What do you think is going to kill enough people to create such an unprecedented selection pressure?

We will deliberately genetically engineer ourselves.

A few people, I have no doubt. When do you think even half the population will be willing and able to afford doing it?

The desperate poor aren’t going anywhere.

When/if the engineered kids turn out to be really great people, most parents will want them.

Desperate poverty is rapidly disappearing across the world. Look it up!

It does, but that doesn't mean that the masses will be able to afford it. Its like you've never seen a cyberpunk dystopia scenario. Honestly, this is I think for now our default.

It’s actually the other way around. Women’s hips are getting narrower because the women that used to die at birth (because of too narrow hips) now survive with Caesarean cuts.

When genetic screening becomes common, gene-based persecution and holocaust can happen maybe?

Since most mutations are bad for you, wouldn't you want to screen for fewer mutations and end up with less change?

I doubt we'll figure out how to do genetic reprogramming on people. It seems like patching a few SNPs isn't going to do much.

Unless everyone starts modifying newborns, it's more like everything around us will evolve more in the coming 500 years and would be unrecognizable to us from now.

Our own evolution is slow, but because of our numbers and tech, we're modifying everything around us at an unbelievable pace.

Hopefully the Falklands will still be around.

There will be no selection pressure.

As long as whether you can survive and make children is independent from your gene, Evolution never occurs.

There is still selection pressure today, not because you are too weak physically to make children, but because of sexual selection. Many people have a hard time finding a partner, often due to genetic issues. On the other hand, many people have genetic traits that help making them highly attractive and able to give their genes to many people.

So selection is still around, but nowadays we select for different things than nature used to when medicine wasn't as well developed as it is today.

Note that this selection alone won't cause any genetic change faster than what existed in the past. What really accelerates changes in the gene pool is us deliberately doing them. We'll start with eliminating hereditary diseases, but I don't think we'll stop there. We'll likely study which genetic variants give rise to desirable traits and then make those mutations to upcoming children of interested individuals.