Re:Cofactor Genomics (YC S15) Pursues RNA Testing, Offers Be...
by i000 on Sunday August 02, 2015 @10:18PM
(#9993363)
I am aware of this study. Funny, how they show expression in deltaCT to make it appear higher in cancer ;). But regardless, the marker has a specificity of 0.62 - really that excellent? Such a high false-positive rate does not belong anywhere near a patient sample.
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Re:Cofactor Genomics (YC S15) Pursues RNA Testing, Offers Be...
by jarmstropreamp on Sunday August 02, 2015 @11:01PM
(#9993500)
Our goal is to add additional markers to current candidates using our enrichment tech. It helps to remember that up until the ILMN/Solexa machine came online around 2005-6, we could not reliably detect (statistically) MAFs in heterogenous tumor samples below about 20% on the 454 platform (depending on how much cash you threw at the sample). Point is, our enrichment platform allows a deep dive into signals that have yet to be identified as reliable and low variance biomarkers.