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Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by TulliusCicero on Monday November 09, 2020 @09:24AM (#25035072)
Have there historically been issues with vaccines causing problems for the long term that didn't show initially?

I've never heard of such a thing, but then again I have only a surface understanding of vaccines.

Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by bluGill on Monday November 09, 2020 @09:30AM (#25035142)
There have been a few cases. However we think we understand why they happened and so it won't. Anything is possible.

If you are a doctor/nurse working in a covid ward we know for sure that the risk whatever happens long term is a lot less than the risk of getting covid. For someone like me who has no reason to go anywhere (I'm not even allowed in the office until this pandemic passes) I can afford to wait until there is more data - and I also have to because I'm low on the list of those who will be vaccinated because I'm relatively low risk of getting it.

Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by howlgarnish on Monday November 09, 2020 @09:37AM (#25035223)
Pandemrix causing narcolepsy comes to mind: https://www.who.int/vaccine_safety/committee/topics/influenz...
Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by charlesdm on Monday November 09, 2020 @09:26AM (#25035094)
I have no idea, that's why I am asking. I'm hoping someone could clarify with decent knowledge on the matter.

I vaguely remember this story (from years ago) about a drug or vaccine during the 70s, where apparently everything was fine but then kids (or kids of kids, can't remember) ended up with birth defects.

Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by _Microft on Monday November 09, 2020 @09:30AM (#25035151)
You might be thinking of https://en.wikipedia.org/wiki/Thalidomide_scandal

The name of the drug was "Contergan" in german which german-speaking readers might recognize more easily.

Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by abainbridge on Monday November 09, 2020 @10:37AM (#25035823)
Or Primodos (https://en.wikipedia.org/wiki/Primodos). Or Sodium Valproate (https://www.bbc.co.uk/news/world-europe-39657139). These cases really undermine my confidence in the system.
Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by _Microft on Monday November 09, 2020 @10:52AM (#25036005)
Be aware of availability bias here. If a medication did not make it into the news because of problems, we are a lot less likely to have ever heard of it.
Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by abainbridge on Monday November 09, 2020 @12:00PM (#25036833)
Agreed. But in the case of Primodos, there were cover-ups with government involvement for decades. The end result was that Matt Hancock apologized. That was it. No holding to account. No fixing the system so it wouldn't happen again. That's what undermines my confidence in the system.
Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by thu2111 on Monday November 09, 2020 @11:21AM (#25036349)
That's Thalidomide which wasn't a vaccine.

A more relevant example is Pandemrix, a flu vaccine launched in the EU in 2009. A year later it was discovered that it seems to increase the risk of narcolepsy in teenagers sixfold. The vaccine was produced and licensed in an expedited fashion because of a "pandemic" (of swine flu), which used a then-new and slightly experimental technique (adjuvants) which interestingly, German doctors flagged up as a risk and suggested the German government use a different H1N1 vaccine that was less experimental.

Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by adamjb on Monday November 09, 2020 @09:32AM (#25035167)
The 1976 Swine Flu outbreak and subsequent bungled vaccination campaign comes to mind
Re:Covid vaccine: First ‘milestone’ vaccine offers 90% prote... by aphextron on Monday November 09, 2020 @11:41AM (#25036596)
>The 1976 Swine Flu outbreak and subsequent bungled vaccination campaign comes to mind

Given that viral genome sequencing didn't even exist in 1976, I don't think it's a meaningful comparison.