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Re:Preliminary test results suggest 21% of NYC residents hav... by Karrot_Kream on Thursday April 23, 2020 @05:47PM (#22961907)
> Sure all of these studies are potentially flawed but they're all generally pointing in the same direction

That's unfortunately not the way statistics works. Combining multiple bad tests just makes the results incorrect or highly uncertain; the devil often is in the details. The Stanford/Santa Clara County study is a good example of how the details can really undermine a study.

Things do indeed seem to be converging to the idea that the CFR is not near the IFR, but none of this is new news, and the IFR remains very close to what most epidemiological predictions indicated early last month. If anything, it confirms that COVID is a difficult beast to tame.

Re:Preliminary test results suggest 21% of NYC residents hav... by TheBlight on Thursday April 23, 2020 @06:01PM (#22962062)
We don't have perfect studies and perfect data but calling these tests "bad" seems slightly unfair. They give us an imperfect but useful snapshot of what's going on. But thanks for the condescension. I'd expect nothing less on HN.
Re:Preliminary test results suggest 21% of NYC residents hav... by CydeWeys on Thursday April 23, 2020 @06:17PM (#22962201)
The study is dramatically over-sampling exactly the people who have the most potential exposure to COVID-19, and dramatically over-sampling the people who don't.

This could easily be way off. It's not testing the people who aren't home at all, and it has a low chance of only testing the people who leave home rarely, only when strictly necessary. It's mainly finding the people who leave home a lot.

Re:Preliminary test results suggest 21% of NYC residents hav... by varenc on Thursday April 23, 2020 @07:00PM (#22962580)
I think the overwhelming majority of people are visiting grocery stores to buy food. (Or have someone in their household doing it)

If the studied presume this then it makes more sense.

Re:Preliminary test results suggest 21% of NYC residents hav... by CydeWeys on Thursday April 23, 2020 @08:34PM (#22963329)
You can't assume that. I know plenty of people who haven't left their apartments in a month plus, because they're having groceries ordered in.

And you completely missed the point that people who are going outside a lot more often are both (a) more likely to have been exposed to COVID-19, and (b) more likely to be encountered by your survey. If there are e.g. 700 daily shoppers and 700 weekly shoppers going to a given store, then if you go on one day and sample every shopper you're not going to get half and half by population as you'd need to for a true random sample; instead, you're going to get 700 daily shoppers and only 100 weekly shoppers! This is a hugely biased sample!

Re:Preliminary test results suggest 21% of NYC residents hav... by cm2187 on Friday April 24, 2020 @04:43AM (#22965905)
The study wasn't one day but one week, and even then, I assume they wouldn't be stupid enough to collect blood from the same person over and over.
Re:Preliminary test results suggest 21% of NYC residents hav... by CydeWeys on Friday April 24, 2020 @12:27PM (#22969839)
There's more than one store in NYC. People shop at a variety of places. Daily shoppers are likely not going to the same store over and over every day. Even during this pandemic I've hit up several different grocery stores and shops, because some things are hard to find.
Re:Preliminary test results suggest 21% of NYC residents hav... by leereeves on Thursday April 23, 2020 @08:58PM (#22963497)
Are you describing the actual study or the study as you're imagining it? Because I imagine the statisticians have thought of these concerns and attempted to correct for them.

I find it interesting that this study corresponds to an IFR around 0.5%, similar to the IFR arrived at by other studies using very different methods. Perhaps the statisticians who conduct these studies actually know what they're doing better than Hacker News commenters.

And perhaps it's time to accept the politically inconvenient scientific truth these studies are revealing.

Re:Preliminary test results suggest 21% of NYC residents hav... by twomoretime on Friday April 24, 2020 @01:49AM (#22965056)
>similar to the IFR arrived at by other studies using very different methods

With the wild range of IFR from so many studies, you could trivially cherry pick supporting studies for a bunch of different numbers, especially if you throw in am error range.

Re:Preliminary test results suggest 21% of NYC residents hav... by wtvanhest on Friday April 24, 2020 @01:43AM (#22965028)
I’m starting to believe that the difference in opinions on whether these studies are legitimate or not hinges heavily on personal behavior.

For my wife and I and kid, we live in SF and order food when we can from grocery. When we can’t, I put on an N99 mask and gloves and buy 2 weeks worth of groceries. Then go through a ritual to be as safe as possible entering the home and bringing groceries in.

If someone asks me at the grocery store to take the covid test, no way. How would I even do that safely???

I live in San Francisco though and am worried about the fact that the grocery is 70% instacart workers.

Everyone I know in the city (nyc, sf, Boston, Chicago etc.) is trying to use 3rd parties to get their groceries.

Everyone I know in the suburbs is going to the store.

I believe the reason people read this study differently is that their experience is different. The whole foods in downtown sf would be scary to be in without a mask. And I view it as the riskiest place I have to go.

It’s full of gig workers who are taking way more risk than the average person.

We will know more when we see the results of the study, but I think we need a more random sample before thinking this NYC study is even remotely close to showing that 20% of NYCers previously had it

Re:Preliminary test results suggest 21% of NYC residents hav... by cm2187 on Friday April 24, 2020 @04:45AM (#22965917)
I'm afraid the population who has these options (and spends its time on hackernews) is called the 1% for a reason, and probably aren't going to bias the stats significantly.
Re:Preliminary test results suggest 21% of NYC residents hav... by CydeWeys on Friday April 24, 2020 @12:29PM (#22969876)
This doesn't make any sense. Grocery and food delivery is quite affordable. It's not only available to the top 1%. These options are being widely taken advantage of by a large number of people right now way down the economic spectrum. It's not a tiny minority of the wealthiest people patronizing them.
Re:Preliminary test results suggest 21% of NYC residents hav... by keenmaster on Saturday April 25, 2020 @02:06AM (#22976016)
At any given point of time, a disproportionate number of shoppers in a store are super-shoppers - people that shop more often than the average person and for longer periods of time. Those people are also more likely to have caught Coronavirus before. Without even getting into online ordering, false positives, etc...this phenomenon alone may confound the test results.
Re:Preliminary test results suggest 21% of NYC residents hav... by TheBlight on Thursday April 23, 2020 @06:36PM (#22962350)
How do you know how often these people are leaving their homes? Everyone has to leave their home to go to the grocery store eventually or someone in their family does. Yes there are delivery services but the vast majority of people aren't using those.
Re:Preliminary test results suggest 21% of NYC residents hav... by kgwgk on Thursday April 23, 2020 @06:48PM (#22962459)
The more often they go, the more likely you encounter them.
Re:Preliminary test results suggest 21% of NYC residents hav... by FlyMoreRockets on Thursday April 23, 2020 @07:19PM (#22962751)
True, but if you encounter one daily shopper, two weekly shoppers and twenty monthly shoppers, it will skew the results. Same if the numbers are reversed.
Re:Preliminary test results suggest 21% of NYC residents hav... by CydeWeys on Thursday April 23, 2020 @08:31PM (#22963315)
But you won't, the opposite will happen; you'll proportionally encounter way more daily shoppers than infrequent shoppers, for the simple tautological reason that the daily shoppers are going more often.

This is a sampling bias, and it's the exact same problem as if you ran a survey trying to ascertain how many people have landlines ... by calling random phone numbers.

Re:Preliminary test results suggest 21% of NYC residents hav... by kgwgk on Thursday April 23, 2020 @07:26PM (#22962817)
I don’t get your point. Maybe we agree. If in one city there are 1000 30-year-old daily-shopers, 1000 50-year-old weekly-shoppers and 1000 70-year-old monthly-shoppers it will not be a good idea to estimate the age of the population by sampling people who enters the store. The average age is 50, not 34.
Re:Preliminary test results suggest 21% of NYC residents hav... by jdavis703 on Thursday April 23, 2020 @08:03PM (#22963109)
Most people in NYC are almost certainly not shopping monthly because of storage constraints. Even bi-weekly shopping is likely to exhaust storage space for city-dwellers in small apartments.
Re:Preliminary test results suggest 21% of NYC residents hav... by akiselev on Thursday April 23, 2020 @09:33PM (#22963719)
Couldn't you get a bad study that reverses the sampling bias to get a decent picture of social distancing strategies using the two bad studies? That alone seems far more useful than knowing the IFR because its actionable information.
Re:Preliminary test results suggest 21% of NYC residents hav... by qqqwerty on Thursday April 23, 2020 @10:55PM (#22964186)
Or better yet, do a simple survey and ask the participants how frequently they go to the grocery store. And if you see a correlation between frequency and infection rate, then try and adjust your weights accordingly.

These bias issues are well known among survey designers. There are ways that you can try and account for them. It seems like maybe the medical community is too used to having control groups in their studies?

Re:Preliminary test results suggest 21% of NYC residents hav... by SubiculumCode on Friday April 24, 2020 @01:20AM (#22964908)
Most people go to the grocery store. There seems to be this attitude on HN of immediately dismissing research. No human research is ever perfect, flaws and limitations will always be present, and in the present case, study designs are being expedited in order to be timely. Each study is a piece, and together can provide convergent evidence.
Re:Preliminary test results suggest 21% of NYC residents hav... by capkutay on Thursday April 23, 2020 @10:53PM (#22964173)
OP's whole point is it's not a good sample because people were recruited while grocery shopping...I can't think of a more tech industry-oriented view of the world; most people work from home on zoom and use instacart right??

No. I'd expect people who order deliveries online and can do their entire job on Zoom/slack all day to be a minority to the point where including them in the study would be covered in a sampling error.

Re:Preliminary test results suggest 21% of NYC residents hav... by mlthoughts2018 on Thursday April 23, 2020 @11:37PM (#22964389)
You’re completely missing the point. The selection effects would be things like able-bodied / non-immunocompromised / already-recovered people being selected way higher, which would inflate the apparent infected population size estimate and underestimate the death rate among those infected.

This is not some snooty tech point of view - this kind of flaw in statistical studies matters a lot. The more important the policy implications are, the more important the validity of statistical methods.

It’s anything but parochial.

Re:Preliminary test results suggest 21% of NYC residents hav... by mlyle on Friday April 24, 2020 @01:01AM (#22964809)
I don't think anyone disagrees that the sample has bias. On the other hand, since the majority of people have no choice but to grocery shop in person, I do not think the sample is as tilted as you imply.

And even if it were--- it's notable that it's this easy to find a subgroup with cleared infections this far above what was anticipated to be found across NY/NYC.

And-- it's remarkably consistent with statistical estimates made through a variety of other means, e.g. https://www.medrxiv.org/content/10.1101/2020.04.18.20070821v...

Re:Preliminary test results suggest 21% of NYC residents hav... by mlthoughts2018 on Friday April 24, 2020 @08:34AM (#22967266)
> “ since the majority of people have no choice but to grocery shop in person”

This is deeply flawed.

I live in NYC and have been making donations to have food delivered to elderly people since this started.

Just the other day, de Blasio announced that taxi and rideshare drivers would be paid by the city to deliver food - and city agencies would be serving as overflow dispatchers and tech support for it.

Many, many people do not have to go to the grocery store, or they have their healthy younger family member go in their place, etc.

To boot, as Gelman has written on his blog, these studies do not agree with a wide range of other studies, and in most cases the test specificity is on par with the incidence rate itself, making incidence rate estimates from _all_ of the studies very unreliable for correlated reasons, so that pooling the studies does nothing to overcome the huge uncertainty they suffer in incidence rates.

Re:Preliminary test results suggest 21% of NYC residents hav... by mlyle on Friday April 24, 2020 @11:49AM (#22969294)
> and in most cases the test specificity is on par with the incidence rate itself,

????? We can't exclude that specificity may be 97% (it's unlikely, based on our data, but it's at the edge of the confidence interval), which is unfortunately on par with the studies returning 2-4% positives... but can't exactly explain a return of 21%. Subtract off 4% worst-case false positives from 21%, and where are you?

Since you want to appeal to authority with Gelman, this is what he said about this on his blog: "– Those California studies estimating 2% or 4% infection rate were hard to assess because of the false-positive problem: if a test has a false positive rate of 1% and you observe 1.5% positive tests, your estimate’s gonna be super noisy. But if 20% of the tests you observe are positive, then the false-positive rate is less of a big deal." ... "– In any case, the 20% number seems reasonable. It’s hard for me to imagine it’s a lot higher, and, given the number of deaths we’ve seen already, I guess it can’t be much lower either."

> so that pooling the studies does nothing to overcome the huge uncertainty they suffer in incidence rates.

The case count multiple from the serological study for New York state (and indeed, the California counties) is right in line with what's expected with a variety of statistical measures that were made without relying upon the serological data. So if you even peeked at my source you'd not be making this argument. https://www.medrxiv.org/content/10.1101/2020.04.18.20070821v...

Re:Preliminary test results suggest 21% of NYC residents hav... by mlthoughts2018 on Friday April 24, 2020 @10:43PM (#22975111)
From the same Gelman article:

> First off, 3% does not sound implausible. If they said 30%, I’d be skeptical, given how everyone’s been hiding out for awhile, but 3%, sure, maybe so.

Re:Preliminary test results suggest 21% of NYC residents hav... by SubiculumCode on Friday April 24, 2020 @01:28AM (#22964941)
This is a convenience sample no doubt, but convenience is important here, as timeliness is important. It is easy to naysay, but why don't you suggest a less biased convenience sample? Because unless you mandate whole population testing, samples will always be biased in some way. Those who have phones, those who have time, those who are motivated, etc etc. Given all the potential ways it could be biased, choosing a convenience sample at locations almost universally used is not bad at all, imo
Re:Preliminary test results suggest 21% of NYC residents hav... by np_tedious on Thursday April 23, 2020 @11:16PM (#22964280)
> Combining multiple bad tests just makes the results incorrect or highly uncertain

But it's not just, say, taking a bunch of faulty studies and average them and saying voila. They are in agreement. They'd have to be bad in similar ways in order to converge like that.

Re:Preliminary test results suggest 21% of NYC residents hav... by Mikeb85 on Friday April 24, 2020 @12:59PM (#22970311)
> That's unfortunately not the way statistics works.

It absolutely is. That's why we have things like confidence intervals.