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Re:First person receives Pfizer Covid-19 vaccine in UK by Wintamute on Tuesday December 08, 2020 @06:27AM (#25343977)
Just as a side note, asymptomatic spread is a contested topic. If asymptomatic spread were a major driver of infection, this would be the first respiratory virus to work that way.

Sources:

- Nature study, 20th Nov https://www.nature.com/articles/s41467-020-19802-w

- Maria Van Kerkhove, head of the WHO Emerging Diseases and Zoonosis unit https://www.youtube.com/watch?v=NQTBlbx1Xjs

- Fauci in 2018 https://www.youtube.com/watch?v=vrAvjU2LBkg&feature=emb_titl...

Re:First person receives Pfizer Covid-19 vaccine in UK by madeofpalk on Tuesday December 08, 2020 @06:33AM (#25344008)
My casual understanding was that there werent really any asymptomatic spreaders, just "not symptomatic yet". Is this wrong?
Re:First person receives Pfizer Covid-19 vaccine in UK by bamboleo on Tuesday December 08, 2020 @09:01AM (#25345147)
That’s just word play. I’m asymptotic today, symptomatic tomorrow.

I, asymptotic young person with nCoV 2, am spreading it today. The “yet” part is completely irrelevant to this point in time.

Re:First person receives Pfizer Covid-19 vaccine in UK by frobozz on Tuesday December 08, 2020 @10:07AM (#25346103)
This is one of those situations where the overlap between colloquial and technical usage can cause confusion when one leaks into the other.

In colloquial usage, asymptomatic encompasses presymptomatic. In technical usage, they are different.

If you develop symptoms, then when you were a carrier before then, you were presymptomatic, rather than asymptomatic.

Re:First person receives Pfizer Covid-19 vaccine in UK by Wintamute on Tuesday December 08, 2020 @06:55AM (#25344138)
I'm not aware of stats relating to how many asymptomatic individuals go on to develop full blown symptomatic Covid-19. My assumption is that testing PCR positive while remaining asymptomatic the entire time is by far the most common experience.

Of course, whether you go on to develop symptoms or not, its still highly pertinent information if asymptomatic spread is not a major driver of infection. As long as you self isolate upon symptom onset that should be enough. It does call into question whether isolating the apparently healthy is an evidence-based public health policy intervention though.

Re:First person receives Pfizer Covid-19 vaccine in UK by AlanSE on Tuesday December 08, 2020 @08:45AM (#25344915)
Truly asymptomatic spread is not a major driver of infection. There are been some major public relations problems when an organization said this, and were mistaken to mean pre-symptomatic, but the science is pretty clear.

We used to think true asymptomatic infections (never develop any symptoms but test positive) were ~50% of those infected. More recent research puts it at closer to ~20%. Again, some reporting bungled this by reporting studies from controlled populations (like a cruise ship) before they knew if cases were asymptomatic or pre-symptomatic, causing people to quote the number as the former, when it was really a mix.

COVID spreads like wildfire by pre-symptomatic people. There are mountains of evidence to support this. Spread by asymptomatic people is speculation.

> Of course, whether you go on to develop symptoms or not, its still highly pertinent information if asymptomatic spread is not a major driver of infection.

Not sure, but I think you may be using the word "asymptomatic" to denote pre-symptomatic in this sentence.

> As long as you self isolate upon symptom onset that should be enough.

It is not enough.

Re:First person receives Pfizer Covid-19 vaccine in UK by alistaira on Tuesday December 08, 2020 @09:34AM (#25345612)
If a person has no symptoms, I think it is reasonable to say they are "asymptomatic".

There is absolutely a difference between 'yet to have' and 'never will have' but I think it is potentially confusing to attempt to delineate between asymptomatic and "pre-symptomatic".

The main concern with messaging that causes confusion in this regard is that a superficial reading of "asymptomatic doesn't spread virus" would imply that if you aren't symptomatic, you aren't a danger.

Re:First person receives Pfizer Covid-19 vaccine in UK by scotty79 on Tuesday December 08, 2020 @09:34AM (#25345611)
Every symptomatic person was asymptomatic before they started getting their first symptoms. It might have been few days that they already had the virus on their mucus membranes.
Re:First person receives Pfizer Covid-19 vaccine in UK by doliveira on Tuesday December 08, 2020 @07:11AM (#25344214)
Asymptomatic individuals never develop any symptoms.

And the viral load is high two days before the symptoms onset. If you want a proper RCT about it, good luck approving it in an ethics committee.

Re:First person receives Pfizer Covid-19 vaccine in UK by raverbashing on Tuesday December 08, 2020 @07:02AM (#25344158)
This is missing the point and reeks of intellectual dishonesty.

Asymptomatic has a strict definition. You get the virus and nothing happens to you. This is what the WHO and Fauci are referring to.

But most "asymptomatic" cases aren't. They are either paucisymptomatic (you have mild symptoms - maybe too mild to notice) or pre-symptomatic.

Obviously if people were only contagious if showing symptoms, the pandemic wouldn't be.

Re:First person receives Pfizer Covid-19 vaccine in UK by Wintamute on Tuesday December 08, 2020 @07:27AM (#25344310)
I made a new point, so am I missing my own point? Confused.

> Obviously if people were only contagious if showing symptoms, the pandemic wouldn't be.

I don't think that is obviously the case at all. It would have to be proved. The dominant vectors of contagion are not yet well understood - we could be dealing with very highly infectious airborne virus, that is capable of spreading widely from a relatively small number of symptomatic and pre-symptomatic super spreaders.

The fact remains that current public health interventions orientate around isolating individuals whether they are symptomatic, asymptomatic or paucisymptomatic. Moreover, to greater and lesser degrees we also isolate the healthy, assuming them to be asymptomatic in an abundance of caution. Considering the negative non-covid related knock on effects of these policies its at least worth investigating isn't it?

Re:First person receives Pfizer Covid-19 vaccine in UK by raverbashing on Tuesday December 08, 2020 @08:05AM (#25344551)
> we could be dealing with very highly infectious airborne virus, that is capable of spreading widely from a relatively small number of symptomatic and pre-symptomatic super spreaders.

The calculated R0 does not support this theory. Measles works this way. R0 for Measles is > 10

> that current public health interventions orientate around isolating individuals whether they are symptomatic, asymptomatic or paucisymptomatic

Everywhere, the restrictions are higher if you were tested and/or is suspected of having Covid. Of course a lot of people DNGAF about the restrictions, which is part of the problem.

Again, if your theory that people showing no symptoms do not transmit the disease then it should be super easy to go around and start finding people spreading it. But it isn.t

Re:First person receives Pfizer Covid-19 vaccine in UK by tialaramex on Tuesday December 08, 2020 @07:24AM (#25344285)
I followed the New Zealand press conferences very closely and so often the initial story was this person had no symptoms, total surprise to them that they had the virus, and then a day later oh, well, actually they did have some symptoms but they didn't realise it was COVID-19...

People will say to themselves well, it's just a cough right? Just a cough. I can't have COVID-19 that's something other people get, those people are sick but I'm healthy, this is just a cough. And that allows the virus to spread.

Re:First person receives Pfizer Covid-19 vaccine in UK by tzs on Tuesday December 08, 2020 @07:41AM (#25344394)
> They are either paucisymptomatic (you have mild symptoms - maybe too mild to notice)

Or you notice them but because they also match symptoms of colds and allergies, and you’ve been getting them on and off for months, you assume they aren’t COVID.

I don’t think there has been an interval longer than a week since February during which I didn’t have at least a couple symptoms that could have been COVID.

I’ve not had the taste/smell loss, and all my contact with other people has been masked and brief, and I’m in an area where spread has been low, so I’ve probably not had it, but I wish we had widespread cheap testing so I could know.

Re:First person receives Pfizer Covid-19 vaccine in UK by tomp on Tuesday December 08, 2020 @09:43AM (#25345752)
> Or you notice them but because they also match symptoms of colds and allergies, and you’ve been getting them on and off for months, you assume they aren’t COVID.

Exactly. I have occasionally runny nose combined with sporadic sneezes and coughs pretty much every winter. If someone like my had so "mild" COVID symptoms they would consider themselves asymptomatic (paucisymptomatic?), and rightfully so. (My actual COVID symptoms were not as mild, but not very serious either.)

Re:First person receives Pfizer Covid-19 vaccine in UK by Wintamute on Tuesday December 08, 2020 @07:44AM (#25344411)
> I don’t think there has been an interval longer than a week since February during which I didn’t have at least a couple symptoms that could have been COVID.

It's remarkable the number of people anecdotally reporting similar symptoms - often out of character for otherwise robustly healthy individuals. I'm guessing some sort of psychosomatic response to the year's stresses.

Re:First person receives Pfizer Covid-19 vaccine in UK by cassianoleal on Tuesday December 08, 2020 @07:58AM (#25344509)
Is it that out of character though?

I have been having the same, but the main reason why I notice it now is that every time I have any symptom, even the mildest of them, I take notice and consider the possibility of Covid, whereas in past years I would forget about them if even notice at all.

For context, I'm a fairly healthy individual who hasn't seen a GP or other medical doctor in at least a couple years, probably longer. Last time I've been to one was because of exercise-related injuries.

Re:First person receives Pfizer Covid-19 vaccine in UK by Wintamute on Tuesday December 08, 2020 @08:44AM (#25344889)
> every time I have any symptom, even the mildest of them, I take notice and consider the possibility of Covid

This is hypochondria isn't it? A pathology in its own right, no doubt caused by current events.

Re:First person receives Pfizer Covid-19 vaccine in UK by cassianoleal on Tuesday December 08, 2020 @01:11PM (#25349149)
Of course it isn't. I don't even bother about mild symptoms, much less go see a doctor or look for a cure. I just take note.

It's not hypochondria, it's simple awareness.

Re:First person receives Pfizer Covid-19 vaccine in UK by raverbashing on Tuesday December 08, 2020 @07:46AM (#25344427)
Oh I totally understand you

That being said it seems the most specific symptom is loss of smell/taste so unless you have that it's probably something else (disclaimer: not a doctor and this is not medical advice)

Re:First person receives Pfizer Covid-19 vaccine in UK by doliveira on Tuesday December 08, 2020 @07:26AM (#25344297)
12 months in, I'd say we can already claim it more than "reeks": it is full-blown intellectual dishonesty. Viral load peeks before symptoms onset, we have quite a few case studies of transmission, but these people apparently want some dozens of RCTs before admitting it.
Re:First person receives Pfizer Covid-19 vaccine in UK by mikepurvis on Tuesday December 08, 2020 @09:59AM (#25345984)
In Ontario (as elsewhere), there's been a giant ramp up in cases since the start of September, with an accompanying discussion about whether or not reopening schools is the cause. But a recent testing blitz at a single Toronto school uncovered 26 infected individuals scattered across 18 classrooms:

https://www.theglobeandmail.com/canada/toronto/article-stude...

Still not obvious one way or the other about whether these students and staff are spreading it amongst themselves or if they all got it from other symptomatic cases in the community and independently brought it to school with them. But either way, it's sobering how much of it is going undetected.