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Re:Biomarker of Alzheimer's found to be regulated by sleep c... by oarabbus_ on Thursday December 17, 2020 @03:30PM (#25459987)
What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am.

And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and work performance, etc.

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by eecks on Thursday December 17, 2020 @04:57PM (#25461042)
I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned.

It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped.

* I bought blackout blinds and use a sleeping mask (sometimes earplugs)

* I bought a bright light (https://www.amazon.co.uk/gp/product/B07FFJYMVS) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on the light.

* I eat healthier in all regards

* I started working out

* I started walking a lot more

* I stop drinking coffee at 11am (and drink tea after that)

* I stopped some doing some things late at night (after 23:30) (gaming, programming, eating, using my phone)

* I started listening to audiobooks

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by 1experience on Thursday December 17, 2020 @06:07PM (#25461705)
This year I found the most effective method, I have tried everything but wasn't enough: sunshine, flux, sleep hygiene, diet, exercise. Basically the method is as soon as you wake up you start working out, the longer and harder you work out the earlier you will get up the next day.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by tinco on Thursday December 17, 2020 @08:00PM (#25462555)
You're probably right, but it's annoying we need to apply this perfect regime just to fall asleep.

Why can't we just be tired in the evening? I have friends who would fall asleep on the couch while watching a movie if it went past 11pm. Meanwhile I have to do some bullshit ww2 pilot exercise just to fall asleep at 1am.

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by slothtrop on Friday December 18, 2020 @09:23AM (#25467326)
I think some of us genetically are more sensitive to the impact of light, caffeine, etc on the circadian rhythm. There's also other factors like work. Cortisol levels are higher coming off of work and it takes time to wind down.

Think of it this way: there's nothing special about a time zone, and yet we know that if we moved several time zones away, we'd shift. The differences are in light patterns, timing of work and social life, food intake, etc. Incidentally, many of these factors are within our control.

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by kurizu4444 on Thursday December 17, 2020 @08:46PM (#25462871)
They probably aren't getting healthy sleep, which is why they fall asleep so easy. They're actually starved of quality sleep
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by IG_Semmelweiss on Friday December 18, 2020 @02:01AM (#25464559)
Anecdata: Have kids and a full time job. Play sports. Normal stuff. Problem solved

Before kids it was much much harder to fal asleep. Now i can fall asleep faster than them during sotry time.

Its like night and day. Pun intended

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by hertzrat on Thursday December 17, 2020 @05:33PM (#25461396)
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by sprite on Friday December 18, 2020 @06:52AM (#25466213)
Bookmarked for reading later, I think I suffer from this. I normally can’t fall asleep before 2-4am, even if my body is physically tired I often feel like I can’t turn off my brain, once I’m asleep I sleep well and wake up naturally after 6-8 hours. It does seem cutting off screens an hour or so before bed and melatonin sometimes helps.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by washadjeffmad on Friday December 18, 2020 @10:36AM (#25468039)
I have a threshold that if I surpass quickly becomes a chase. My solution is to go to bed at around 8pm and read until I fall asleep, which is sometimes immediate but never usually much past 10pm. That way, I can wake up fully refreshed at 4am, or I can sleep until 7am if I need it.

I use melatonin to reset my sleep cycle if I mess up and end up staying up all night. A mg or two at around 5pm helps me back into my target range, and from there I usually don't need it.

Routines are important. If I didn't try to actively control it, I'd stay awake until the sun came up and then sleep until noon, and I much prefer working in solitude when I first wake up than when I'm mentally fatigued at the end of a day.

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by eecks on Wednesday December 23, 2020 @09:34AM (#25517955)
That's a great resource, thanks for sharing. Maybe I will start drinking in the morning :)
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by wyclif on Thursday December 17, 2020 @08:46PM (#25462867)
Hey, thanks for posting that! It's exactly the information I've been looking for, all in one place.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by dcassett on Thursday December 17, 2020 @10:04PM (#25463337)
To add to this, I found something that seems to help when getting to bed - focusing on the visual artifacts that are there with the eyes closed and wondering what's there. Often I will soon not remember anything else, and other times I will be aware that the mind's eye has started creating vivid and detailed imagery, followed by not remembering anything beyond that.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by abathur on Thursday December 17, 2020 @11:16PM (#25463803)
Alas, poor aphantasiacs.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by submeta on Thursday December 17, 2020 @05:57PM (#25461636)
Can confirm that similar steps plus mindfulness meditation plus becoming father has dramatically changed my sleep patterns. - And I have had sleep disorder for decades. It took two years (and becoming father) and another two years until I adopted the new sleep pattern.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by decafninja on Thursday December 17, 2020 @09:12PM (#25463033)
My wife seems to have this but nothing we've tried helps. She wasn't always like this, prior to my meeting her, she spent a few years working at her family's restaurant where her daily schedule would be something like: - Wake up at 10:00AM - Go to work by 11:00AM. - Get off work at 10:30PM. - Eat "dinner" at around midnight-1AM. - 1AM-2/3AM is free time. - Go to sleep at 3AM, rinse repeat.

She was not like this when she worked an office job (fashion designer), but now she can't get back to a "normal" schedule.

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by realPubkey on Thursday December 17, 2020 @09:05PM (#25462984)
Daily gym is the only thing that really helped me, which makes the corona lockdown very hard for me, basically staying awake all nights since 6 months.

Thanks for the tip with the sleeping mask, I will try.

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by glerk on Thursday December 17, 2020 @07:51PM (#25462488)
Have you tried melatonin? I had something similar to this and taking melatonin 1h before my desired bedtime has changed my life.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by sprite on Friday December 18, 2020 @06:55AM (#25466238)
Does it make you drowsy in the morning? I typically take 7mg and it helps me fall asleep but I feel drowsy the next day.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by slothtrop on Friday December 18, 2020 @09:25AM (#25467355)
It's quite high, you only really need 0.3mg for an effective dose and you get diminishing returns after that in the form of grogginess.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by clw8 on Thursday December 17, 2020 @10:07PM (#25463354)
I have DSPS and 10 mg melatonin works very well for me too.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by madrox on Thursday December 17, 2020 @05:30PM (#25461364)
There's no literature I'm aware of studying links between DSPD and Alzheimer's. However, DSPD is characterized as delayed sleep...not less sleep. As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue.

As someone who's dealt with DSPD in his 20s, I'll refrain from advice. I got no end of people telling me to exercise more, drink less caffeine, or any number of things like I hadn't desperately tried everything. My personal experience was that it naturally got easier in my late 30s, but the less I fought it and the more I worked around it the better I felt. If you are looking for help, I encourage you to check out the DSPD subreddit: https://www.reddit.com/r/DSPD/

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by oarabbus_ on Thursday December 17, 2020 @06:43PM (#25462003)
>As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue.

I usually sleep 9-10 hours and feel very tired all day. If I sleep 11-11.5 hours, then I'll feel rested, but this rarely happens.

Don't get me wrong, there are plenty of days I have an early meeting morning and sleep for 6-7h, but I will feel even more tired than when I sleep "only" 9h. Frustrating because 9h is on the verge of "too much sleep" for most people.

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by slothtrop on Friday December 18, 2020 @09:27AM (#25467365)
Ever get checked for sleep apnea or the like? It sounds like unrefreshing sleep, it's unlikely that you need more time in bed as usually this makes things worse leading to fragmented sleep / more awakenings.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by IG_Semmelweiss on Friday December 18, 2020 @02:04AM (#25464576)
You may have apnea. Do a sleep study or get a PC noise detector software that records nighttime noise changrs.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by JamesBarney on Thursday December 17, 2020 @10:46PM (#25463582)
As you know it's hard to get long refreshing sleep when you have DPSD need to be up by 8.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by slothtrop on Friday December 18, 2020 @09:21AM (#25467296)
Well are you getting a full night's sleep? If so that seems fine. You can still get sufficient light exposure in the daytime to better anchor your circadian rhythm, and increased vitamin D3 intake helps to this end (in the day).

If you're intent on shifting your circadian rhythm backwards, you'd have to get up earlier in the morning at a consistent time and try to eschew what might delay your onset, i.e. blue light emitting electronics, before bed. You can use a blue light filter like flux for that in the evening to help. more on that here - https://insomniasos.net/

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by rriepe on Thursday December 17, 2020 @05:01PM (#25461088)
Have you tried biphasic sleep? A cycle with one 2-7am sleep and a significant afternoon sleep (don't call it a nap-- at least 90 minutes) would get you enough sleep. It's easier to carve out that 90 minutes than it is to change all the things you need to change to shift your natural cycle.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by oarabbus_ on Thursday December 17, 2020 @06:44PM (#25462011)
Maybe I should give this a try. I've never been a nap person unless I got <5-6h of sleep the previous day, but seems worth a try.
Re:Biomarker of Alzheimer's found to be regulated by sleep c... by rriepe on Thursday December 17, 2020 @07:18PM (#25462272)
A lot of biphasic sleepers claim to do one 4.5h session and one 1.5h session, and that it's like a hack on getting less sleep. You might be one of those. I need 8 in either mode.

Earplugs and a sleep mask are helpful if you're having trouble in the second phase.

Re:Biomarker of Alzheimer's found to be regulated by sleep c... by temp43t453 on Thursday December 17, 2020 @05:15PM (#25461240)
if you could allow yourself to get 4 hours of sleep at midday (14-15 to 18-19) then do it, and go to sleep at 2-3 am for the other, longer part