I have had over 500GB syncing on OneDrive before via an office 365 account. It was fine. It would crash or mess up a lot more in early 2016 and 2015. But has been pretty good in the past year.
OneDrive still has issues though.
It doesn't understand symlinks and it doesn't allow far too many special characters in file names.
MS fanboy remark seems weird. I'm guessing you'll just think I'm an MS fanboy. Which would be silly, I use Apple products far more among other companies. OneDrive might actually be the only Microsoft app I use consistently.
Normal OneDrive which is what comes with the $80/year/5 people Office 365 isn't perfect. A few issues/features that they should have finished by now, but I'd be really surprised if regular OneDrive was causing those amt of issues.