Coronavirus Spike Protein Binder Design

Re:Coronavirus Spike Protein Binder Design by amelius on Tuesday March 03, 2020 @05:29AM (#22473300)

If you find a protein that blocks the virus, how difficult would it be to find a drug delivery mechanism that is capable of reaching all the important cells?

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Re:Coronavirus Spike Protein Binder Design by pas on Tuesday March 03, 2020 @05:38AM (#22473331)

Isn't blood pretty good at this?

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Re:Coronavirus Spike Protein Binder Design by amelius on Tuesday March 03, 2020 @06:58AM (#22473676)

I'm not a biologist but I suppose that not every kind of protein enters any kind of cell.

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Re:Coronavirus Spike Protein Binder Design by sp332 on Tuesday March 03, 2020 @11:09AM (#22475690)

You need these proteins to interfere with viruses before they enter cells, so that part is probably fine.

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Re:Coronavirus Spike Protein Binder Design by pas on Tuesday March 03, 2020 @12:35PM (#22476701)

Where the virus can go the antiviral can go too (because it's much smaller, only targeting a smaller protein spike on the surface of the viral envelope).

https://en.wikipedia.org/wiki/Coronavirus#/media/File:3D_med... [the N protein is supposedly the nucleocapsid, which is basically/maybe another envelope around the RNA]

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Re:Coronavirus Spike Protein Binder Design by hkt on Tuesday March 03, 2020 @06:43AM (#22473606)

Only if you want to deliver indiscriminantly

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Re:Coronavirus Spike Protein Binder Design by Gravityloss on Tuesday March 03, 2020 @06:47AM (#22473626)

A lozenge? A nose spray?

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Re:Coronavirus Spike Protein Binder Design by rolph on Tuesday March 03, 2020 @11:22AM (#22475869)

yes that is workable but a nebulizer is what is currently being proposed.

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Re:Coronavirus Spike Protein Binder Design by hammock on Tuesday March 03, 2020 @10:51AM (#22475471)

Typically such a protein would be delivered via infusion (IV), I believe.

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Re:Coronavirus Spike Protein Binder Design by rolph on Tuesday March 03, 2020 @11:21AM (#22475836)

the main trophic target of this virus is lung tissue. a nebulizer would deliver the mRNA-Fc complex to the lung tissue.

the other way around would look a lot like a classic vaccine delivered by injection, and encapsulate the mRNA into a vesicle that targets antigen presenting cells in the lymphatic system which then presents the mRNA product as an antigen-MHC complex to specify what antibody to generate.

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Re:Coronavirus Spike Protein Binder Design by hammock on Tuesday March 03, 2020 @12:17PM (#22476492)

Deliver mRNA, or a protein?

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Re:Coronavirus Spike Protein Binder Design by rolph on Tuesday March 03, 2020 @12:19PM (#22476506)

both or either dependent on the therapeutic strategy.

this is also something that is not limited to corona virus, this is the basis of a recombinant vaccine that can be adjusted for any antigen.

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Re:Coronavirus Spike Protein Binder Design by hammock on Tuesday March 03, 2020 @01:00PM (#22476998)

Cool. I was thinking about immunotherapy like IL proteins.. sometimes they are injected and sometimes infused, I don't know why.

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Re:Coronavirus Spike Protein Binder Design by rolph on Tuesday March 03, 2020 @01:18PM (#22477193)

it depends on the targets distribution, is it diffuse in the body or is it localized to a certain tissue type.

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