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Re:Italy is extending its coronavirus quarantine measures to... by igravious on Monday March 09, 2020 @06:40PM (#22530690)
People keep extrapolating that tens of millions will die, and I don't doubt that tens of millions surely would _if_ there were no lock-downs! (The subject of this article!)

The whole point of locking down Wuhan/Hubei and then northern Italy and now the whole country and other places and cancelling large public gatherings and events is that local, regional, and national authorities start seeing the numbers soaring and initiate extreme mitigation strategies.

We don't know how successful these strategies will be individually/collectively in the long run but if China is anything to go by it can severely retard the spread of the virus.

To show I'm not spouting out of my derriere compare the logarithmic infection and death rates of China[1] and Italy[2]

So you have to modify your formula: `7.8 billion * 0.6 * 0.03 * mitigation_factor = ?` We just don't know what the mitigation_factor is yet and because the spread is exponential any dent in the rate of spread brings the fatality number tumbling down[3].

I happen to believe this virus is a very serious global threat and I assure you that I am not one given to alarmism. But I also have never seen governments respond to the onset of an epidemic like this before and I'm nearly fifty and my mother says she can't remember anything like this in her lifetime. So yes, tens of millions absolutely could die but I'm willing to bet that between lock-downs and modern medicine tens of millions won't and I pray to, you know, $deity I am not wrong.

[1] https://www.worldometers.info/coronavirus/country/china/

[2] https://www.worldometers.info/coronavirus/country/italy/

[3] https://www.youtube.com/watch?v=Kas0tIxDvrg [Exponential growth and epidemics]

Re:Italy is extending its coronavirus quarantine measures to... by adventured on Monday March 09, 2020 @07:19PM (#22531014)
There is cause for optimism in the numbers out of South Korea and China. Even assuming China has lied about their numbers (population ratios with Italy and South Korea vs China make that plainly clear, they lied to a large degree on the numbers), if China has managed to bring it under control through their extreme quarantine measures, then we can prevent it from killing tens of millions. South Korea seems to have considerably slowed it there. Japan has done a good job of limiting its spread.

China has 1.4 billion people, and they've had ~3,000 deaths (let's assume it's several times higher in reality). But we'll see tens of millions dead globally? No we will not. If you killed every person that has been infected in China, and extrapolated that event globally, we would not see tens of millions dead. So that premise is absurd, to an extreme.

I consider this to be a very serious situation, however, it's not very serious as a great mass mortality threat (unless it mutates and becomes far more deadly and we prove unable to slow it down or vaccinate against it). It's a serious threat for massive disruption to our daily lives, including severely harming the global economy. It's a serious threat to swamping our healthcare systems due to ICU demands and diverting our resources to managing the ongoing crisis (instead of routine, normal productive work).

Assuming this isn't going to burn out come Spring & Summer, the next step is to rush to vaccine, at any cost. That will end this thing globally. Maybe we'll need to vaccinate against it annually, maybe it won't come back after this year, who knows of course.

Tens of millions will not die. Tens of thousands might die in the plausible worst case scenario, before we get a vaccine ready. We can rush to vaccine at greater patient risk and financial cost, as necessary.

Re:Italy is extending its coronavirus quarantine measures to... by greedo on Monday March 09, 2020 @10:33PM (#22532241)
I think this is far too optimistic.

1. We don't know the actual reality of what's happening on the ground in China. Hubei and Italy have approximately the same population, yet Italy is suffering more proportionally. I think the obvious explanation is drastic underreporting of cases and fatalities in China. When all is said and done I think China probably has underreported by at least a magnitude if not double that.

2. Most Western countries won't impose the type of strategies that China undertook; they simply can't. When things get too bad to impose draconian quarantines, it'll be too late. Even Italy's efforts in quarantining the nation are not enough.

3. Most of the world doesn't have good healthcare. I'm talking about Africa, Southwest Asia, South America. There simply aren't enough ICU beds and ventilators to go around. Even in the US, I've read reports of only 100K ventilators nationwide. If the pandemic keeps growing exponentially with a doubling period of 4 days, the US alone will have 1M cases by mid-April.

4. Simple math. World population outside of China is 6.5B. If 10% are infected (very conservative imho) we're looking at 650M cases world wide. If the CFR drops to 1%, then we're in the neighborhood of 6.5m fatalities. And the survivors? Roughly 81% of those infected survive with no serious side effects. The remainder have serious health issues even after the disease runs its course. That's 117M casualties. This is world altering.

https://ourworldindata.org/coronavirus

Re:Italy is extending its coronavirus quarantine measures to... by igravious on Tuesday March 10, 2020 @07:03AM (#22534429)
And I think your assessment is too pessimistic.

To address (1.) You and others are going to have to provide sources for why you think that China "probably has under-reported by at least a magnitude if not double that". I've seen the ill feeling and distrust towards China increase on HN and elsewhere in the last 5 years and this fits the bill.

You can explain the differences between Hubei and Italy by the differences in responses. As has been pointed out, China built two make-shift hospitals in ~ 10 days and quarantined 100s of millions in cities. Have you not seen the pictures coming out of China. Now that Italy is taking drastic steps we'll see the outcome in a few weeks and it will tell us if it is an effective strategy. If any of the reported numbers is suspect it is the total number of cases that the USA is reporting: https://www.worldometers.info/coronavirus/ It's completely out of whack with every other country. This implies the US has been under-testing, something which we have lots of evidence for. On the other hand we have no evidence China is under-reporting.

To address (2.) "Most Western countries won't impose the type of strategies that China undertook; they simply can't." Why not? Why can't they?

To address (3.) "Most of the world doesn't have good healthcare." But most of the world has soap, most of the world understands what it means to self-isolate, most of the world can implement quarantining. "If the pandemic keeps growing exponentially with a doubling period of 4 days," Looks like mitigation strategies slow the doubling period to three weeks, why pick the worst case scenario?

To address (4.) "Simple math." Yes! Times an unknown mitigation factor of ? This outbreak is scary because it's exponential (highly lethal and highly infectious), but the total fatalities is also highly susceptible to interventions exactly for the same reason.

Re:Italy is extending its coronavirus quarantine measures to... by greedo on Tuesday March 10, 2020 @09:36AM (#22535308)
Chinese underreporting is currently underestimated by a factor of 20:(https://www.medrxiv.org/content/10.1101/2020.01.23.20018549v...)

I have no ill feeling towards China other than the fact that they have a repressive, authoritarian government. Those types of government necessarily try to control and spin the news to maintain their authority. If a country is willing to censor Winnie the Pooh to make their leader feel better, than they'll naturally minimize the effect of SARS-Cov2.

I also agree that the US is underreporting due to inadequate testing. Estimates in the US should be closer to 9-10K. I think that we'll see a large spike in cases as soon as testing approaches levels in other countries.

My inclination regarding quarantine controls in Western countries stems from the willingness of these societies to restrict freedoms. Italy's quarantine is very basic, a 1 on a 1-10 level. Compared to what China implemented, it's not even close.

Soap isn't the ability to treat cases; it's a way of trying to mitigate the spread.

Re:Italy is extending its coronavirus quarantine measures to... by cma on Monday March 09, 2020 @11:10PM (#22532420)
The region in Italy has something like 3x more elderly, proportionately, than Wuhan.
Re:Italy is extending its coronavirus quarantine measures to... by igravious on Monday March 09, 2020 @08:07PM (#22531356)
Thoughtful and level-headed response. :)

We might ballpark the number of global deaths – in the optimistic case† at between 20,000 and 30,000 souls. Not a global tragedy, on a scale of the recent Ebola outbreak, but warranting much more drastic action.

There's a huge sense of urgency. We could have a vaccine before the next flu season in the northern hemisphere.

† assuming not every country acts quickly when the time comes nor acts as effectively as China

Re:Italy is extending its coronavirus quarantine measures to... by airstrike on Tuesday March 10, 2020 @12:51PM (#22537095)
> We could have a vaccine before the next flu season in the northern hemisphere.

That's quite unlikely. We're looking at 12-18 months if everything goes perfectly according to plan and we get it right on the first try.

> nor acts as effectively as China

Only if you take China's numbers at face value, which nobody really seems keen on doing.

Re:Italy is extending its coronavirus quarantine measures to... by jpster on Monday March 09, 2020 @07:25PM (#22531051)
I’m not sure about the overall efficacy of lockdowns unless:

- The US plays along. We are likely a hotspot now, whether we go the “undertest and live in ignorance” route, or not.

- We have an effective plan for rebooting out of the lockdown. Which, until we have an effective treatment or vaccine, to me means temperature scanning in most public places imaginable, continued vigilance around disinfecting, continued limits on public gatherings, and more.

Re:Italy is extending its coronavirus quarantine measures to... by igravious on Monday March 09, 2020 @08:01PM (#22531314)
From what the numbers are saying it looks like the USA is both under-testing and over-reporting simultaneously. Very odd state of affairs. I'm ignoring the total cases number from the USA at present because it is a clear outlier. The # of deaths is much more reliable but that number will lag as tests are performed.

(The # of deaths for Germany is suspiciously low, as is the # of deaths for S. Korea.) I actually think the Chinese data is fairly accurate. the Iranian data, well, who knows. I'd like to think the European data is reliable, but again, who knows.

If the USA becomes a hot-spot then other countries will undoubtedly institute a travel ban to/from there like is happening with parts of China, S. Korea, Italy, Iran, and so on.

Re:Italy is extending its coronavirus quarantine measures to... by senordevnyc on Monday March 09, 2020 @07:12PM (#22530959)
This is impossible to contain. The purpose of the lockdown isn't to contain, it's just to spread out the infections over a larger period of time so that hospitals don't get overwhelmed. But there's likely not a plausible scenario at this point where we globally jump on this and only a few million or even tens of millions are infected. All we can do is slow it down.
Re:Italy is extending its coronavirus quarantine measures to... by igravious on Monday March 09, 2020 @07:51PM (#22531253)
China has demonstrated that it is in fact possible to contain the spread. Please use the links I provided to review the data. Do remember that the Chinese built two make-shift hospitals in something like 10 days. Once a couple of weeks pass we'll see if Italy is able to replicate what China did.

Here are my calculations based on current data[1]:

   Country     tot. deaths    pop. (1m)   tot. deaths/1m pop.
   Italy        463             62        7.46
   Iran         237             83        2.85
   China       3120           1384        2.25
   South Korea   53             51        1.03
   Spain         30             49        0.61
   France        30             67        0.44
   USA           26            329        0.08
Italy has blown past China which is why they've locked down the country. Iran will surely do so next if they are not already doing so unless they want a national calamity. South Korea reacted quicker. Spain, France, will have to act next, possibly next week or the week after, the USA will have to act in about 3 or 4 weeks assuming things remain the same but by that time it'll be early April and the weather will be getting warmer so who knows.

[1] https://www.worldometers.info/coronavirus/

Re:Italy is extending its coronavirus quarantine measures to... by senordevnyc on Monday March 09, 2020 @10:05PM (#22532095)
China’s current status is impressive but it’s come at enormous cost which is unsustainable in the long run. And it’s unclear what’s going to happen in the long run as China opens up workplaces and public gatherings, and as international travel and commerce resumes. It may very well explode again. Some countries will get a handle on this for now, but many won’t, and it will continue to spread globally. It might take months, it might take years, but it’s not going away.
Re:Italy is extending its coronavirus quarantine measures to... by igravious on Tuesday March 10, 2020 @07:09AM (#22534441)
People can do great things when needed. Who says it is unsustainable? Can we not change our habits? Can we not provide the equipment and supplies (respirators, medicines, masks, disinfectant and sanitizers) that need providing?

With any luck we'll have a vaccine in 18 to 24 months. The flu season is halted by warmer weather. We can change our behaviour for a few years until we get it under control.