The people who deal with it best I think are sort of the aloof types. They may not even read their own Twitter feed, delegating it to a social-media staffer. Notch has the problem that he uses it as a personal account and is on it regularly, so he reads comments @directed at him, tries to reply to them, etc. He also has a public email address that he reads, and it sounds like people send weird/angry emails to that, too, so it ends up going beyond just Twitter. I could see getting annoyed if people were constantly emailing me in that manner.