Re:Coronary heart disease is a chronic inflammatory condition
by tim333 on Monday March 12, 2018 @06:20AM
(#16567151)
The mechanisms of cholesterol -> heart disease are not well understood. Cholesterol is a natural component of the blood - if it's too low or high it implies you are ill. The levels being off correlate with heart disease but I don't think there's a simple high cholesterol directly causes deposits causation.
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Re:Coronary heart disease is a chronic inflammatory condition
by Gibbon1 on Monday March 12, 2018 @10:57PM
(#16573613)
What would bother me is the idea of two stories
Story one:
High cholesterol --> higher rates of plaque deposition -> heart disease.
Story two:
Inflammation --> plaque deposition that is highly sensitive to cholesterol levels --> heart disease.
No Inflammation --> no plaque deposition --> no heart disease.
If story one is true, inflammation is unimportant. If story two is true then inflammation is what's important and going after cholesterol levels is treating a secondary cause instead of the primary cause. One gets fooled by the dose/disease relationship in the context of inflammation.