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Re:Genes, blood type tied to risk of severe Covid-19 by rossdavidh on Thursday June 18, 2020 @12:50PM (#23564970)
My thoughts exactly. The article seemed to suggest that they looked at a truly ginormous number of SNP's, which suggests a high susceptibility to the xkcd "green M&M" type problem (https://xkcd.com/882/).

However, the good thing about blood type is that it should be reasonably easy/quick to do a followup where you examine a lot more patients, or even just randomly selected individuals, to see if it really holds up. As a type O person myself, I am hopeful.

Re:Genes, blood type tied to risk of severe Covid-19 by pjscott on Thursday June 18, 2020 @01:08PM (#23565182)
A GWAS will use significance criteria that correct for the millions of multiple comparisons. (This paper does.)
Re:Genes, blood type tied to risk of severe Covid-19 by bobcostas55 on Thursday June 18, 2020 @02:16PM (#23565916)
GWAS studies typically use a p-value cutoff of 5*10^-8 to avoid exactly that problem.
Re:Genes, blood type tied to risk of severe Covid-19 by glofish on Thursday June 18, 2020 @02:31PM (#23566103)
p values cutoff can't salvage that

as a matter of fact artificially raising the cutoff to make the results sound more convincing is a form a p-hacking

it is exactly the opposite of how p-values work. a smaller p-value does not make a result more reliable, it makes no sense whatsoever to reject a 10^-7 but trust in 10^-8

the misuse of p-values in the world is rampant - the only people that don't misuse them are those that do not use them ;-)

Re:Genes, blood type tied to risk of severe Covid-19 by drocer88 on Thursday June 18, 2020 @02:41PM (#23566218)
See here: https://en.wikipedia.org/wiki/Genome-wide_significance

"The most commonly accepted threshold is p < 5 × 10−8, which is based on performing a Bonferroni correction for all the independent common SNPs across the human genome"

Re:Genes, blood type tied to risk of severe Covid-19 by zosima on Thursday June 18, 2020 @03:30PM (#23566822)
The reason for the low cutoff is to correct for multiple hypothesis testing.

Any what do you mean by "opposite of how p-values work"?

Obviously if P(data or more extreme|null hypothesis) = 10^-8 it's significantly less likely to see the data if the null hypothesis was true, than if P(data or more extreme| null hypothesis) = 10^-7.

Re:Genes, blood type tied to risk of severe Covid-19 by drocer88 on Thursday June 18, 2020 @02:38PM (#23566179)
They used the "Global Screening Array (GSA), version 2.0 (Illumina), which contains 712,189 variants" [0]

[0] https://www.nejm.org/doi/full/10.1056/NEJMoa2020283?query=fe... "Genomewide Association Study of Severe Covid-19 with Respiratory Failure"