CrHn3
https://cardiacos.net/wp-content/uploads/2019/04/2015-Statin...
Evivo with 2'FL from Layer Origins, a synbiotic prebiotic for this strain. My code is EVIVO-1075 if you want 15% off. It's been successfully engrafted in adults [2] and improving acetate, lactate, and butyrate (byproducts of breaking down the HMO) seems to be correlated with better diabetes outcomes, less inflammation and potential appetite modulation [3]. Bifidobacteria have potential to be protective against T2D [4].
Akkermansia muciniphila with a Layer Origins Super Reds [5, 6]. It's a chicken and egg problem, but reduced Akkermansia muciniphila is associated with obesity and supplementation seems to improve metabolic disorder, but research is limited.
Omega-3 and more poly and mono unsaturated fats [7]. Omega-3 reduced all-cause and cause-specific mortality in diabetes patients [8]. I was vegetarian for a long time and avoided saturated fat, then started eating more when I got into Weston A. Price and started keto and continued to eat moderate fat when not doing a low carb diet. Long term, I've had issues with satiety and discipline even with keto, while a diet with grains helps me feel fuller longer. My sibling did 23 and me and found out they have variation on alleles associated with higher weight with increased saturated fat consumption, which has made me reconsider what kinds of fats I consume [9].
Inositol and COQ10 [10]. Peter Langsjoen, who pioneered the research on ubiquinol, has said he has the healthiest cardiology patients and attributed it to ubiquinol. You need a dose high enough to maintain a certain blood serum level and ubiquinol is water soluble where cheaper ubiquinone is less readily absorbed.
Gluten can be inflammatory for people, and I found this talk helpful for understanding more about leaky gut and dysfunction: https://www.youtube.com/watch?v=evQAzGaW1JU. Emulsifiers have been shown to alter microbiota composition, so less processed foods is probably wise [11]. Dishwasher pods and rinse aids contain alcohol ethoxylates that can disrupt the microbiome but you can find ones that clean decently without them.
1. https://bnrc.springeropen.com/articles/10.1186/s42269-023-01...
2. https://www.cell.com/cell-host-microbe/pdfExtended/S1931-312...
3. https://www.science.org/doi/10.1126/science.aao5774
4. https://www.thelancet.com/journals/ebiom/article/PIIS2352-39...
5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310354/
6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856456/
7. https://www.mdpi.com/2075-1729/13/6/1322
8. https://link.springer.com/article/10.1007/s00592-022-02003-w
9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214897/
10. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5...
11. https://www.sciencedaily.com/releases/2015/02/150225132105.h...
They used EVC001, a robust strain of B. infantis that came out of UC Davis research, and HMOs, which are a symbiotic that it can metabolize into short chain fatty acids, to achieve reversible engraftment without the use of antibiotics. The insurance hypothesis has kind of conflated diversity with function, but it could be possible to have a stable microbiome with less diversity but high function using symbiotics and strains we have identified as contributing to improved function [1].
Wanted to point out that this does not hold true for babies, where Bifidobacterium abundance generally does correlate with healthy microbiota and the strain B. infantis is relevant therapeutically and has evolved to metabolize milk sugars into short chain fatty acids.
Bluesign and Oeko-tex certifications test for BPA. You can find recycled polyester without this (if you have kids, Hanna Andersson's polyester lines claim to be BPA and PFAS free, most Cat and Jack clothing is Oeko-tex certified and Mamavation puts out good information on PFAS in things like children's clothing, backpacks, lunch kits [3]).
1. https://pubmed.ncbi.nlm.nih.gov/33313651/
2. https://www.forbes.com/sites/ariannajohnson/2023/05/18/worri...
Paradoxical responses to drugs are more likely in those with autism [1], which has been noted with benzos [2, 3].
1. https://www.spectrumnews.org/opinion/clinicians-must-put-mor...
2. https://pubmed.ncbi.nlm.nih.gov/2826308/
3. https://www.cambridge.org/core/services/aop-cambridge-core/c...
I take that probiotic, sold as Evivo in the US, and Layer Origin 2’FL HMO and use it with my children.
1. https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(2...
Probiotics can be applied to mitigate undesirable bacterial growth after sanitizing [1].
We can close the gaps by subsidizing Evivo's EVC001 b. infantis and making it a standard that every formula contains 2'FL. Individuals can choose these formulas and purchase b. infantis already. If we were to make it so that all babies, not just NICU babies at hospitals aware of the research, get these two things, public health outcomes (especially those related to autoimmune conditions) should be better than if we continue allowing formula that is not as analogous with breastmilk. We can have better lactation support that is current and evidence based (such as that from ABM contributor Katrina Mitchell https://physicianguidetobreastfeeding.org).
Another reason mom blogs are toxic is because people read past others points when issues are really emotionally charged for them. Really sorry your wife struggled. Formula is fine, but there are reasons breastmilk is pushed, especially since milk is supply and demand and it's hard to identify those with true low supply and those whose bodies just haven't ramped up production yet. Hopefully as a model of immune system response and the impact of b. infantis and HMOs gains more awareness, there will be less pressure since we are assured babies are getting many of the same benefits.
That's your assumption.
You're missing the point, which is that you can supplement formula with both 2'FL and b. infantis and get immune system outcomes that are more similar to those that occur while breastfeeding [1]. The fact that milk typically faciliates a cascade of changes that lay the foundation for a healthy immune system is not at odds with formula feeding. Formula is adequate macronutrition, but if we cannot be honest about the ways in which it is not on par with breastmilk, we will never close the gaps.
1. https://www.nutraingredients.com/Article/2023/05/18/Abbott-s...
B. infantis and human milk oligosaccharides create a feedback loop that encourages the formation of a robust immune system during a critical period [1]. Some formulas contain b. infantis, and some contain 2'FL, the HMO present in breastmilk. The most robust strain is EVC001, which has been shown to be present at a year after 21 days of supplementation. In an observational study, it reduced the diagnosis of necrotizing enterocolitis in very low birth rate infants by 73% [2].
I wish this was common knowledge, but most formulas do not contain these (often they contain other pre and probiotics) and babies are missing out on the specific sugars and bacteria that we know impact the development of the immune system.
1. https://www.cell.com/cell/fulltext/S0092-8674(21)00660-7 2. https://pubmed.ncbi.nlm.nih.gov/35032555/
Vitamin E as α-tocopherol has been associated with increased prostate cancer[3]. Natural tocopherols rich in γ-T, γ-TmT, or similar tocopherol mixtures show more promise for cancer applications[4].
1. https://www.cancer.gov/about-cancer/treatment/cam/hp/coenzym...
2. https://youtu.be/9Z7X9WPWv4Y?si=avOV0u4ruy_zNslr&t=746
While coenzyme Q10 may show indirect anticancer activity through its effect(s) on the immune system, there is evidence to suggest that analogs of this compound can suppress cancer growth directly[1].
1. https://www.cancer.gov/about-cancer/treatment/cam/hp/coenzym...
We do not use timers or set limits around how much time a day. My preschooler enjoys games, learns a lot through TV, has an exceptional vocabulary and a big imagination. They still enjoy spending time outside and playing with others. My hope is that they learn to self regulate early.
They have a chemical policy[1] that is moving in the right direction, and labels like Oeko-Tex 100, Oeko-Tex Made in Green, Clean Beauty, BPA Free, Paraben Free and Recycled. The changes they are making as a part of their chemical policy (eliminating PFAS and other concerning chemicals from cleaning and baby items) are benefiting everyone, and consumers who have specific concerns can quickly get more information about what they are buying. Most consumers are increasingly aware of risks, but most do not have the desire or time to look into the manufacturing process for everything they buy.
1. https://corporate.target.com/sustainability-ESG/environment/...
Some studies have found no differences in alpha diversity[1] when looking at outcomes like longevity. Maybe alpha diversity is the byproduct of healthy flora but it could be possible to engineer a microbiome that was more advantageous for a given population that was less diverse.
Their microbiome is more diverse, with "23.4% of microbial species detected in the Hadza infants represent[ing] novel species"[2].
There seem to be windows where bacterial populations are in flux until the microbiome stabilizes around 3 years of age. It is difficult to modify the microbiome after that. I think our models have to shift so that we prioritize early intervention, especially for those at risk for dysbiosis (like premature and c-section babies).
If you're having a baby, the best thing you can do is to supplement b. infantis, especially the robust strain from Evolve Biosystems[3]. The Hadza have more b. infantis[4] which kicks off a set of immune host interactions that have positive effects on inflammation during the critical period after birth[5].
"After around 3 years, the gut microbiota stabilises retaining relative proportions of taxa with adaptations to composition harder to impose,"[6] so I doubt it's diet as much as it is vertical transmission of the right kinds of bacteria that set the infants up for a lifetime of healthy immune response.
1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103657/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177445/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352178/
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894631/
5. https://www.sciencedirect.com/science/article/pii/S009286742...
The study says, "Psychosocial stress may affect the composition of breast milk via several pathways."
If I'm reading it correctly, a single sample was taken from 146 women. Breastmilk composition tends to be higher in fats and carbohydrates in the first few weeks of life and varies by time of day[1]. It's highly variable (even within a single feeding) in composition, depending on many factors, like if an infant is sick and their age.
Breastfeeding duration seemed like it may be negatively associated with cortisol in school age children in one study[2]. If that's the case, the best thing a mother in a stressful environment can do is breastfeed.
1. https://pubmed.ncbi.nlm.nih.gov/33017792/ 2. https://www.researchgate.net/publication/355137223_Breastfee...
Diarrhea is a concern at 45g for children and 100g for adults. If you introduce it gradually into your diet, it should not be a problem.
My sister has impeccable dental hygiene and many cavities. Her children have had anesthesia because they needed so much dental work. I’m the kind of person who would floss once a year and never had a cavity until I was 28 and drinking many acidic diet sodas. I started the book’s regimen using xylitol, eating basic foods like chocolate and cheese after acidic foods and drinks, took Florassist dental probiotic and stayed on top of cleanings and have had less problems since. My child is okay so far despite some not so great habits. I get extra cleanings that first year and make sure other caregivers do too.
To ensure I get an effective amount of xylitol, I use crystals in my tea and coffee. My child eats them with a spoon. Health Garden is one of the brands that uses birch xylitol.
The NIPT can screen for the sex of the baby earlier than it can be detected on a scan, so many women elect to have it done.
The first trimester ultrasound is around 96% accurate at detection of down’s syndrome.
Contact napping and baby wearing can be helpful to keep your baby happy and sleeping well. Skin to skin contact has benefits for months. I do not do well on little sleep. For the first, I avoided cosleeping until around 4 months because I was worried about SIDS. Co-sleeping following the University of Notre Dame's Mother Baby Sleep Lab recommendations helped me stay rested through night feedings and sleep regressions [1].
Probiotics can help mitigate colic, which is associated with sleep problems, which are a risk factor for developmental and behavioral problems later on [2]. b. infantis is missing in the microbiome of 90% of infants [3]. It's needed to digest the oligosaccharides in breast milk. Feeding b, infantis EVC001 to breastfed infants has been shown to reduce markers of chronic intestinal inflammation by 98% during the first two months of life. The microbiomes of babies are colonized with bifidobacteria in the first days and weeks after birth [4]. Evivo is a company that sells this strain. L reuteri has been shown to help with colic [5].
Taking advice from those emphasizing parenting where both parents share equally in all duties led me to feel like I was doing something wrong as the person who did most feeding and night waking. This works better for us. EEG monitoring has shown that women respond differently than men to infants crying. My husband does not wake in response to the baby crying and has trouble staying up when woken. Do what works for your family.
There is value in all caregivers being able to soothe and feed a baby. It's important to understand what your partner is doing because you both will probably feel like you're doing 60% of the parenting. Relationships can be challenging with a new baby. John Gottman's Bringing Baby Home was a helpful resource for me.
2. https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887...
3. https://www.nature.com/articles/s41598-020-80583-9
We avoid plastic in our kitchen (especially heating it in the dishwasher and microwave) but plastic is difficult to get away from when pumping breast milk. All pumps on the market, aside from silicone hand pumps, have plastic parts that require sanitization after every use.
1. https://www.nature.com/articles/s43016-020-00171-y#article-i...
Different oils have different smoke points, and heating an oil beyond that smoke point can polymerize the oil and produce free radicals.
Charring foods can create heterocyclic amines, which are associated with cancers.