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Re:12,000 Requests per second with Nginx, PHP and Memcached by 2mur on Tuesday February 15, 2011 @11:53AM (#2221980)
You should at least try nginx/gunicorn (http://gunicorn.org/). And if your clients are constantly pinging and the data hasn't changed, make sure you are caching it in memcache (etc) to relieve the database.

http://ericholscher.com/blog/2010/aug/16/lessons-learned-das...

Re:12,000 Requests per second with Nginx, PHP and Memcached by edanm on Tuesday February 15, 2011 @12:04PM (#2222043)
Honestly, I'm a little scared of using something like gunicorn. I could be wrong, but it seems like an extremely new technology, especially when compared to Apache, which has a lot of history behind it.
Re:12,000 Requests per second with Nginx, PHP and Memcached by antihero on Tuesday February 15, 2011 @11:59PM (#2225075)
You can have a failover, so if one breaks you can quickly boot the apache one back up.