JAMF uses the MDM APIs that Apple provides. It also can't access personal data via those APIs. Your anti-virus may use kernel extensions, in which case it will stop working.
Probably, "die." I'm not sure we'll miss them; that whole market is sketchy, and more obsolete every year as the OS gets more secure on its own.
I would like to know what is the alternative today, not 10 years from now.
1. My parents lost money in the Internet. They treat scam messages ("you've been hacked, we have discriminating stuff against you, give us bitcoins and we don't tell anyone") seriously. They wanted to buy some wonder drug that didn't even exist. Now they contact me in every case that involves money on the Internet, and since several years there were a few other cases where I had to say "don't do it, this is a scam". So I'm effectively performing the role of a human thirdparty AV.
2. My girlfriend has been hit with a clickjacking compaign. She was crushed; I want to lessen the chance of this happening ever again. I've also educated her about it and how it works, so she will probably not do it anymore, but in the scale of whole humanity, the "let's teach them how to defend" is not a good strategy for trying to eliminate some harmful event, there will always be people that will resist learning.
3. I want to help with limiting spreading malware. If I'm using AV, this means that I influence the environment I live in so that everyone sees lower malware spread. This means people like you can wonder what is the point in AV tools, since you probably don't know even 1 person that had been hit with malware attack. Similar to vaccines I guess.
Also, do you mean XProtect? https://eforensicsmag.com/72717-2/
It's been really worrying to see large enterprises that have moved from Windows to macOS and carry their thinking that the need to install a third party AV product (which in turn often acts as a near-unrestricted way into the kernel).