I'd imagine the main issue is VSTs.

Some VSTs work flawlessly, others can be problematic and others do not work at all. You need to check them one by one, but surely a lot of them work. (edit): VSTs incompatibility doesn't just affect WINE but Windows itself from version to version. If you take a look at Reaper (reaper.fm), it has some options to run VSTs in various compatibility modes. This paired with WINE's ability to fake a different Windows version "emulation" should help with more problematic VSTs.

There are some VST bridge programs that use WINE underneath. I haven't actually used any yet so I can't attest to their usefulness.

https://github.com/abique/vst-bridge https://github.com/phantom-code/airwave

I don't actually use too many VSTs. I can generally make everything I need to make with the built in plug ins

I really want to start using bitwig (it seems like Ableton, but better), but I can't afford it. In all honesty, I'm using a cracked version of Ableton that I found man years ago, but I can't really find (or securely test) bitwig cracks.