I'm not sure what combination of this list of things does the most good, but I rarely get eyestrain and I look at screens for 12+ hours per day.
Not sure if this matters, but I had LASIK surgery 7 years ago and ever since my eyes have been pretty sensitive to light (night vision FTW), so this is something I've been working on for a while now.
Edit: I am 40 years old, and have been looking at screens for long hours at least 10-15 years now.
Manufacturers likely set this so that the colours 'pop' when being demoed (the same reason they sell/create/display glossy monitors, because they demo well).
Taking the brightness down almost never impacts usability, but I've found can significantly affect eye strain (that 'OMG, my eyeballs are hurting' feeling).
They create very few of them. The few they do create are because some of us want monitors that are not intentionally blurry. I am capable of controlling the lighting in my environment. I do not want my monitor to deliberately make everything fuzzy just to avoid a glare problem I don't have.
When I work remote using my laptop I always end with a headache and often tired eyes as well.
Many many hackers at my office use 3 column tmux or screen terminal sessions all day long on 11 in laptop screens, but monitors are cheap so why strain your eyes?
As others have mentioned check on ambient lighting and brightness settings. You may also want to try setting your white balance, contrast and saturation levels. Factory defaults are for making them look good in on display in a store, not for daily use.
I asked my optometrist about this. He said that our extraocular muscles get tired like any other muscle on the body, and it's normal to feel that way after staring at a screen for extended periods.
FWIW I have good vision and don't wear glasses.
Here's my setup if you are curious:
There are software tools like Flux and Redshift for the PC, Screen Filter for Android (which I just use to turn off the LED lights) -- all intended to reduce the light (typically the 'harsher' blues) to absorb. Some people use orange safety glasses to accomplish the same goal: http://www.amazon.com/dp/B000USRG90
Also, check this out: https://www.lowbluelights.com/index.asp?
"blue lights block melatonin creation". They sell lights designed to keep the room lit but not interrupt with your melatonin production thus allowing you to turn off the computer & reach sleep.
As a tip, definitely enforce the break. You are always tempted to get out of it if you don't.
I took on the habit of looking a distant wall every half hour or so for a couple minute or go drink a coffee, but while it helps with the "always looking close" vision I still have a very tired feel in my eyes at the end of a long day.
I do have good vision and have it checked every year, but I worry I'm doing some long term damage anyway, and the white of my eyes does look more bloodshot than they do in average people my ages (and gets a lot worse after big long hours release/bugfix days).
Do you guys have any tips to help the eyes rest ?