Simply put: yes. Not just any thunderstorm. All thunderstorms.
All aircraft avoid thunderstorms. It's not a case of discomfort for humans inside it; it's about the risk to aircraft themselves.
Thunderstorms contain severe updrafts and downdrafts and huge windshear between them. Aircraft cannot outclimb the downdrafts so cannot maintain altitude inside them. And severe windshear will tear them apart.
The only reason you don't hear about aircraft lost in thunderstorms is because pilots avoid them. All of them.
If you get hit by the leading edge your plane will get smashed into the ground. If you somehow get to the back part, your plane might end up in the stratosphere, which might be just as fatal due to very low temperature and lack of oxygen.
He mentioned some early gliding pioneers who were insane and lucky enough managed to "ride" a thunderstorm and achieve record breaking flight distance - and somehow not getting killed in the process.
And then some. The forces in a run of the mill thunderstorm could rip the wings off a plane in seconds.
Storms are definitely regularly large enough to bring down even large aircraft, it doesn't happen often because planes of systems on board to ensure they avoid such weather, but it can happen!
You can't, but can a UAV? I'm curious how much more tolerant of bad weather a plane can be if there are no people inside. Are storms often strong enough to knock a plane out of the sky?