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That is not true. For many diseases we lack good hypotheses about the underlying causal mechanisms which resulted in decades and billions being pumped into few questionable targets (e.g. amyloid and alzheimers). In other diseases such as many cancers we often lack "actionable" targets, resulting in hundreds me-too companies all chasing the same target with only subtle variations in approach (inefficient capital alocation).

So AI could help a lot in discovery, much more than the engineering like uses in antibody/drug optimization.

Economic mismanagement assumes there is economic management, and this is a very recent development. I would wager that we still do not know how to manage economies well in the long run - case in point US deficit and wealth inequality.

Such a good comment, I would also add how much our perception of technology lifting conditions is conflated with the increased ability of governments to steer the economy to smooth things over.

What is a "simple-ish open problem". I guess it falls under "solving this open problem in mathemathics is left as an exercise to the reader" ;)

It would not even help me with updating my CV because I work in biology...

They want to encourage diversifying model use.

I guess that is at the core of Google vs Oracle, they copied the API kept the implementation clean-room. It was definitvely ruled that this was fair use. If fair use applies to something as strict as re-implementing an API, I would argue it applies to something much more elusive, like cloning UI/layout.

That is my point people are pro-AI / anti-AI and pro-automation / anti-automation, there is nothing weird about it.

Weirdly common I would say. US dockworkers / longshoremen are anti-automation big time.

https://ilaunion.org/the-ilas-fight-against-automation-prese...

The lack of productivity-growth in construction is also telling that this industry as a whole may be a bit too pro-hammer and anti-innovation

https://www.goldmansachs.com/insights/articles/why-has-produ...

This happened to me in elementary school. We were doing fingerpaintings using plasticine. After all the bikes were hung on the wall, mine was racing the other way... Somehow it really stuck with me.

Indeed hilarious considering my grandparent still remember being put into a german nazi concentration camp.

Hmm.The point was that people with Alzheimers have trouble interpreting images, and obviously remain concious until the latest stages of their disease.

> do have long-term memory from their training and thus act very much like someone suffering from Alzheimer’s.

Your 8th grade science teacher may be disappointed too. Drawing such analogies using unequivocal language "very much like" disregards the limited understanding of LLMs, the false analogies between computer and biological systems, and the complex nature of Alzheimer's disease (no it is not just short term memory loss, not even close, for example ability to interpret images)

Have you looked at the rise of Germany's right-wing politics recently? AfD with 18.8% in Baden-Württemberg (west Germany, relatively rich).

Gearmany's pacifism is just like its green energy transition hypocrytical and ineffective. Their Energiewende was to shutdown nuclear to bring back coal. Their Zeitenwend amounted to bankrolling Putin's war machine via the Norstream pipelines at the expense of the very same countries they tried to anhiliate in WW2. So yeah, I think I can crack a joke.

Not sure why you are voted down. Came here to make the same joke.

It is also wrong...

What makes ggplot great is that it allows manual adjustments AND has a nice declerative grammar. Hard for me to see the value of a plotting library without being able to adjust plots.

Imagine a pizza place that allows you to pick from 40+ toppings but you can only order a margherita ;) /s

Agreed. What you wrote was probably the input, what we see is the LLM output with the directive to "make us sound smart, put gratuitous em-dash"

Would it make sense to embed such single-purpose network with fixed weights within a LLM before pre-training?

Me neither, but what you present is a false dichotomy. Science used to be a past time of the wealthy elites, it became a profession. By opening up it up progrss was accelerated. Same will happen when publication will be made more open and accessible.

Perhaps the real issue is the gate-keeping scientific publishing model. Journals had a place and role, and peer-review is a critical aspect of the scientific process but new times (internet, citizien science, higher levels of scientific literacy, and now AI) diminish the benefits of journals creating "barriers to entry" as you put it.

What makes you think that this 'surplus' GDP will be captured by those who do the investments?

What an utterly disappointing comment. FWIW I spent 15min on the app, and found it very helpful to see examples of the various kinds of skin lesion - it will likely motivate me to see a doctor when I see a similar malignant skin lesion. Educating people is very helpful.

If you take advantage of all the featuers in Teams, perhaps. But we needed a tiny bit from Workbench, a little bit from Connect, and sliver from Package Manager - and Teans ended up eating a huge portion of our IT bill, effectively stunting our efficiency as a research organization. Over the years, while our use case did not change, our Posit bill more than doubled.

Thank you for the response! My key recommendation is to unbundle. At one point we have been told "It got 35% more expensive, but it does so much more now it supports Python" - we didn't ask for Python. To effectively use Connect with private packages you need this other full-blown institutional Package Manager license, 99% of your users will not need. Also per-named-user pricing (rather than per active seat) is so aggressive. A user uses a shiny app once in a year, still need a full per year license.... I feel Posit is one of the most agressive companies in terms of upselling, while positioning as this benevolent PBC / Open-Source institution - just go full Oracle at least we will know where things stand.

I am talking about the RStudio Server and Connect - these are really expensive. One of the sales reps claimed that it is so expensive because they are a PBC and support open-source development. As in if they were just for profit it would be cheaper, but we should feel good about paying more. I could not take it.

What is the alternative? Posit princing is absurd. Even academia is charged arm and leg - and the value, very questionable.

I think this is pretty much how many Amish communities function. As for me, I prefer making decisions on how to use technology in my own life on my own.