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Re:New drug offers hope to those with severe migraines by xab9 on Friday May 18, 2018 @01:29AM (#17098951)
To me paracetamol works. Or at least worked, until I got addicted, so we're trying to switch to apranax, which acts terribly slowly (plus we added divascan as a generic migraine reducer).

Now I'm at the point where doctors are telling me to avoid pain relief pills so four days out of seven are usually just shit. Makes life harder then it should be.

Re:New drug offers hope to those with severe migraines by _acme on Friday May 18, 2018 @05:10AM (#17099851)
You got addicted to Tylenol? Could you be more specific? Do you just mean that it stopped working for you? Because if you mean you truly developed a compulsive desire to take APAP, you must be the first person in the world ever to have done so.
Re:New drug offers hope to those with severe migraines by aiCeivi9 on Friday May 18, 2018 @06:10AM (#17100179)
It is possible to be addicted to anything and it is quite easy with any painkillers, it doesn't have to opioid based one. Subconscious fear of pain is enough to take them in advance, just in case, every day.
Re:New drug offers hope to those with severe migraines by xab9 on Friday May 18, 2018 @01:44PM (#17103395)
No no, not in advance, but when I could claw my eyes out because of the pain - the problem was that slowly, year after year it worked less and less.
Re:New drug offers hope to those with severe migraines by facetube on Friday May 18, 2018 @07:10AM (#17100449)
APAP metabolizes to AM404 in vivo, which acts indirectly on the cannabinoid receptor type 1. AM404 is likely responsible for a large amount of the pain relief (and, unsurprisingly, an anticonvulsant effect).

I suspect it's tolerance and not addiction, but docs see this and code it as "medication overuse headache" all the time.

Re:New drug offers hope to those with severe migraines by xab9 on Friday May 18, 2018 @01:43PM (#17103382)
Saridon but all the same I guess. Not my wording though, but the doctor's.