Re:Genes, blood type tied to risk of severe Covid-19
by drocer88 on Thursday June 18, 2020 @02:41PM
(#23566218)
See here: https://en.wikipedia.org/wiki/Genome-wide_significance
"The most commonly accepted threshold is p < 5 × 10−8, which is based on performing a Bonferroni correction for all the independent common SNPs across the human genome"
Re:Genes, blood type tied to risk of severe Covid-19
by zosima on Thursday June 18, 2020 @03:30PM
(#23566822)
The reason for the low cutoff is to correct for multiple hypothesis testing.
Any what do you mean by "opposite of how p-values work"?
Obviously if P(data or more extreme|null hypothesis) = 10^-8 it's significantly less likely to see the data if the null hypothesis was true, than if P(data or more extreme| null hypothesis) = 10^-7.
as a matter of fact artificially raising the cutoff to make the results sound more convincing is a form a p-hacking
it is exactly the opposite of how p-values work. a smaller p-value does not make a result more reliable, it makes no sense whatsoever to reject a 10^-7 but trust in 10^-8
the misuse of p-values in the world is rampant - the only people that don't misuse them are those that do not use them ;-)