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A comment on Sucralose with carbohydrates may blunt the body’s ability to metabolize sugar. Parent comment

Re:Sucralose with carbohydrates may blunt the body’s ability... by Spooky23 on Tuesday March 10, 2020 @11:28AM (#22536252)
Metformin is a pretty serious drug and that is a high dose. It's one thing to use it for off-label use like PCOS, but I would be very cautious for a more nebulous use.
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Re:Sucralose with carbohydrates may blunt the body’s ability... by toomuchtodo on Tuesday March 10, 2020 @11:39AM (#22536355)
Metformin is fairly safe and toxicity doesn't occur until you reach doses that are many, many times higher than therapeutic doses [1] [2]. Not a doctor, not your doctor, talk to your GP before starting such a regimen (especially for healthy kidney and liver function). My prescription was a 3 minute convo after my annual physical ("its safe, my kidneys and liver are working, I want to live longer [3] [4], and I will sign a waiver I won't hold you liable if necessary"), and I would've just ordered it online if my doctor said no.

[1] https://care.diabetesjournals.org/content/35/4/731

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934269/

[3] https://www.ncbi.nlm.nih.gov/pubmed/25041462

[4] https://clinicaltrials.gov/ct2/show/NCT02432287

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Re:Sucralose with carbohydrates may blunt the body’s ability... by trenning on Tuesday March 10, 2020 @12:10PM (#22536673)
What does metformin do for therapeutic purposes? wiki doesn't allude to much besides diabetes treatment.

https://en.wikipedia.org/wiki/Metformin

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Re:Sucralose with carbohydrates may blunt the body’s ability... by trenning on Tuesday March 10, 2020 @12:45PM (#22537041)
thanks I missed that section!
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Re:Sucralose with carbohydrates may blunt the body’s ability... by TylerE on Tuesday March 10, 2020 @02:36PM (#22538152)
Basically, the TLDR is that it makes the insulin your body produces work better.

The nice thing about it is that it can't drive your blood sugar low.

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Re:Sucralose with carbohydrates may blunt the body’s ability... by ketamine__ on Tuesday March 10, 2020 @11:53AM (#22536498)
Did you have diarrhea when you started Metformin?
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Re:Sucralose with carbohydrates may blunt the body’s ability... by toomuchtodo on Tuesday March 10, 2020 @11:54AM (#22536516)
None. Some people do, it is a documented side effect.
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Re:Sucralose with carbohydrates may blunt the body’s ability... by fredsanford on Tuesday March 10, 2020 @03:50PM (#22538915)
Not just diarrhea but this horrible greasy concoction that required a shower...

Metformin could be sold as an ultra laxative for some folks...

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Re:Sucralose with carbohydrates may blunt the body’s ability... by vonmoltke on Tuesday March 10, 2020 @01:58PM (#22537796)
> Metformin is a pretty serious drug and that is a high dose.

According to a former endocrinologist of mine, 1000mg daily is the lowest effective dose. 500mg pills are the lowest dose available. What is your source for 1000mg being a "high dose"?

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Re:Sucralose with carbohydrates may blunt the body’s ability... by Spooky23 on Wednesday March 11, 2020 @09:40AM (#22545713)
For diabetes or PCOS, sure.

What is the effective dose for general life extension?

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