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Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by larrys on Sunday September 20, 2015 @03:17PM (#10248648)
While shocking people have to keep in mind that pricing relates to more than cost but more importantly value. The fact that a particular product or service was priced a certain way for years is not as relevant as it might seem on the surface. I pay a very low price for a generic drug (copay doesn't even matter) but the value to me of the drug is much higher. The non generic version is priced perhaps 10 times as much but still provides value at that price. Perhaps these prices in the article are super inflated but my point is the fact that a drug was priced at $5 per tablet and now is $50 per tablet is not a non-starter in itself. Who cares what the % increase is? The question is does the drug provide value at $50 per tablet? Also a particular person's ability to pay doesn't really factor into this. I am sure the drug companies would love to be able to charge some classes of people more (Larry Ellison) and some less (jobless). But they are not allowed to do this. I know people's automatically will think "ripoff" (and maybe it is a "ripoff" whatever that is) however a price increase in itself does not indicate a ripoff.

"Cycloserine, a drug used to treat dangerous multidrug-resistant tuberculosis, was just increased in price to $10,800 for 30 pills from $500 "

Right and I don't take any drugs that even cost $500 for 30 pills (let alone $10,800). So this article could have just easily compared the pills that I buy 30 for $10 to 30 for $500 and written a similar article.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by powera on Sunday September 20, 2015 @03:29PM (#10248694)
No, unless you feel that people who use medicine are nothing more than a resource to be exploited.

Were it not for a (probably illegal in this case) monopoly, other people would be able to make that same pill for $5 per tablet. And then nobody would pay $50 for the pill.

Supply and demand IS NOT the same as "charging everyone as much as they will pay for everything". It's inherently unfair to everyone who has to buy that thing, and that's why people think it's a rip-off, because it is.

[edited to remove some hyperbole]

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @04:01PM (#10248817)
The question is, if it costs me X to make a product, and the value to you is 100X, who captures the 99X spread? I could charge 99X, you would pay it since the value is higher, and I'll capture most of it. I could charge 2X, it's still worth it to me to produce it, and you'll capture most of it. What value here is most fair? Why is one value fairer than another? The standard economic answer is "let the market decide", and that works, up to a point. If you reject that, you need a better way to decide. Let's say you have a government agency set prices: how do they choose?

You've just pushed the problem around. Saying "get rid of the free market" in only a solution if you have a concrete alternative.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by powera on Sunday September 20, 2015 @04:04PM (#10248835)
I'm not saying "get rid of the free market". I'm saying that in a monopoly situation, there is no free market. And if there is no free market, claiming "the free market will work" is insanity, so we have no choice but to try something else.
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @04:10PM (#10248873)
What is that something else?

In a monopoly situation, the price tends towards 100X in my example, which is still less than the value provided. Even in a monopoly, nobody's paying more for a product than they receive value from it.

Yes, it may still seem unfair, but what else are you proposing? Nobody should sell the product? How is that making anyone better off?

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ohazi on Sunday September 20, 2015 @04:50PM (#10249053)
"Something else" is removing the artificial constraints that created the monopoly in the first place.
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @06:40PM (#10249476)
What artificial constraints are those?
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ohazi on Sunday September 20, 2015 @04:45PM (#10249027)
"Letting the market decide" requires you to actually have a market. If you have a market of manufacturers that all produce a product for around X, then it doesn't matter if I value the product at 100X or 1,000,000X. I'm still going to be paying around X + epsilon. That's the entire point of having a market.

You only see people asking questions about "well, who captures the extra value? what's fair?" etc when you don't have a market. When you actually have a market, then these questions cease to be relevant, because the price is already set.

The problem has nothing to do with free market concepts breaking down, or disagreements about what's fair. The problem is that we've artificially prevented this market from existing. Fix that and the problem goes away.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by pxndx on Sunday September 20, 2015 @04:05PM (#10248839)
The thing is, the value for these products is infinite. If people don't have them, they'll die.
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @04:08PM (#10248858)
The value of a human life is not infinite, at least not in health budgets. Insurance companies set a non-infinite value to decide what procedures to cover.

In theory, you could calculate the exact value provided by this drug (under the QALY model).

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by learc83 on Sunday September 20, 2015 @04:39PM (#10249000)
The value of a human life to the individual who's life it belongs cannot be calculated in economic terms (at least for most people) because it is unbounded, i.e., there is not a price that most people will accept for their life. The economic value of a human life to society can be calculated.

Under your theory a fair method to price life saving drugs doesn't exist. The person getting the drugs will effectively extract infinite value while the company will only extract a finite value.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by icebraining on Sunday September 20, 2015 @05:32PM (#10249226)
The value of a human life to the individual who's life it belongs cannot be calculated in economic terms (at least for most people) because it is unbounded, i.e., there is not a price that most people will accept for their life.

Not really true, I'm afraid. People killing themselves (or allowing others to kill them) to ensure a payout to their families happens with some regularity.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by learc83 on Sunday September 20, 2015 @06:03PM (#10249351)
1. My qualifier "most people" covers that situation, because it is very very rare.

2. Usually this happens because they place a higher value on their children's life and well being than their own. So even in the case were someone does place a value on their own life, it's only in relation to someone else's life.

The case of 2 is interesting because it shows that of the people who would accept a finite sum for their own life, very few would accept a finite sum for their chidren's life.

Since paying for the child's healthcare is the responsibility of the parent in a free market, we are back to my previous point that their is no fair free market way to price life saving drugs.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by randyrand on Sunday September 20, 2015 @05:25PM (#10249195)
NOT TRUE! Sometime's it's the opposite. My grandfather routinely denies spending money on himself (medical or otherwise) since he won't be around much longer. He would rather have the money stay for his kids. He feels this way even about procedures that would save his life.
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by username223 on Sunday September 20, 2015 @06:21PM (#10249401)
You're the guy who won't save the drowning child because your suit would get dirty, right? No, wait, you'd ask the kid if she would pay to have it dry-cleaned, then still refuse because you could probably get her to pay even more.
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @06:43PM (#10249488)
What does that have to do with anything?

Who is worse: the person who doesn't save the child, or the person who saves the child, and sends a bill later?

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by qsucvatz on Sunday September 20, 2015 @03:43PM (#10248745)
Quite an opener, do you practice hyperbole often?

Fairness is whatever two people will agree to pay for a service.

Imagine how silly it would be if we all paid the same amount for seats on an airline - which is how it worked before deregulation. Many seats would go empty, the utility would not be maximized, and we'd be missing out on the great transfer of wealth from the rich to the poor.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by powera on Sunday September 20, 2015 @03:48PM (#10248765)
And everybody also generally hates the airlines and feels the pricing is unfair because of this.

You might say that without it airplanes would not fly at all, and you might be right. But it's incredulous to claim that without these profits the medicine would not exist at all; it has existed already for 5 decades. (And we have patents as a system specifically designed to allow for funding the creation of drugs)

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by gdrulia on Sunday September 20, 2015 @03:51PM (#10248782)
What you're saying makes perfect sense on paper, but unfortunately reality is as always slightly more complex.

Such simple thinking is full of the holes for exploitation and there will always be someone who will exploit them. Medicine is especially sensitive, because medicine can be priceless in value for the human who needs it, but that same human might not be able to pay that much. You can introduce government help, but if such exploitation is allowed, it would simply end up in a waste of tax money.

One thing is to allow companies who invest into products creation to receive the profit from it by using monopoly and charging as much as they like, and completely another is buying the company and starting to charge many times higher for the medicine that was available for years.

This might not be a popular view, but I can see no reason to think that such an exploitation should be tolerated. I simply cannot see how such things benefit humans as a society. I might be missing here something and if I do, please let me know.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @04:04PM (#10248833)
The question is how we can fix this systematically without making bigger problems. Should a government agency set prices? What if the company stops making the drug, then? The price is high because no other companies are willing to make it for lower, after all. Note that the drug in question is not under patent.

I don't think you'd advocate for literally forcing the company to make it and sell it for a specific price.

There's also the concerns I went over here: https://news.ycombinator.com/item?id=10248817

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by pixl97 on Sunday September 20, 2015 @04:31PM (#10248952)
>What if the company stops making the drug, then? The price is high because no other companies are willing to make it for lower, after all.

Nope, don't force the company to make it. Force the company to give the formulation to another company that will. This article states the reason it is able to be priced so high, at least for a time, is that other companies will have to reverse engineer it and get a line running. Take out the time of getting the product formulated right and the original holder has to think about the ramifications of any shenanigans they will attempt to pull.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @05:01PM (#10249105)
The composition is public, and needs to be disclosed when patented. In order to get FDA approval for a generic drug, you need to show that it performs as well as the actual drug (not really, but that's a different issue [0]). In order to do that, you need to have samples of the actual drug.

[0] http://fortune.com/2013/01/10/are-generics-really-the-same-a...

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by adwf on Sunday September 20, 2015 @04:36PM (#10248983)
Government setting prices works for the NHS in the UK. If a drug is too expensive it just doesn't get authorised as a treatment and we go with something else. The collective bargaining power of the nationalised system effectively forces the pharmaceutical companies to the table everytime. They'd rather sell for some profit than no profit.

It's only because the pharma companies can deal with consumers in the US on an individual basis that you guys get screwed over so much on your pricing.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by refurb on Sunday September 20, 2015 @05:38PM (#10249248)
It's only because the pharma companies can deal with consumers in the US on an individual basis that you guys get screwed over so much on your pricing.

That's not true at all. The biggest private insurance companies in the US are what? 30-40M lives? That's bigger than Canada. They routinely negotiate for lower drug prices.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @06:37PM (#10249459)
If the proposal is "set up a single payer system in the US", this may be relevant.

Do you know where I could find out whether the NHS is covering Daraprim at the new prices?

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by darklajid on Sunday September 20, 2015 @06:28PM (#10249425)
I'm confused. The article is about a drug that was sold at price X (13.5) that is now offered at price Y (750).

Now, in my world every rational person has to see that this is insane. There's no way that the previous price was even remotely possible (even with a loss) that requires the new price.

I don't see any data that supports your 'no one would be willing to make it for less' argument. The only reasons that doesn't seem to happen are either technical (the monopoly on the drugs manufacturing process) or legal (can't do that or you have to pay for .. creating cheaper drugs). Can you back your unlikely scenario? Looking at the article in question, is 750 the 'right' price and no one's willing to create the drug for less? Were they losing about 700 a pop before they increased the price?

What. The. Hell?

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @06:33PM (#10249445)
I don't see any data that supports your 'no one would be willing to make it for less' argument.

There are currently no other companies that are willing to make and sell the drug.

* The only reasons that doesn't seem to happen are either technical (the monopoly on the drugs manufacturing process) or legal (can't do that or you have to pay for .. creating cheaper drugs).*

The patent is expired, and saying "monopoly" is describing an outcome, not an input. Yes, it's a monopoly, because no other company is willing to go into that market right now.

Looking at the article in question, is 750 the 'right' price and no one's willing to create the drug for less?

I would deny that any price is "right". If you want to refer to "right", define it and give a way to calculate what price can be right.

As I said in the other comment, there's no good system to determine who should capture the value from a product that costs less to make than it's worth to purchasers, other than a free market.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by darklajid on Sunday September 20, 2015 @07:45PM (#10249664)
Let's take this apart. I'm not an expert, not on drug creation nor on .. 'free market' theories.

1) I'm not convinced that no one is interested to create the drug. Numerous people in this very discussion list issues to create a 'replacement' drug, even if the patent is expired. If they are correct (see disclaimer above) that might be a reason why others haven't tried it - or why they haven't succeeded yet.

2) 'Right' price is ambiguous, I agree. In my world, drug prices are ethic problems and have no connection to the so-called free market. No, a working, helping, proven drug cannot cost hundreds of $currency. We can discuss about the need to offset the R&D costs and I'm fine with drugs that costs my health insurance a ~largish~ sum, as long as the end user can get instant and easy access to the drug.

Your comments about putting a price on a person's life and your opinions on drug prices - as far as I can follow! - are impossible to understand from this person's pov. The lack of empathy and the trust in random business/market theoretical stuff to find a reasonable solution for the access to drugs that might very well save lives - that just doesn't compute, doesn't make sense in my world.

I don't believe in free markets. I certainly don't believe in free markets when we're talking about the basic needs of each and every human (for the sake of the argument let's limit this to nutrition and health for now). Health care should be free. Drugs should be affordable. Changing the price of a drug that was obviously doing okay (it was on the 'free market', right?) and multiplying the price by 65, because .. why not? .. is immoral and should be illegal. There's no 'value' to 'capture'. We're talking about a product that the company obviously produced with some sort of margin for ~13.5~ and that benefits the population at large - or at least the subset of the population that requires the drug. There is _no_ reason to increase the price, especially by that ridiculous value, other than inhuman greed. But maybe (see disclaimer) that's what a 'free market' is about - I wouldn't know.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @08:12PM (#10249723)
Numerous people in this very discussion list issues to create a 'replacement' drug, even if the patent is expired. If they are correct (see disclaimer above) that might be a reason why others haven't tried it - or why they haven't succeeded yet.

Replace interested with "no one is interested and able". The reasons don't matter (insofar as they cannot be changed), the fact is that no one else is making them.

The lack of empathy and the trust in random business/market theoretical stuff to find a reasonable solution for the access to drugs that might very well save lives - that just doesn't compute, doesn't make sense in my world.

This doesn't come from a lack of empathy. I am (or try to emulate) a utilitarianist. To my mind, the question to ask is "which system will produce better outcomes overall"?

As I've said elsewhere in this thread, this particular example has them covering the cost of the drug for anyone who can't afford it; so the value of a life is irrelevant. The question is "is it better for a health insurance company or the drug manufacturer to have the money?" This doesn't seem obvious.

On the other hand, any claims of "fairness" fail to compute. If doing X improves the world, who cares if it makes things less fair?

Health care should be free.

The world should be perfect. I agree. Now, do you have any way of bringing the world to perfection? Saying "Health care should be free" while ignoring the fact that currently, health care needs to be rationed, does nobody any good.

Who pays for health care, if it's free? Who becomes a doctor, a researcher, if the prices are driven down by politicians with similar arguments to yours?

There's no 'value' to 'capture'.

That sounds to me like saying that every drug company should be selling at cost or close to cost. The problem with that is that there's then much less incentive for investors to fund pharmaceutical startups, which leads to less new drugs being developed, and so on.

You can't ignore economics when building your utopia.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by toomuchtodo on Sunday September 20, 2015 @04:28PM (#10248938)
> Should a government agency set prices?

Yes.

> What if the company stops making the drug, then?

A non-profit government sponsored entity manufactures the drug at cost.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by randyrand on Sunday September 20, 2015 @05:29PM (#10249217)
The only way to properly do this would then be to have the government become the only R&D and pharma company.

Doable. But I think you put too much faith in the government. The government is a natural monopoly itself. If they're doing a shitty job you don't get any other options.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by toomuchtodo on Sunday September 20, 2015 @05:53PM (#10249312)
> Doable. But I think you put too much faith in the government. The government is a natural monopoly itself. If they're doing a shitty job you don't get any other options.

Disagree. A government can be held accountable. Some asshole ex-hedge fund manager attempting to corner the market on a drug can't be.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by randyrand on Sunday September 20, 2015 @06:46PM (#10249496)
> A government can be held accountable.

Accountability is not really the main measure we care about (though it's related to it). It's efficiency. We only really care about accountability because its supposed to increase efficiency. People are supposed to get punished when things are running poorly.

The problem is, no one really gets punished when large government organizations are running inefficiently. The business does not go out of business. There is no competition. There is no real incentive to innovate and beat your competitors.

I think we need to reevaluate pharma law. But I don't think replacing the current monopoly with a government one will do much good of anything.

I've long held the belief that whenever there is a supposed failing of private enterprise- it's almost always actually a failing of government. I've yet to be proved wrong. Government makes the barriers of entry too high in the drug market. It's way too easy to have a monopoly because the government basically grants you one.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by toomuchtodo on Sunday September 20, 2015 @07:44PM (#10249661)
I am willing to trade some efficiency/cost effectiveness for price and availability stability.
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by randyrand on Thursday September 24, 2015 @06:50PM (#10275327)
In the longer term you'll get the worst of all worlds. Why not get the best of the short term and long term?

Fix pharma competition.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @04:52PM (#10249062)
Why not skip step 1, then? Let the company sell it for however much it wants, and the non profit competes them out of business?
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by toomuchtodo on Sunday September 20, 2015 @04:55PM (#10249080)
Supply chain stability. Availability is sometimes more important than cost, and if you have a government non-profit producing the drug, you're not wasting any money on the profit that a private company is extracting.

Drugs should be priced based on their cost to produce and whatever R&D needs to be amortized, not by how much value you can extract.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @06:39PM (#10249468)
I still don't understand. Why do you need to set prices for private companies if you're competing with them yourself?
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by toomuchtodo on Sunday September 20, 2015 @06:44PM (#10249494)
Because the free market doesn't work when there's inelastic demand, or when supply chain disruptions cost people their life.
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @07:58PM (#10249700)
If you think the government making the drug is a viable solution, there's no need to set prices. If you think the government making the drug is not a viable solution, then you shouldn't set prices for fear of the drug being cancelled.

Could you point out the flaw here?

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by jgoewert on Monday September 21, 2015 @08:59AM (#10251874)
The government (FDA in this case) doesn't make the medication. They just get someone else to make it. They tell company X "You F'ed Up. Give us all your documentation and we will take it to company Y to make."

I'm trying to remember the name of the company that this happened to. It was like 8 years ago and I think I remember them being a cardiac arrest medical. Anyhow, the company CEO flat out refused the FDA regulators demands that they get their manufacturing process up to standards. The FDA went to another manufacturer (I believe Johnson and Johnson) and asked if they would make the medication and they accepted. The FDA then shut down the prior company.

When lives are impacted, the FDA doesn't mess around. They put CEOs in prison for the crappy decisions they make.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Monday September 21, 2015 @09:23AM (#10252041)
There's a big difference between

"not having a manufacturing process up to standards" and "raising the price insurance companies have to pay".

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by gdrulia on Sunday September 20, 2015 @04:57PM (#10249089)
First I will say that I'm not an expert in these questions, so my thoughts might be off, but that's probably the reason we are discussing it.

The closest to perfect solution in my mind would include all the details to make the medicine in the patent itself (I'm not sure how detailed patents has to be today). This would make it easy for other companies to create a competition once the patent expires and essentially would create a free market.

In the scenarios when it happens that there is only a single player in the market for one or another reason, things get a little trickier. I guess one of the solutions could be a commitment by government to buy/prescribe certain amount of medicine. The price of a unit should be predetermined in such cases to avoid exploitation.

Overall the actual knowledge of how to make a medicine and having a market for it, should make such situation pretty rare when only a single player is left in the market.

Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by ikeboy on Sunday September 20, 2015 @06:38PM (#10249463)
Should all trade secrets be outlawed, then? Or only in medicine?
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by gdrulia on Sunday September 20, 2015 @08:58PM (#10249841)
I believe that if you want the protection of patent, you should disclose everything and it not suppose to be a secret. If you want to keep it as a secret, don't patent it. Isn't that is the reason behind the patent system? Inspire people to create things by providing certainty that no one will be allowed to reproduce their creations until patent expires. The only reasonable thing after that is to make the patented technology (including all the bits and pieces) a public knowledge.
Re:A Huge Overnight Increase in a Drug’s Price Raises Protests by alkonaut on Sunday September 20, 2015 @06:12PM (#10249373)
You seem to believe that one could assign a value to a drug, and that rational actors in a market would choose to buy that drug at a cost at or under this value.