Humans have the same protein. Knock out studies in mice have historically been very informative about human biology (with some exceptions). That’s very different from drug studies, where the molecules not only have to have the same effect in the model species, but also all off target effects have to be similar. That’s a higher barrier to clear and why mice studies of pharmaceutical interventions should (and do) face higher scrutiny.

interesting, i exactly read the opposite position from biologists that the mice experiments are now very useful when it comes to applicability to humans. I guess we have every possible oppinion.

The reasoning they gave seems plausible, what reasoning do your biologists give for holding the opposite position?

I don't think that any self-respecting biologist would actually make any sort of categorical dismissal of research in mice. That kind of research has been the basis of noble prize-winning advancements in immunotherapies that now positively impact cancer survival rates for humans.

I'm sure the totality of opinions from biologists is vast and complex, but there is no way that "all opinions have been expressed" is a faithful report of the state of our knowledge on biology.

The "in mice" meme needs to be retired. We share critical similarities in DNA, proteins, immune systems and immune responses that already have been the basis for impressive advances in research applicable to humans when it comes to immunotherapies.

We shouldn't overhype research done on mice but we also shouldn't reflexively dismiss it as unrelated to humans.

There is a natural tendency to hype basic research as having human applications because perhaps that will attract funding. But most of us are reading science news without any practical use for it. It's useful to have a succinct reminder to avoid getting too excited about it.

I think more people mean it and understand it in a literal sense than you seem to appreciate.

And yet the only human data they found to substantiate their claim is that little Figure 7.

Which is why I stressed the human relevant merits of "in mice" research in the part of my comment you're not responding to.