Re:Coronary heart disease is a chronic inflammatory condition
by Gibbon1 on Monday March 12, 2018 @10:57PM
(#16573613)
What would bother me is the idea of two stories
Story one:
High cholesterol --> higher rates of plaque deposition -> heart disease.
Story two:
Inflammation --> plaque deposition that is highly sensitive to cholesterol levels --> heart disease.
No Inflammation --> no plaque deposition --> no heart disease.
If story one is true, inflammation is unimportant. If story two is true then inflammation is what's important and going after cholesterol levels is treating a secondary cause instead of the primary cause. One gets fooled by the dose/disease relationship in the context of inflammation.
Story one:
High cholesterol --> higher rates of plaque deposition -> heart disease.
Story two:
Inflammation --> plaque deposition that is highly sensitive to cholesterol levels --> heart disease.
No Inflammation --> no plaque deposition --> no heart disease.
If story one is true, inflammation is unimportant. If story two is true then inflammation is what's important and going after cholesterol levels is treating a secondary cause instead of the primary cause. One gets fooled by the dose/disease relationship in the context of inflammation.