Sometimes a Fiat is the only reasonable option. That was the case when I bought my smallest car. Despite the small exterior size, the 500L is really roomy on the inside. It works for a person who is 6'10" (208 cm) tall, leaving enough room to sit up straight and wear a hat. None of the normal large cars (SUV, minivan, pickup, etc.) were as good. With the short length and small turn radius, parking is very easy.
I also own a top trim mid-sized luxary SUV and I'd say the limited pacifica (plus all packages) is easily the go-to option for comfort on road trips. Its no contest how much better something like that is compared to what basically equates to a larger sedan with a big trunk. Maybe something like a suburban or a yukon xl could compete but thats about all I'd think might.
The ride itself is great, and its not noisy. There's an active noise cancellation system, not sure if it does anything as I don't think I can turn it off to compare.