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Re:Genes, blood type tied to risk of severe Covid-19 by bobcostas55 on Thursday June 18, 2020 @02:16PM (#23565916)
GWAS studies typically use a p-value cutoff of 5*10^-8 to avoid exactly that problem.
Re:Genes, blood type tied to risk of severe Covid-19 by glofish on Thursday June 18, 2020 @02:31PM (#23566103)
p values cutoff can't salvage that

as a matter of fact artificially raising the cutoff to make the results sound more convincing is a form a p-hacking

it is exactly the opposite of how p-values work. a smaller p-value does not make a result more reliable, it makes no sense whatsoever to reject a 10^-7 but trust in 10^-8

the misuse of p-values in the world is rampant - the only people that don't misuse them are those that do not use them ;-)

Re:Genes, blood type tied to risk of severe Covid-19 by drocer88 on Thursday June 18, 2020 @02:41PM (#23566218)
See here: https://en.wikipedia.org/wiki/Genome-wide_significance

"The most commonly accepted threshold is p < 5 × 10−8, which is based on performing a Bonferroni correction for all the independent common SNPs across the human genome"

Re:Genes, blood type tied to risk of severe Covid-19 by zosima on Thursday June 18, 2020 @03:30PM (#23566822)
The reason for the low cutoff is to correct for multiple hypothesis testing.

Any what do you mean by "opposite of how p-values work"?

Obviously if P(data or more extreme|null hypothesis) = 10^-8 it's significantly less likely to see the data if the null hypothesis was true, than if P(data or more extreme| null hypothesis) = 10^-7.