Re:Coronavirus Spike Protein Binder Design
by hammock on Tuesday March 03, 2020 @10:51AM
(#22475471)
Typically such a protein would be delivered via infusion (IV), I believe.
[ Parent
| on HN ]
the main trophic target of this virus is lung tissue.
a nebulizer would deliver the mRNA-Fc complex to the lung tissue.
the other way around would look a lot like a classic vaccine delivered by injection, and encapsulate the mRNA into a vesicle that targets antigen presenting cells in the lymphatic system which then presents the mRNA product as an antigen-MHC complex to specify what antibody to generate.
Re:Coronavirus Spike Protein Binder Design
by hammock on Tuesday March 03, 2020 @12:17PM
(#22476492)
Deliver mRNA, or a protein?
both or either dependent on the therapeutic strategy.
this is also something that is not limited to corona virus, this is the basis of a recombinant vaccine that can be adjusted for any antigen.