Idea 1 wasn't debunked:

https://nicholaswade.medium.com/origin-of-covid-following-th...

It's a long read but a worthy one. Exploring all the options better than the NYT article.

The lack of biomarkers is not proof either way.

Re:More Scientists Urge Broad Inquiry into Coronavirus Origins by rubatuga on Tuesday May 18, 2021 @01:59AM (#27191651)
No, idea 1 has not been debunked.